HMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell niche
High-mobility group A1 (Hmga1) chromatin remodelling proteins are enriched in intestinal stem cells (ISCs), although their function in this setting was unknown. Prior studies showed that Hmga1 drives hyperproliferation, aberrant crypt formation and polyposis in transgenic mice. Here we demonstrate t...
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| Other Authors: | , , , , |
| Format: | article |
| Published: |
2017
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| Online Access: | http://hdl.handle.net/10725/10347 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.nature.com/articles/ncomms15008 |
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