β-2-himachalen-6-ol
Daucus carota ssp. carota, also known as wild carrot, is a commonly used herb in Lebanese folk medicine to treat several ailments including cancer. Previous studies in our laboratories showed that the Daucus carota oil extract (DCOE) and subsequent fractions exhibit antioxidant, anti-inflammatory an...
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| مؤلفون آخرون: | , , , , , , , |
| التنسيق: | article |
| منشور في: |
2016
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/4582 http://dx.doi.org/10.1016/j.jep.2016.05.053 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.sciencedirect.com/science/article/pii/S0378874116303336 |
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إضافة وسم
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| _version_ | 1864513464034131968 |
|---|---|
| author | Taleb, Robin I. |
| author2 | Najm, Paul Shebaby, Wassim Boulos, Joelle C. Demirdjian, Sally Hariri, Essa El-Sibai, Mirvat Daher, Costantine Mroueh, Mohamad |
| author2_role | author author author author author author author author |
| author_facet | Taleb, Robin I. Najm, Paul Shebaby, Wassim Boulos, Joelle C. Demirdjian, Sally Hariri, Essa El-Sibai, Mirvat Daher, Costantine Mroueh, Mohamad |
| author_role | author |
| dc.creator.none.fl_str_mv | Taleb, Robin I. Najm, Paul Shebaby, Wassim Boulos, Joelle C. Demirdjian, Sally Hariri, Essa El-Sibai, Mirvat Daher, Costantine Mroueh, Mohamad |
| dc.date.none.fl_str_mv | 2016-10-13T06:39:54Z 2016-10-13T06:39:54Z 2016 2016-10-13 |
| dc.identifier.none.fl_str_mv | 0378-8741 http://hdl.handle.net/10725/4582 http://dx.doi.org/10.1016/j.jep.2016.05.053 Taleb, R. I., Najm, P., Shebaby, W., Boulos, J. C., Demirdjian, S., Hariri, E., ... & Mroueh, M. (2016). β-2-himachalen-6-ol: A novel anticancer sesquiterpene unique to the Lebanese wild carrot. Journal of ethnopharmacology, 190, 59-67. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.sciencedirect.com/science/article/pii/S0378874116303336 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Journal of Ethnopharmacology |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | β-2-himachalen-6-ol a novel anticancer sesquiterpene unique to the Lebanese wild carrot |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Daucus carota ssp. carota, also known as wild carrot, is a commonly used herb in Lebanese folk medicine to treat several ailments including cancer. Previous studies in our laboratories showed that the Daucus carota oil extract (DCOE) and subsequent fractions exhibit antioxidant, anti-inflammatory and anti-cancer activities. In this study, we report the isolation and identification of the major compound responsible for the anti-cancer activity of DCOE along with the mechanism of action involved. GC–MS and NMR spectroscopy revealed the identity of the major compound as β-2-himachalen-6-ol, a novel sesquiterpene unique to the Lebanese wild carrot. β-2-Himachalen-6-ol demonstrated potent anti-cancer activity against B16F-10, Caco-2, MB-MDA-231, A549 and SF-268 cancer cells (IC50 13–4 µg/ml; 58–18 µM), with SF-268 cells being the most sensitive. The sesquiterpene was shown to induce cell death through apoptosis (flow cytometry), decrease 2D cell motility (wound healing assay) and 3D invasion, as well as increase cell adhesion in SF-268 cells. Additionally, β-2-himachalen-6-ol showed very low toxicity in mice with an LD50>6000 mg/kg body weight. In conclusion, the present data demonstrate that β-2-himachalen-6-ol is a potential multi-mechanistic chemotherapeutic drug with high potency and safety. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_f8ee35a2c0c0cccc993eeeb06f7a8bdd |
| identifier_str_mv | 0378-8741 Taleb, R. I., Najm, P., Shebaby, W., Boulos, J. C., Demirdjian, S., Hariri, E., ... & Mroueh, M. (2016). β-2-himachalen-6-ol: A novel anticancer sesquiterpene unique to the Lebanese wild carrot. Journal of ethnopharmacology, 190, 59-67. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/4582 |
| publishDate | 2016 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | β-2-himachalen-6-ola novel anticancer sesquiterpene unique to the Lebanese wild carrotTaleb, Robin I.Najm, PaulShebaby, WassimBoulos, Joelle C.Demirdjian, SallyHariri, EssaEl-Sibai, MirvatDaher, CostantineMroueh, MohamadDaucus carota ssp. carota, also known as wild carrot, is a commonly used herb in Lebanese folk medicine to treat several ailments including cancer. Previous studies in our laboratories showed that the Daucus carota oil extract (DCOE) and subsequent fractions exhibit antioxidant, anti-inflammatory and anti-cancer activities. In this study, we report the isolation and identification of the major compound responsible for the anti-cancer activity of DCOE along with the mechanism of action involved. GC–MS and NMR spectroscopy revealed the identity of the major compound as β-2-himachalen-6-ol, a novel sesquiterpene unique to the Lebanese wild carrot. β-2-Himachalen-6-ol demonstrated potent anti-cancer activity against B16F-10, Caco-2, MB-MDA-231, A549 and SF-268 cancer cells (IC50 13–4 µg/ml; 58–18 µM), with SF-268 cells being the most sensitive. The sesquiterpene was shown to induce cell death through apoptosis (flow cytometry), decrease 2D cell motility (wound healing assay) and 3D invasion, as well as increase cell adhesion in SF-268 cells. Additionally, β-2-himachalen-6-ol showed very low toxicity in mice with an LD50>6000 mg/kg body weight. In conclusion, the present data demonstrate that β-2-himachalen-6-ol is a potential multi-mechanistic chemotherapeutic drug with high potency and safety.PublishedN/A2016-10-13T06:39:54Z2016-10-13T06:39:54Z20162016-10-13Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article0378-8741http://hdl.handle.net/10725/4582http://dx.doi.org/10.1016/j.jep.2016.05.053Taleb, R. I., Najm, P., Shebaby, W., Boulos, J. C., Demirdjian, S., Hariri, E., ... & Mroueh, M. (2016). β-2-himachalen-6-ol: A novel anticancer sesquiterpene unique to the Lebanese wild carrot. Journal of ethnopharmacology, 190, 59-67.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttp://www.sciencedirect.com/science/article/pii/S0378874116303336enJournal of Ethnopharmacologyinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/45822024-02-01T13:40:05Z |
| spellingShingle | β-2-himachalen-6-ol Taleb, Robin I. |
| status_str | publishedVersion |
| title | β-2-himachalen-6-ol |
| title_full | β-2-himachalen-6-ol |
| title_fullStr | β-2-himachalen-6-ol |
| title_full_unstemmed | β-2-himachalen-6-ol |
| title_short | β-2-himachalen-6-ol |
| title_sort | β-2-himachalen-6-ol |
| url | http://hdl.handle.net/10725/4582 http://dx.doi.org/10.1016/j.jep.2016.05.053 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.sciencedirect.com/science/article/pii/S0378874116303336 |