Hepatoprotective, Antioxidant, and Anticancer Effects of the Tragopogon porrifolius Methanolic Extract
Tragopogon porrifolius (Asteraceae), commonly referred to as white salsify, is an edible herb used in Lebanese folk medicine to treat cancer and liver dysfunction. In this study, we investigated the antioxidant activity of Tragopogon porrifolius methanolic extract, both in vitro and in vivo, in addi...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , |
| التنسيق: | article |
| منشور في: |
2015
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/2818 http://dx.doi.org/10.1155/2015/161720 http://www.hindawi.com/journals/ecam/2015/161720/abs/ |
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إضافة وسم
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| _version_ | 1864513459426689024 |
|---|---|
| author | Tenkerian, Clara |
| author2 | El-Sibai, Mirvat Daher, Costantine F. Mroueh, Mohamad |
| author2_role | author author author |
| author_facet | Tenkerian, Clara El-Sibai, Mirvat Daher, Costantine F. Mroueh, Mohamad |
| author_role | author |
| dc.creator.none.fl_str_mv | Tenkerian, Clara El-Sibai, Mirvat Daher, Costantine F. Mroueh, Mohamad |
| dc.date.none.fl_str_mv | 2015-12-16T09:23:51Z 2015-12-16T09:23:51Z 2015 2015-12-16 |
| dc.identifier.none.fl_str_mv | 2211-0534 http://hdl.handle.net/10725/2818 http://dx.doi.org/10.1155/2015/161720 Tenkerian, C., El-Sibai, M., Daher, C. F., & Mroueh, M. (2015). Hepatoprotective, Antioxidant, and Anticancer Effects of the Tragopogon porrifolius Methanolic Extract. Evidence-Based Complementary and Alternative Medicine, 2015. http://www.hindawi.com/journals/ecam/2015/161720/abs/ |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Evidence-Based Complementary and Alternative Medicine |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Hepatoprotective, Antioxidant, and Anticancer Effects of the Tragopogon porrifolius Methanolic Extract |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Tragopogon porrifolius (Asteraceae), commonly referred to as white salsify, is an edible herb used in Lebanese folk medicine to treat cancer and liver dysfunction. In this study, we investigated the antioxidant activity of Tragopogon porrifolius methanolic extract, both in vitro and in vivo, in addition to its hepatoprotective and anticancer activities. Total phenolic and flavonoid contents were measured and found to be mg GAE/g and mg QE/g dry weight, respectively. In vitro antioxidant assays revealed an FRAP value of µmol Fe2+/g of extract and DPPH IC50 value 15.2 µg/mL. In rats subjected to CCl4-induced hepatotoxicity, significant increase in CAT, SOD, and GST levels was detected. The highest dose of the extract (250 mg/kg) recorded a fold increase of 1.68 for SOD, 2.49 for GST, and 3.2 for CAT. The extract also showed substantial decrease in AST (57%), ALT (56%), and LDH (65%) levels. Additionally, the extract caused a dose-dependent decrease in cell viability and proliferation. In conclusion, the methanolic extract of T. porrifolius displayed a relatively high antioxidant activity both in vitro and in vivo as well as hepatoprotective potential against liver toxicity in rats and anticancer effect on MDA-MB-231 and Caco-2 cells. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_edbb52ae3dcdb9905207caa12eb981e2 |
| identifier_str_mv | 2211-0534 Tenkerian, C., El-Sibai, M., Daher, C. F., & Mroueh, M. (2015). Hepatoprotective, Antioxidant, and Anticancer Effects of the Tragopogon porrifolius Methanolic Extract. Evidence-Based Complementary and Alternative Medicine, 2015. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/2818 |
| publishDate | 2015 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Hepatoprotective, Antioxidant, and Anticancer Effects of the Tragopogon porrifolius Methanolic ExtractTenkerian, ClaraEl-Sibai, MirvatDaher, Costantine F.Mroueh, MohamadTragopogon porrifolius (Asteraceae), commonly referred to as white salsify, is an edible herb used in Lebanese folk medicine to treat cancer and liver dysfunction. In this study, we investigated the antioxidant activity of Tragopogon porrifolius methanolic extract, both in vitro and in vivo, in addition to its hepatoprotective and anticancer activities. Total phenolic and flavonoid contents were measured and found to be mg GAE/g and mg QE/g dry weight, respectively. In vitro antioxidant assays revealed an FRAP value of µmol Fe2+/g of extract and DPPH IC50 value 15.2 µg/mL. In rats subjected to CCl4-induced hepatotoxicity, significant increase in CAT, SOD, and GST levels was detected. The highest dose of the extract (250 mg/kg) recorded a fold increase of 1.68 for SOD, 2.49 for GST, and 3.2 for CAT. The extract also showed substantial decrease in AST (57%), ALT (56%), and LDH (65%) levels. Additionally, the extract caused a dose-dependent decrease in cell viability and proliferation. In conclusion, the methanolic extract of T. porrifolius displayed a relatively high antioxidant activity both in vitro and in vivo as well as hepatoprotective potential against liver toxicity in rats and anticancer effect on MDA-MB-231 and Caco-2 cells.PublishedN/A2015-12-16T09:23:51Z2015-12-16T09:23:51Z20152015-12-16Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2211-0534http://hdl.handle.net/10725/2818http://dx.doi.org/10.1155/2015/161720Tenkerian, C., El-Sibai, M., Daher, C. F., & Mroueh, M. (2015). Hepatoprotective, Antioxidant, and Anticancer Effects of the Tragopogon porrifolius Methanolic Extract. Evidence-Based Complementary and Alternative Medicine, 2015.http://www.hindawi.com/journals/ecam/2015/161720/abs/enEvidence-Based Complementary and Alternative Medicineinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/28182024-01-31T15:19:09Z |
| spellingShingle | Hepatoprotective, Antioxidant, and Anticancer Effects of the Tragopogon porrifolius Methanolic Extract Tenkerian, Clara |
| status_str | publishedVersion |
| title | Hepatoprotective, Antioxidant, and Anticancer Effects of the Tragopogon porrifolius Methanolic Extract |
| title_full | Hepatoprotective, Antioxidant, and Anticancer Effects of the Tragopogon porrifolius Methanolic Extract |
| title_fullStr | Hepatoprotective, Antioxidant, and Anticancer Effects of the Tragopogon porrifolius Methanolic Extract |
| title_full_unstemmed | Hepatoprotective, Antioxidant, and Anticancer Effects of the Tragopogon porrifolius Methanolic Extract |
| title_short | Hepatoprotective, Antioxidant, and Anticancer Effects of the Tragopogon porrifolius Methanolic Extract |
| title_sort | Hepatoprotective, Antioxidant, and Anticancer Effects of the Tragopogon porrifolius Methanolic Extract |
| url | http://hdl.handle.net/10725/2818 http://dx.doi.org/10.1155/2015/161720 http://www.hindawi.com/journals/ecam/2015/161720/abs/ |