Phosphodiesterase 4B in the cardiac L-type Ca2+ channel complex regulates Ca2+ current and protects against ventricular arrhythmias in mice

Phosphodiesterase 4B in the cardiac L-type Ca2+ channel complex regulates Ca2+ current and protects against ventricular arrhythmias in mice

β-Adrenergic receptors (β-ARs) enhance cardiac contractility by increasing cAMP levels and activating PKA. PKA increases Ca2+-induced Ca2+ release via phosphorylation of L-type Ca2+ channels (LTCCs) and ryanodine receptor 2. Multiple cyclic nucleotide phosphodiesterases (PDEs) regulate local cAMP co...

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Bibliographic Details
Main Author: Leroy, Jerome (author)
Other Authors: Richter, Wito (author), Mika, Delphine (author), Castro, Liliana.R. V. (author), Abi-Gerges, Aniella (author), Xie, Moses (author), Scheitrum, Colleen (author), Lefebvre, Florence (author), Schittl, Julia (author), Vandecasteele, Grégoire (author)
Format: article
Published: 2011
Online Access:http://hdl.handle.net/10725/6359
http://dx.doi.org/10.1172/JCI44747
http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php
https://www.jci.org/articles/view/44747
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Internet

http://hdl.handle.net/10725/6359
http://dx.doi.org/10.1172/JCI44747
http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php
https://www.jci.org/articles/view/44747

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