An enantioselective synthesis of β2-amino acid derivatives
Enantioselective hydrogenation of a series of (E)-α-substituted β-amidoacrylates using Rh(I)-catalysts with chiral phosphine ligands (BPE, DuPHOS) gives β2-amino acid derivatives with enantioselectivities of up to 67%. A β2,3-amino acid derivative was also synthesised with similar enantioselectivity...
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| Other Authors: | , , , |
| Format: | article |
| Published: |
2005
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| Online Access: | http://hdl.handle.net/10725/2867 http://dx.doi.org/10.1016/j.tetasy.2005.01.048 http://www.sciencedirect.com/science/article/pii/S0957416605001473 |
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| Summary: | Enantioselective hydrogenation of a series of (E)-α-substituted β-amidoacrylates using Rh(I)-catalysts with chiral phosphine ligands (BPE, DuPHOS) gives β2-amino acid derivatives with enantioselectivities of up to 67%. A β2,3-amino acid derivative was also synthesised with similar enantioselectivity (⩽65%) from the corresponding prochiral enamide. |
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