In vitro ischemia suppresses hypoxic induction of hypoxia-inducible factor-1α by inhibition of synthesis and not enhanced degradation
Hypoxia-inducible factor (HIF) mediates a broad, conserved adaptive response to hypoxia, and the HIF pathway is a potential therapeutic target in cerebral ischemia. This study investigated the mechanism by which in vitro ischemia (oxygen-glucose deprivation; OGD) affects canonical hypoxic HIF-1α sta...
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| Format: | article |
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2013
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| Online Access: | http://hdl.handle.net/10725/6137 http://dx.doi.org/10.1002/jnr.23204 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php |
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