Podosome rings generate forces that drive saltatory osteoclast migration
Podosomes are dynamic, actin-containing adhesion structures that collectively self-organize as rings. In this study, we first show by observing osteoclasts plated on bead-seeded soft substrates that podosome assemblies, such as rings, are involved in tension forces. During the expansion of a podosom...
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| مؤلفون آخرون: | , , , , , , , |
| التنسيق: | article |
| منشور في: |
2011
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/10339 https://doi.org/10.1091/mbc.e11-01-0086 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.molbiolcell.org/doi/full/10.1091/mbc.e11-01-0086 |
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| _version_ | 1864513486553350144 |
|---|---|
| author | Dan, Georgess |
| author2 | Hu, Shiqiong Planus, Emmanuelle Place, Christophe Wang, Xianghui Alibiges-Rizo, Corinne Jurdic, Pierre Geminard, Jean-Christophe Mogliner, Alexander |
| author2_role | author author author author author author author author |
| author_facet | Dan, Georgess Hu, Shiqiong Planus, Emmanuelle Place, Christophe Wang, Xianghui Alibiges-Rizo, Corinne Jurdic, Pierre Geminard, Jean-Christophe Mogliner, Alexander |
| author_role | author |
| dc.creator.none.fl_str_mv | Dan, Georgess Hu, Shiqiong Planus, Emmanuelle Place, Christophe Wang, Xianghui Alibiges-Rizo, Corinne Jurdic, Pierre Geminard, Jean-Christophe Mogliner, Alexander |
| dc.date.none.fl_str_mv | 2011 2019-04-04T10:12:53Z 2019-04-04T10:12:53Z 2019-04-04 |
| dc.identifier.none.fl_str_mv | 1939-4586 http://hdl.handle.net/10725/10339 https://doi.org/10.1091/mbc.e11-01-0086 Hu, S., Planus, E., Georgess, D., Place, C., Wang, X., Albiges-Rizo, C., ... & Géminard, J. C. (2011). Podosome rings generate forces that drive saltatory osteoclast migration. Molecular biology of the cell, 22(17), 3120-3126. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.molbiolcell.org/doi/full/10.1091/mbc.e11-01-0086 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Molecular Biology of the Cell |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Podosome rings generate forces that drive saltatory osteoclast migration |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Podosomes are dynamic, actin-containing adhesion structures that collectively self-organize as rings. In this study, we first show by observing osteoclasts plated on bead-seeded soft substrates that podosome assemblies, such as rings, are involved in tension forces. During the expansion of a podosome ring, substrate displacement is oriented outward, suggesting that podosomal structures push the substrate away. To further elucidate the function of forces generated by podosomes, we analyze osteoclast migration. Determining the centers of mass of the whole cell (G) and of actin (P), we demonstrate that osteoclasts migrate by “jumps” and that the trajectories of G and P are strongly correlated. The velocity of the center of mass as a function of time reveals that osteoclasts rapidly catch up with podosomal structures in a periodic pattern. We conclude that actin dynamics inside the cell are not only correlated with cell migration, but drive it. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_f36654f482c4e53a4c725353b6f7fdd3 |
| identifier_str_mv | 1939-4586 Hu, S., Planus, E., Georgess, D., Place, C., Wang, X., Albiges-Rizo, C., ... & Géminard, J. C. (2011). Podosome rings generate forces that drive saltatory osteoclast migration. Molecular biology of the cell, 22(17), 3120-3126. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/10339 |
| publishDate | 2011 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Podosome rings generate forces that drive saltatory osteoclast migrationDan, GeorgessHu, ShiqiongPlanus, EmmanuellePlace, ChristopheWang, XianghuiAlibiges-Rizo, CorinneJurdic, PierreGeminard, Jean-ChristopheMogliner, AlexanderPodosomes are dynamic, actin-containing adhesion structures that collectively self-organize as rings. In this study, we first show by observing osteoclasts plated on bead-seeded soft substrates that podosome assemblies, such as rings, are involved in tension forces. During the expansion of a podosome ring, substrate displacement is oriented outward, suggesting that podosomal structures push the substrate away. To further elucidate the function of forces generated by podosomes, we analyze osteoclast migration. Determining the centers of mass of the whole cell (G) and of actin (P), we demonstrate that osteoclasts migrate by “jumps” and that the trajectories of G and P are strongly correlated. The velocity of the center of mass as a function of time reveals that osteoclasts rapidly catch up with podosomal structures in a periodic pattern. We conclude that actin dynamics inside the cell are not only correlated with cell migration, but drive it.PublishedN/A2019-04-04T10:12:53Z2019-04-04T10:12:53Z20112019-04-04Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1939-4586http://hdl.handle.net/10725/10339https://doi.org/10.1091/mbc.e11-01-0086Hu, S., Planus, E., Georgess, D., Place, C., Wang, X., Albiges-Rizo, C., ... & Géminard, J. C. (2011). Podosome rings generate forces that drive saltatory osteoclast migration. Molecular biology of the cell, 22(17), 3120-3126.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://www.molbiolcell.org/doi/full/10.1091/mbc.e11-01-0086enMolecular Biology of the Cellinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/103392021-03-19T10:45:29Z |
| spellingShingle | Podosome rings generate forces that drive saltatory osteoclast migration Dan, Georgess |
| status_str | publishedVersion |
| title | Podosome rings generate forces that drive saltatory osteoclast migration |
| title_full | Podosome rings generate forces that drive saltatory osteoclast migration |
| title_fullStr | Podosome rings generate forces that drive saltatory osteoclast migration |
| title_full_unstemmed | Podosome rings generate forces that drive saltatory osteoclast migration |
| title_short | Podosome rings generate forces that drive saltatory osteoclast migration |
| title_sort | Podosome rings generate forces that drive saltatory osteoclast migration |
| url | http://hdl.handle.net/10725/10339 https://doi.org/10.1091/mbc.e11-01-0086 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.molbiolcell.org/doi/full/10.1091/mbc.e11-01-0086 |