Systemic anthrax lethal toxin therapy produces regressions of subcutaneous human melanoma tumors in athymic nude mice

Systemic anthrax lethal toxin therapy produces regressions of subcutaneous human melanoma tumors in athymic nude mice

Purpose: Anthrax Lethal Toxin (LeTx), composed of protective antigen and lethal factor, catalytically cleaves mitogen-activated protein kinase (MAPK) kinases and inhibits the MAPK signaling pathways. The majority of metastatic melanomas possess the V599E BRAF mutation, which constitutively activates...

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Bibliographic Details
Main Author:	Abi-Habib, Ralph J. (author)
Other Authors:	Singh, Ravibhushan (author), Leppla, Stephen H. (author), Greene, John J. (author), Ding, Yan (author), Berghuis, Bree (author), Duesbery, Nicholas S. (author), Frankel, Arthur E. (author)
Format:	article
Published:	2006
Online Access:	http://hdl.handle.net/10725/2735 http://dx.doi.org/ 10.1158/1078-0432.CCR-06-2019 http://www.ncbi.nlm.nih.gov/pubmed/17189417
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