Patients with familial biparental hydatidiform moles have normal methylation at imprinted genes
In molar tissues from patients with recurrent biparental hydatidiform moles, we could previously demonstrate that differentially methylated regions (DMRs) of four imprinted genes are abnormally methylated on the maternal alleles. It remained unclear if this abnormal methylation originated de novo in...
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| مؤلفون آخرون: | , , , , , |
| التنسيق: | article |
| منشور في: |
2005
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/6172 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://search.proquest.com/docview/217840954?pq-origsite=gscholar |
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| _version_ | 1864513478630309888 |
|---|---|
| author | El Maarri, Osman |
| author2 | Seoud, Muhieddine Riviere, Jean-Baptiste Oldenburg, Johannes Walter, Jorn Rouleau, Guy Slim, Rima |
| author2_role | author author author author author author |
| author_facet | El Maarri, Osman Seoud, Muhieddine Riviere, Jean-Baptiste Oldenburg, Johannes Walter, Jorn Rouleau, Guy Slim, Rima |
| author_role | author |
| dc.creator.none.fl_str_mv | El Maarri, Osman Seoud, Muhieddine Riviere, Jean-Baptiste Oldenburg, Johannes Walter, Jorn Rouleau, Guy Slim, Rima |
| dc.date.none.fl_str_mv | 2005 2017-09-13T06:25:19Z 2017-09-13T06:25:19Z 2017-09-13 |
| dc.identifier.none.fl_str_mv | 1476-5438 http://hdl.handle.net/10725/6172 El-Maarri, O., Seoud, M., Rivière, J. B., Oldenburg, J., Walter, J., Rouleau, G., & Slim, R. (2005). Patients with familial biparental hydatidiform moles have normal methylation at imprinted genes. European journal of human genetics: EJHG, 13(4), 486. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://search.proquest.com/docview/217840954?pq-origsite=gscholar |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | European Journal of Human Genetics |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Patients with familial biparental hydatidiform moles have normal methylation at imprinted genes |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | In molar tissues from patients with recurrent biparental hydatidiform moles, we could previously demonstrate that differentially methylated regions (DMRs) of four imprinted genes are abnormally methylated on the maternal alleles. It remained unclear if this abnormal methylation originated de novo in the molar tissues or if it is even recognizable in the patient somatic tissues. To address this question, we investigated the DNA methylation of four imprinted genes in total blood from the two sister-patients. Here, we show that both patients retain normal methylation levels at the DMRs of the four genes in blood tissues. For two maternally expressed genes, we could use informative SNPs to follow the inheritance of the abnormally methylated maternal alleles in the molar tissues. We find that the transmitted abnormally methylated maternal alleles to the moles originated from the maternal grandmother and that the same alleles are not methylated in the patients. Our data suggest that the abnormal methylation in familial biparental molar tissues was acquired de novo in the patients’germline as a result of a false reprogramming or during the postzygotic development of the conceptuses that led to moles. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_f4506cddfe78036bde545e4606fb67c8 |
| identifier_str_mv | 1476-5438 El-Maarri, O., Seoud, M., Rivière, J. B., Oldenburg, J., Walter, J., Rouleau, G., & Slim, R. (2005). Patients with familial biparental hydatidiform moles have normal methylation at imprinted genes. European journal of human genetics: EJHG, 13(4), 486. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/6172 |
| publishDate | 2005 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Patients with familial biparental hydatidiform moles have normal methylation at imprinted genesEl Maarri, OsmanSeoud, MuhieddineRiviere, Jean-BaptisteOldenburg, JohannesWalter, JornRouleau, GuySlim, RimaIn molar tissues from patients with recurrent biparental hydatidiform moles, we could previously demonstrate that differentially methylated regions (DMRs) of four imprinted genes are abnormally methylated on the maternal alleles. It remained unclear if this abnormal methylation originated de novo in the molar tissues or if it is even recognizable in the patient somatic tissues. To address this question, we investigated the DNA methylation of four imprinted genes in total blood from the two sister-patients. Here, we show that both patients retain normal methylation levels at the DMRs of the four genes in blood tissues. For two maternally expressed genes, we could use informative SNPs to follow the inheritance of the abnormally methylated maternal alleles in the molar tissues. We find that the transmitted abnormally methylated maternal alleles to the moles originated from the maternal grandmother and that the same alleles are not methylated in the patients. Our data suggest that the abnormal methylation in familial biparental molar tissues was acquired de novo in the patients’germline as a result of a false reprogramming or during the postzygotic development of the conceptuses that led to moles.PublishedN/A2017-09-13T06:25:19Z2017-09-13T06:25:19Z20052017-09-13Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1476-5438http://hdl.handle.net/10725/6172El-Maarri, O., Seoud, M., Rivière, J. B., Oldenburg, J., Walter, J., Rouleau, G., & Slim, R. (2005). Patients with familial biparental hydatidiform moles have normal methylation at imprinted genes. European journal of human genetics: EJHG, 13(4), 486.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://search.proquest.com/docview/217840954?pq-origsite=gscholarenEuropean Journal of Human Geneticsinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/61722021-03-19T10:00:49Z |
| spellingShingle | Patients with familial biparental hydatidiform moles have normal methylation at imprinted genes El Maarri, Osman |
| status_str | publishedVersion |
| title | Patients with familial biparental hydatidiform moles have normal methylation at imprinted genes |
| title_full | Patients with familial biparental hydatidiform moles have normal methylation at imprinted genes |
| title_fullStr | Patients with familial biparental hydatidiform moles have normal methylation at imprinted genes |
| title_full_unstemmed | Patients with familial biparental hydatidiform moles have normal methylation at imprinted genes |
| title_short | Patients with familial biparental hydatidiform moles have normal methylation at imprinted genes |
| title_sort | Patients with familial biparental hydatidiform moles have normal methylation at imprinted genes |
| url | http://hdl.handle.net/10725/6172 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://search.proquest.com/docview/217840954?pq-origsite=gscholar |