Significance of microscopically incomplete resection margin after esophagectomy for esophageal cancer
Objective: The objectives of this study were to establish if R1 resection margin after esophagectomy was (i) a poor prognostic factor independent of patient and tumor characteristics, (ii) a marker of tumor aggressiveness and (iii) to look at the impact of adjuvant treatment in this subpopulation. M...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , , , |
| التنسيق: | article |
| منشور في: |
2016
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/14209 https://doi.org/10.1097/SLA.0000000000001325 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://pubmed.ncbi.nlm.nih.gov/26135681/ |
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| _version_ | 1864513469188931584 |
|---|---|
| author | Markar, Sheraz R. |
| author2 | Gronnier, Caroline Duhamel, Alain Pasquer, Arnaud Théreaux, Jérémie Du Rieu, Mael Chalret Lefevre, Jérémie H. Turner, Kathleen Luc, Guillaume Mariette, Christophe |
| author2_role | author author author author author author author author author |
| author_facet | Markar, Sheraz R. Gronnier, Caroline Duhamel, Alain Pasquer, Arnaud Théreaux, Jérémie Du Rieu, Mael Chalret Lefevre, Jérémie H. Turner, Kathleen Luc, Guillaume Mariette, Christophe |
| author_role | author |
| dc.contributor.none.fl_str_mv | Chemaly, Rodrigue |
| dc.creator.none.fl_str_mv | Markar, Sheraz R. Gronnier, Caroline Duhamel, Alain Pasquer, Arnaud Théreaux, Jérémie Du Rieu, Mael Chalret Lefevre, Jérémie H. Turner, Kathleen Luc, Guillaume Mariette, Christophe |
| dc.date.none.fl_str_mv | 2016 2022-11-03T09:34:27Z 2022-11-03T09:34:27Z 2022-11-03 |
| dc.identifier.none.fl_str_mv | 0003-4932 http://hdl.handle.net/10725/14209 https://doi.org/10.1097/SLA.0000000000001325 Markar, S. R., Gronnier, C., Duhamel, A., Pasquer, A., Théreaux, J., Rieu, M. C. D., ... & Mariette, C. (2016). Significance of microscopically incomplete resection margin after esophagectomy for esophageal cancer. Annals of surgery, 263(4), 712-718. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://pubmed.ncbi.nlm.nih.gov/26135681/ |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Annals of Surgery |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Significance of microscopically incomplete resection margin after esophagectomy for esophageal cancer |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Objective: The objectives of this study were to establish if R1 resection margin after esophagectomy was (i) a poor prognostic factor independent of patient and tumor characteristics, (ii) a marker of tumor aggressiveness and (iii) to look at the impact of adjuvant treatment in this subpopulation. Methods: Data were collected from 30 European centers from 2000 to 2010. Patients with an R1 resection margin (n = 242) were compared with those with an R0 margin (n = 2573) in terms of short- and long-term outcomes. Propensity score matching and multivariable analyses were used to compensate for differences in baseline characteristics. Results: Independent factors significantly associated with an R1 resection margin included an upper third esophageal tumor location, preoperative malnutrition, and pathological stage III. There were significant differences between the groups in postoperative histology, with an increase in pathological stage III and TRG 4–5 in the R1 group. Total average lymph node harvests were similar between the groups; however, there was an increase in the number of positive lymph nodes seen in the R1 group. Propensity matched analysis confirmed that R1 resection margin was significantly associated with reduced overall survival and increased overall, locoregional, and mixed tumor recurrence. Similar observations were seen in the subgroup that received neoadjuvant chemoradiation. In R1 patients adjuvant therapy improved survival and reduced distant recurrence however failed to affect locoregional recurrence. Conclusions: This large multicenter European study provides evidence to support the notion that R1 resection margin is a prognostic indication of aggressive tumor biology with a poor long-term prognosis. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_eddffeb4dd355f763bbdc8563c20d283 |
| identifier_str_mv | 0003-4932 Markar, S. R., Gronnier, C., Duhamel, A., Pasquer, A., Théreaux, J., Rieu, M. C. D., ... & Mariette, C. (2016). Significance of microscopically incomplete resection margin after esophagectomy for esophageal cancer. Annals of surgery, 263(4), 712-718. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/14209 |
| publishDate | 2016 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Significance of microscopically incomplete resection margin after esophagectomy for esophageal cancerMarkar, Sheraz R.Gronnier, CarolineDuhamel, AlainPasquer, ArnaudThéreaux, JérémieDu Rieu, Mael ChalretLefevre, Jérémie H.Turner, KathleenLuc, GuillaumeMariette, ChristopheObjective: The objectives of this study were to establish if R1 resection margin after esophagectomy was (i) a poor prognostic factor independent of patient and tumor characteristics, (ii) a marker of tumor aggressiveness and (iii) to look at the impact of adjuvant treatment in this subpopulation. Methods: Data were collected from 30 European centers from 2000 to 2010. Patients with an R1 resection margin (n = 242) were compared with those with an R0 margin (n = 2573) in terms of short- and long-term outcomes. Propensity score matching and multivariable analyses were used to compensate for differences in baseline characteristics. Results: Independent factors significantly associated with an R1 resection margin included an upper third esophageal tumor location, preoperative malnutrition, and pathological stage III. There were significant differences between the groups in postoperative histology, with an increase in pathological stage III and TRG 4–5 in the R1 group. Total average lymph node harvests were similar between the groups; however, there was an increase in the number of positive lymph nodes seen in the R1 group. Propensity matched analysis confirmed that R1 resection margin was significantly associated with reduced overall survival and increased overall, locoregional, and mixed tumor recurrence. Similar observations were seen in the subgroup that received neoadjuvant chemoradiation. In R1 patients adjuvant therapy improved survival and reduced distant recurrence however failed to affect locoregional recurrence. Conclusions: This large multicenter European study provides evidence to support the notion that R1 resection margin is a prognostic indication of aggressive tumor biology with a poor long-term prognosis.PublishedChemaly, Rodrigue2022-11-03T09:34:27Z2022-11-03T09:34:27Z20162022-11-03Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article0003-4932http://hdl.handle.net/10725/14209https://doi.org/10.1097/SLA.0000000000001325Markar, S. R., Gronnier, C., Duhamel, A., Pasquer, A., Théreaux, J., Rieu, M. C. D., ... & Mariette, C. (2016). Significance of microscopically incomplete resection margin after esophagectomy for esophageal cancer. Annals of surgery, 263(4), 712-718.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://pubmed.ncbi.nlm.nih.gov/26135681/enAnnals of Surgeryinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/142092022-11-03T14:49:31Z |
| spellingShingle | Significance of microscopically incomplete resection margin after esophagectomy for esophageal cancer Markar, Sheraz R. |
| status_str | publishedVersion |
| title | Significance of microscopically incomplete resection margin after esophagectomy for esophageal cancer |
| title_full | Significance of microscopically incomplete resection margin after esophagectomy for esophageal cancer |
| title_fullStr | Significance of microscopically incomplete resection margin after esophagectomy for esophageal cancer |
| title_full_unstemmed | Significance of microscopically incomplete resection margin after esophagectomy for esophageal cancer |
| title_short | Significance of microscopically incomplete resection margin after esophagectomy for esophageal cancer |
| title_sort | Significance of microscopically incomplete resection margin after esophagectomy for esophageal cancer |
| url | http://hdl.handle.net/10725/14209 https://doi.org/10.1097/SLA.0000000000001325 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://pubmed.ncbi.nlm.nih.gov/26135681/ |