Osteosarcomatosis with rothmund-thomson syndrome
We describe the second reported case of multicentric osteosarcoma associated with Rothmund-Thomson syndrome (RTS), a rare hereditary cancer-prone genodermatosis characterized by typical cutaneous lesions and other non-dermatological pathological manifestations, particularly skeletal changes. A high...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , |
| التنسيق: | article |
| منشور في: |
1977
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/10478 https://doi.org/10.1259/bjr.70.830.9135453 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.birpublications.org/doi/abs/10.1259/bjr.70.830.9135453 |
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| _version_ | 1864513486629896192 |
|---|---|
| author | El-Khoury, J.M. |
| author2 | Haddad, S.N. Atallah, N.G. |
| author2_role | author author |
| author_facet | El-Khoury, J.M. Haddad, S.N. Atallah, N.G. |
| author_role | author |
| dc.creator.none.fl_str_mv | El-Khoury, J.M. Haddad, S.N. Atallah, N.G. |
| dc.date.none.fl_str_mv | 1977 2019-04-17T13:35:46Z 2019-04-17T13:35:46Z 2019-04-17 |
| dc.identifier.none.fl_str_mv | 1748-880X http://hdl.handle.net/10725/10478 https://doi.org/10.1259/bjr.70.830.9135453 El-Khoury, J. M., Haddad, S. N., & Atallah, N. G. (1997). Osteosarcomatosis with Rothmund-Thomson syndrome. The British journal of radiology, 70(830), 215-218. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.birpublications.org/doi/abs/10.1259/bjr.70.830.9135453 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | The British journal of radiology |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Osteosarcomatosis with rothmund-thomson syndrome |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | We describe the second reported case of multicentric osteosarcoma associated with Rothmund-Thomson syndrome (RTS), a rare hereditary cancer-prone genodermatosis characterized by typical cutaneous lesions and other non-dermatological pathological manifestations, particularly skeletal changes. A high incidence of malignant disorders has been found in RTS patients. This could be explained by the diminished capacity of DNA-repair demonstrated in the fibroblasts of RTS patients following exposure to oncogenic stimuli. The severe cutaneous lesions and the benign bone lesions found in RTS may be considered a predisposing factor to the particularly frequent skin carcinoma and osteogenic sarcoma encountered in these cancer-prone patients. A brief review of the literature is given, with a discussion of the association between these two rare conditions. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_ed05017604523dfd72d53bec041e760c |
| identifier_str_mv | 1748-880X El-Khoury, J. M., Haddad, S. N., & Atallah, N. G. (1997). Osteosarcomatosis with Rothmund-Thomson syndrome. The British journal of radiology, 70(830), 215-218. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/10478 |
| publishDate | 1977 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Osteosarcomatosis with rothmund-thomson syndromeEl-Khoury, J.M.Haddad, S.N.Atallah, N.G.We describe the second reported case of multicentric osteosarcoma associated with Rothmund-Thomson syndrome (RTS), a rare hereditary cancer-prone genodermatosis characterized by typical cutaneous lesions and other non-dermatological pathological manifestations, particularly skeletal changes. A high incidence of malignant disorders has been found in RTS patients. This could be explained by the diminished capacity of DNA-repair demonstrated in the fibroblasts of RTS patients following exposure to oncogenic stimuli. The severe cutaneous lesions and the benign bone lesions found in RTS may be considered a predisposing factor to the particularly frequent skin carcinoma and osteogenic sarcoma encountered in these cancer-prone patients. A brief review of the literature is given, with a discussion of the association between these two rare conditions.PublishedN/A2019-04-17T13:35:46Z2019-04-17T13:35:46Z19772019-04-17Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1748-880Xhttp://hdl.handle.net/10725/10478https://doi.org/10.1259/bjr.70.830.9135453El-Khoury, J. M., Haddad, S. N., & Atallah, N. G. (1997). Osteosarcomatosis with Rothmund-Thomson syndrome. The British journal of radiology, 70(830), 215-218.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://www.birpublications.org/doi/abs/10.1259/bjr.70.830.9135453enThe British journal of radiologyinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/104782021-03-19T10:45:33Z |
| spellingShingle | Osteosarcomatosis with rothmund-thomson syndrome El-Khoury, J.M. |
| status_str | publishedVersion |
| title | Osteosarcomatosis with rothmund-thomson syndrome |
| title_full | Osteosarcomatosis with rothmund-thomson syndrome |
| title_fullStr | Osteosarcomatosis with rothmund-thomson syndrome |
| title_full_unstemmed | Osteosarcomatosis with rothmund-thomson syndrome |
| title_short | Osteosarcomatosis with rothmund-thomson syndrome |
| title_sort | Osteosarcomatosis with rothmund-thomson syndrome |
| url | http://hdl.handle.net/10725/10478 https://doi.org/10.1259/bjr.70.830.9135453 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.birpublications.org/doi/abs/10.1259/bjr.70.830.9135453 |