Rho A and Rac1: Antagonists moving forward
Cells detect external stimuli through cell-surface receptors. In cases where the stimulus is a cytokine or a growth factor, the cell responds by inducing modifications in the actin cytoskeleton. These changes are mediated through the Rho family of GTPases. Among these GTPases, RhoA, Rac1 and Cdc42 h...
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2020
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| Online Access: | http://hdl.handle.net/10725/11879 https://doi.org/10.1016/j.tice.2020.101364 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.sciencedirect.com/science/article/pii/S0040816620300410 |
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| _version_ | 1864513489626726400 |
|---|---|
| author | Salloum, Gilbert |
| author2 | Jaafar, Leila El-Sibai, Mirvat |
| author2_role | author author |
| author_facet | Salloum, Gilbert Jaafar, Leila El-Sibai, Mirvat |
| author_role | author |
| dc.creator.none.fl_str_mv | Salloum, Gilbert Jaafar, Leila El-Sibai, Mirvat |
| dc.date.none.fl_str_mv | 2020-05-01T14:18:10Z 2020-05-01T14:18:10Z 2020 2020-05-01 |
| dc.identifier.none.fl_str_mv | 0040-8166 http://hdl.handle.net/10725/11879 https://doi.org/10.1016/j.tice.2020.101364 Salloum, G., Jaafar, L., & El-Sibai, M. (2020). Rho A and Rac1: Antagonists Moving Forward. Tissue and Cell, 65. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.sciencedirect.com/science/article/pii/S0040816620300410 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Tissue and Cell |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Rho A and Rac1: Antagonists moving forward |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Cells detect external stimuli through cell-surface receptors. In cases where the stimulus is a cytokine or a growth factor, the cell responds by inducing modifications in the actin cytoskeleton. These changes are mediated through the Rho family of GTPases. Among these GTPases, RhoA, Rac1 and Cdc42 have been extensively studied. The activity of these proteins is closely monitored and tightly regulated through Guanine-nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs) that turn the “switch” on and off respectively. Crosstalk between Rho GTPases has been long studied; yet many questions are raised regarding the spatiotemporal regulation of these GTPases, particularly RhoA and Rac1. This review sheds a light on the antagonistic relationship between both GTPases and puts emphasis on the importance of cycling of RhoA activation at the focal adhesions for optimal cell migration. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_f3f9ef1fbbbe03af9b32b264a4501385 |
| identifier_str_mv | 0040-8166 Salloum, G., Jaafar, L., & El-Sibai, M. (2020). Rho A and Rac1: Antagonists Moving Forward. Tissue and Cell, 65. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/11879 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Rho A and Rac1: Antagonists moving forwardSalloum, GilbertJaafar, LeilaEl-Sibai, MirvatCells detect external stimuli through cell-surface receptors. In cases where the stimulus is a cytokine or a growth factor, the cell responds by inducing modifications in the actin cytoskeleton. These changes are mediated through the Rho family of GTPases. Among these GTPases, RhoA, Rac1 and Cdc42 have been extensively studied. The activity of these proteins is closely monitored and tightly regulated through Guanine-nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs) that turn the “switch” on and off respectively. Crosstalk between Rho GTPases has been long studied; yet many questions are raised regarding the spatiotemporal regulation of these GTPases, particularly RhoA and Rac1. This review sheds a light on the antagonistic relationship between both GTPases and puts emphasis on the importance of cycling of RhoA activation at the focal adhesions for optimal cell migration.PublishedN/A2020-05-01T14:18:10Z2020-05-01T14:18:10Z20202020-05-01Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article0040-8166http://hdl.handle.net/10725/11879https://doi.org/10.1016/j.tice.2020.101364Salloum, G., Jaafar, L., & El-Sibai, M. (2020). Rho A and Rac1: Antagonists Moving Forward. Tissue and Cell, 65.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://www.sciencedirect.com/science/article/pii/S0040816620300410enTissue and Cellinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/118792026-02-19T07:51:27Z |
| spellingShingle | Rho A and Rac1: Antagonists moving forward Salloum, Gilbert |
| status_str | publishedVersion |
| title | Rho A and Rac1: Antagonists moving forward |
| title_full | Rho A and Rac1: Antagonists moving forward |
| title_fullStr | Rho A and Rac1: Antagonists moving forward |
| title_full_unstemmed | Rho A and Rac1: Antagonists moving forward |
| title_short | Rho A and Rac1: Antagonists moving forward |
| title_sort | Rho A and Rac1: Antagonists moving forward |
| url | http://hdl.handle.net/10725/11879 https://doi.org/10.1016/j.tice.2020.101364 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.sciencedirect.com/science/article/pii/S0040816620300410 |