Putting the ‘HAT’ back on survival signalling
Decreased histone acetyltransferase activity and transcriptional dysfunction have been implicated in almost all neurodegenerative conditions. Increasing net histone acetyltransferase activity through inhibition of the histone deacetylases (HDACs) has been shown to be an effective strategy to delay o...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , |
| التنسيق: | article |
| منشور في: |
2009
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/6143 http://dx.doi.org/10.1517/13543780902810345 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.tandfonline.com/doi/abs/10.1517/13543780902810345 |
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| _version_ | 1864513478588366848 |
|---|---|
| author | Sleiman, Sama F. |
| author2 | Basso, Manuela Mashishi, Lata Kozikowski, Alan P. Donohoe, Mary E. Langley, Brett Ratan, Rajiv R. |
| author2_role | author author author author author author |
| author_facet | Sleiman, Sama F. Basso, Manuela Mashishi, Lata Kozikowski, Alan P. Donohoe, Mary E. Langley, Brett Ratan, Rajiv R. |
| author_role | author |
| dc.creator.none.fl_str_mv | Sleiman, Sama F. Basso, Manuela Mashishi, Lata Kozikowski, Alan P. Donohoe, Mary E. Langley, Brett Ratan, Rajiv R. |
| dc.date.none.fl_str_mv | 2009 2017-09-06T09:13:13Z 2017-09-06T09:13:13Z 2017-09-06 |
| dc.identifier.none.fl_str_mv | 1744-7658 http://hdl.handle.net/10725/6143 http://dx.doi.org/10.1517/13543780902810345 Sleiman, S. F., Basso, M., Mahishi, L., Kozikowski, A. P., Donohoe, M. E., Langley, B., & Ratan, R. R. (2009). Putting the ‘HAT’back on survival signalling: the promises and challenges of HDAC inhibition in the treatment of neurological conditions. Expert opinion on investigational drugs, 18(5), 573-584. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.tandfonline.com/doi/abs/10.1517/13543780902810345 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Expert Opinion on Investigational Drugs |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Putting the ‘HAT’ back on survival signalling the promises and challenges of HDAC inhibition in the treatment of neurological conditions |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Decreased histone acetyltransferase activity and transcriptional dysfunction have been implicated in almost all neurodegenerative conditions. Increasing net histone acetyltransferase activity through inhibition of the histone deacetylases (HDACs) has been shown to be an effective strategy to delay or halt progression of neurological disease in cellular and rodent models. These findings have provided firm rationale for Phase I and Phase II clinical trials of HDAC inhibitors in Huntington's disease, spinal muscular atrophy, and Freidreich's ataxia. In this review, we discuss the current findings and promise of HDAC inhibition as a strategy for treating neurological disorders. Despite the fact that HDAC inhibitors are in an advanced stage of development, we suggest other approaches to modulating HDAC function that may be less toxic and more efficacious than the canonical agents developed so far. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_ed2626de78b303d2002e81d4c7637afd |
| identifier_str_mv | 1744-7658 Sleiman, S. F., Basso, M., Mahishi, L., Kozikowski, A. P., Donohoe, M. E., Langley, B., & Ratan, R. R. (2009). Putting the ‘HAT’back on survival signalling: the promises and challenges of HDAC inhibition in the treatment of neurological conditions. Expert opinion on investigational drugs, 18(5), 573-584. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/6143 |
| publishDate | 2009 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Putting the ‘HAT’ back on survival signallingthe promises and challenges of HDAC inhibition in the treatment of neurological conditionsSleiman, Sama F.Basso, ManuelaMashishi, LataKozikowski, Alan P.Donohoe, Mary E.Langley, BrettRatan, Rajiv R.Decreased histone acetyltransferase activity and transcriptional dysfunction have been implicated in almost all neurodegenerative conditions. Increasing net histone acetyltransferase activity through inhibition of the histone deacetylases (HDACs) has been shown to be an effective strategy to delay or halt progression of neurological disease in cellular and rodent models. These findings have provided firm rationale for Phase I and Phase II clinical trials of HDAC inhibitors in Huntington's disease, spinal muscular atrophy, and Freidreich's ataxia. In this review, we discuss the current findings and promise of HDAC inhibition as a strategy for treating neurological disorders. Despite the fact that HDAC inhibitors are in an advanced stage of development, we suggest other approaches to modulating HDAC function that may be less toxic and more efficacious than the canonical agents developed so far.PublishedN/A2017-09-06T09:13:13Z2017-09-06T09:13:13Z20092017-09-06Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1744-7658http://hdl.handle.net/10725/6143http://dx.doi.org/10.1517/13543780902810345Sleiman, S. F., Basso, M., Mahishi, L., Kozikowski, A. P., Donohoe, M. E., Langley, B., & Ratan, R. R. (2009). Putting the ‘HAT’back on survival signalling: the promises and challenges of HDAC inhibition in the treatment of neurological conditions. Expert opinion on investigational drugs, 18(5), 573-584.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttp://www.tandfonline.com/doi/abs/10.1517/13543780902810345enExpert Opinion on Investigational Drugsinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/61432021-03-19T10:00:49Z |
| spellingShingle | Putting the ‘HAT’ back on survival signalling Sleiman, Sama F. |
| status_str | publishedVersion |
| title | Putting the ‘HAT’ back on survival signalling |
| title_full | Putting the ‘HAT’ back on survival signalling |
| title_fullStr | Putting the ‘HAT’ back on survival signalling |
| title_full_unstemmed | Putting the ‘HAT’ back on survival signalling |
| title_short | Putting the ‘HAT’ back on survival signalling |
| title_sort | Putting the ‘HAT’ back on survival signalling |
| url | http://hdl.handle.net/10725/6143 http://dx.doi.org/10.1517/13543780902810345 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.tandfonline.com/doi/abs/10.1517/13543780902810345 |