Correlation of pre-operative CT findings with surgical & histological tumor dissemination patterns at cytoreduction for primary advanced and relapsed epithelial ovarian cancer
Objectives Computed tomography (CT) is an essential part of preoperative planning prior to cytoreductive surgery for primary and relapsed epithelial ovarian cancer (EOC). Our aim is to correlate pre-operative CT results with intraoperative surgical and histopathological findings at debulking surgery...
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2016
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| Online Access: | http://hdl.handle.net/10725/5153 http://dx.doi.org/10.1016/j.ygyno.2016.08.322 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.sciencedirect.com/science/article/pii/S0090825816313488 |
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| _version_ | 1864513465318637568 |
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| author | Nasser, S. |
| author2 | Lazaridis, A. Evangelou, M. Jones, B. Nixon, K. Kyrgiou, M. Gabra, H. Rockall, A. Fotopoulou, C. |
| author2_role | author author author author author author author author |
| author_facet | Nasser, S. Lazaridis, A. Evangelou, M. Jones, B. Nixon, K. Kyrgiou, M. Gabra, H. Rockall, A. Fotopoulou, C. |
| author_role | author |
| dc.creator.none.fl_str_mv | Nasser, S. Lazaridis, A. Evangelou, M. Jones, B. Nixon, K. Kyrgiou, M. Gabra, H. Rockall, A. Fotopoulou, C. |
| dc.date.none.fl_str_mv | 2016 2017-02-02T09:17:21Z 2017-02-02T09:17:21Z 2017-02-02 |
| dc.identifier.none.fl_str_mv | 0090-8258 http://hdl.handle.net/10725/5153 http://dx.doi.org/10.1016/j.ygyno.2016.08.322 Nasser, S., Lazaridis, A., Evangelou, M., Jones, B., Nixon, K., Kyrgiou, M., ... & Fotopoulou, C. (2016). Correlation of pre-operative CT findings with surgical & histological tumor dissemination patterns at cytoreduction for primary advanced and relapsed epithelial ovarian cancer: A retrospective evaluation. Gynecologic Oncology, 143(2), 264-269. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.sciencedirect.com/science/article/pii/S0090825816313488 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Gynecologic Oncology |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Correlation of pre-operative CT findings with surgical & histological tumor dissemination patterns at cytoreduction for primary advanced and relapsed epithelial ovarian cancer a retrospective evaluation |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Objectives Computed tomography (CT) is an essential part of preoperative planning prior to cytoreductive surgery for primary and relapsed epithelial ovarian cancer (EOC). Our aim is to correlate pre-operative CT results with intraoperative surgical and histopathological findings at debulking surgery. Methods We performed a systematic comparison of intraoperative tumor dissemination patterns and surgical resections with preoperative CT assessments of infiltrative disease at key resection sites, in women who underwent multivisceral debulking surgery due to EOC between January 2013 and December 2014 at a tertiary referral center. The key sites were defined as follows: diaphragmatic involvement(DI), splenic disease (SI), large (LBI) and small (SBI) bowel involvement, rectal involvement (RI), porta hepatis involvement (PHI), mesenteric disease (MI) and lymph node involvement (LNI). Results A total of 155 patients, mostly with FIGO stage IIIC disease (65%) were evaluated (primary = 105, relapsed = 50). Total macroscopic cytoreduction rates were: 89%. Pre-operative CT findings displayed high specificity across all tumor sites apart from the retroperitoneal lymph node status, with a specificity of 65%. The ability however of the CT to accurately identify sites affected by invasive disease was relatively low with the following sensitivities as relating to final histology: 32% (DI), 26% (SI), 46% (LBI), 44% (SBI), 39% (RI), 57% (PHI), 31% (MI), 63% (LNI). Conclusion Pre-operative CT imaging shows high specificity but low sensitivity in detecting tumor involvement at key sites in ovarian cancer surgery. CT findings alone should not be used for surgical decision making. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_ec19fcc45a3163d9b42bf46d3e7cce52 |
| identifier_str_mv | 0090-8258 Nasser, S., Lazaridis, A., Evangelou, M., Jones, B., Nixon, K., Kyrgiou, M., ... & Fotopoulou, C. (2016). Correlation of pre-operative CT findings with surgical & histological tumor dissemination patterns at cytoreduction for primary advanced and relapsed epithelial ovarian cancer: A retrospective evaluation. Gynecologic Oncology, 143(2), 264-269. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/5153 |
| publishDate | 2016 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Correlation of pre-operative CT findings with surgical & histological tumor dissemination patterns at cytoreduction for primary advanced and relapsed epithelial ovarian cancera retrospective evaluationNasser, S.Lazaridis, A.Evangelou, M.Jones, B.Nixon, K.Kyrgiou, M.Gabra, H.Rockall, A.Fotopoulou, C.Objectives Computed tomography (CT) is an essential part of preoperative planning prior to cytoreductive surgery for primary and relapsed epithelial ovarian cancer (EOC). Our aim is to correlate pre-operative CT results with intraoperative surgical and histopathological findings at debulking surgery. Methods We performed a systematic comparison of intraoperative tumor dissemination patterns and surgical resections with preoperative CT assessments of infiltrative disease at key resection sites, in women who underwent multivisceral debulking surgery due to EOC between January 2013 and December 2014 at a tertiary referral center. The key sites were defined as follows: diaphragmatic involvement(DI), splenic disease (SI), large (LBI) and small (SBI) bowel involvement, rectal involvement (RI), porta hepatis involvement (PHI), mesenteric disease (MI) and lymph node involvement (LNI). Results A total of 155 patients, mostly with FIGO stage IIIC disease (65%) were evaluated (primary = 105, relapsed = 50). Total macroscopic cytoreduction rates were: 89%. Pre-operative CT findings displayed high specificity across all tumor sites apart from the retroperitoneal lymph node status, with a specificity of 65%. The ability however of the CT to accurately identify sites affected by invasive disease was relatively low with the following sensitivities as relating to final histology: 32% (DI), 26% (SI), 46% (LBI), 44% (SBI), 39% (RI), 57% (PHI), 31% (MI), 63% (LNI). Conclusion Pre-operative CT imaging shows high specificity but low sensitivity in detecting tumor involvement at key sites in ovarian cancer surgery. CT findings alone should not be used for surgical decision making.PublishedN/A2017-02-02T09:17:21Z2017-02-02T09:17:21Z20162017-02-02Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article0090-8258http://hdl.handle.net/10725/5153http://dx.doi.org/10.1016/j.ygyno.2016.08.322Nasser, S., Lazaridis, A., Evangelou, M., Jones, B., Nixon, K., Kyrgiou, M., ... & Fotopoulou, C. (2016). Correlation of pre-operative CT findings with surgical & histological tumor dissemination patterns at cytoreduction for primary advanced and relapsed epithelial ovarian cancer: A retrospective evaluation. Gynecologic Oncology, 143(2), 264-269.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttp://www.sciencedirect.com/science/article/pii/S0090825816313488enGynecologic Oncologyinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/51532021-03-19T10:00:53Z |
| spellingShingle | Correlation of pre-operative CT findings with surgical & histological tumor dissemination patterns at cytoreduction for primary advanced and relapsed epithelial ovarian cancer Nasser, S. |
| status_str | publishedVersion |
| title | Correlation of pre-operative CT findings with surgical & histological tumor dissemination patterns at cytoreduction for primary advanced and relapsed epithelial ovarian cancer |
| title_full | Correlation of pre-operative CT findings with surgical & histological tumor dissemination patterns at cytoreduction for primary advanced and relapsed epithelial ovarian cancer |
| title_fullStr | Correlation of pre-operative CT findings with surgical & histological tumor dissemination patterns at cytoreduction for primary advanced and relapsed epithelial ovarian cancer |
| title_full_unstemmed | Correlation of pre-operative CT findings with surgical & histological tumor dissemination patterns at cytoreduction for primary advanced and relapsed epithelial ovarian cancer |
| title_short | Correlation of pre-operative CT findings with surgical & histological tumor dissemination patterns at cytoreduction for primary advanced and relapsed epithelial ovarian cancer |
| title_sort | Correlation of pre-operative CT findings with surgical & histological tumor dissemination patterns at cytoreduction for primary advanced and relapsed epithelial ovarian cancer |
| url | http://hdl.handle.net/10725/5153 http://dx.doi.org/10.1016/j.ygyno.2016.08.322 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.sciencedirect.com/science/article/pii/S0090825816313488 |