Stimulation of postprandial in vivo glycogenesis and lipogenesis of rats fed high fructose diet with varied phosphate content
It has been reported that increased fructose intake is associated with the development of the metabolic syndrome. The phosphate (P) sequestering capacity of fructose is likely to affect the phosphorylation capacity of different metabolites, and this, in turn, may be the basis for several metabolic d...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , |
| التنسيق: | article |
| منشور في: |
2010
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/6228 https://doi.org/10.1016/j.nutres.2009.12.004 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.sciencedirect.com/science/article/pii/S0271531709002541 |
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| _version_ | 1864513478926008320 |
|---|---|
| author | Mattar, Lama E. |
| author2 | Mattar, Melanie A. Mouneimne, Youssef Obeid, Omar A. |
| author2_role | author author author |
| author_facet | Mattar, Lama E. Mattar, Melanie A. Mouneimne, Youssef Obeid, Omar A. |
| author_role | author |
| dc.creator.none.fl_str_mv | Mattar, Lama E. Mattar, Melanie A. Mouneimne, Youssef Obeid, Omar A. |
| dc.date.none.fl_str_mv | 2010 2017-09-20T09:51:06Z 2017-09-20T09:51:06Z 2017-09-20 |
| dc.identifier.none.fl_str_mv | 1879-0739 http://hdl.handle.net/10725/6228 https://doi.org/10.1016/j.nutres.2009.12.004 Mattar, L. E., Mattar, M. A., Batal, M., Mouneimne, Y., & Obeid, O. A. (2010). Stimulation of postprandial in vivo glycogenesis and lipogenesis of rats fed high fructose diet with varied phosphate content. Nutrition research, 30(2), 151-155. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.sciencedirect.com/science/article/pii/S0271531709002541 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Nutrition Research |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Stimulation of postprandial in vivo glycogenesis and lipogenesis of rats fed high fructose diet with varied phosphate content |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | It has been reported that increased fructose intake is associated with the development of the metabolic syndrome. The phosphate (P) sequestering capacity of fructose is likely to affect the phosphorylation capacity of different metabolites, and this, in turn, may be the basis for several metabolic derangements, especially in the P requiring reactions, for example, glycogenesis and lipogenesis. We hypothesized that P enrichment of the diet can balance P status and, consequently, affect glycogenesis and lipogenesis. An animal experiment was executed in which adult male Sprague-Dawley rats were maintained for 4 days on high-fructose diets with different P content (0.15%, 0.165%, 0.30%, and 1.65%). At the end of the feeding period, overnight fasted rats were tube fed a test meal, injected with 3H2O and euthanized 1 hour later. Final plasma glucose, insulin, uric acid, and triacylglycerol concentrations, as well as in vivo rates of glycogen and lipid synthesis and hepatic glycogen content, were measured. Results showed that increased P content of the diet was associated with an increase in postprandial epididymal fat pad (P = .007) and hepatic lipogenesis (P = .029), as well as glycogenesis (P = .024). In conclusion, P content of the diet was found to stimulate both glycogenesis and lipogenesis. These alterations in carbohydrate and fat metabolism point to the potential of P in influencing nutritional status. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_ff9cdd2519261a70615ce2e32fdd2de5 |
| identifier_str_mv | 1879-0739 Mattar, L. E., Mattar, M. A., Batal, M., Mouneimne, Y., & Obeid, O. A. (2010). Stimulation of postprandial in vivo glycogenesis and lipogenesis of rats fed high fructose diet with varied phosphate content. Nutrition research, 30(2), 151-155. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/6228 |
| publishDate | 2010 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Stimulation of postprandial in vivo glycogenesis and lipogenesis of rats fed high fructose diet with varied phosphate contentMattar, Lama E.Mattar, Melanie A.Mouneimne, YoussefObeid, Omar A.It has been reported that increased fructose intake is associated with the development of the metabolic syndrome. The phosphate (P) sequestering capacity of fructose is likely to affect the phosphorylation capacity of different metabolites, and this, in turn, may be the basis for several metabolic derangements, especially in the P requiring reactions, for example, glycogenesis and lipogenesis. We hypothesized that P enrichment of the diet can balance P status and, consequently, affect glycogenesis and lipogenesis. An animal experiment was executed in which adult male Sprague-Dawley rats were maintained for 4 days on high-fructose diets with different P content (0.15%, 0.165%, 0.30%, and 1.65%). At the end of the feeding period, overnight fasted rats were tube fed a test meal, injected with 3H2O and euthanized 1 hour later. Final plasma glucose, insulin, uric acid, and triacylglycerol concentrations, as well as in vivo rates of glycogen and lipid synthesis and hepatic glycogen content, were measured. Results showed that increased P content of the diet was associated with an increase in postprandial epididymal fat pad (P = .007) and hepatic lipogenesis (P = .029), as well as glycogenesis (P = .024). In conclusion, P content of the diet was found to stimulate both glycogenesis and lipogenesis. These alterations in carbohydrate and fat metabolism point to the potential of P in influencing nutritional status.PublishedN/A2017-09-20T09:51:06Z2017-09-20T09:51:06Z20102017-09-20Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1879-0739http://hdl.handle.net/10725/6228https://doi.org/10.1016/j.nutres.2009.12.004Mattar, L. E., Mattar, M. A., Batal, M., Mouneimne, Y., & Obeid, O. A. (2010). Stimulation of postprandial in vivo glycogenesis and lipogenesis of rats fed high fructose diet with varied phosphate content. Nutrition research, 30(2), 151-155.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttp://www.sciencedirect.com/science/article/pii/S0271531709002541enNutrition Researchinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/62282021-03-19T10:43:18Z |
| spellingShingle | Stimulation of postprandial in vivo glycogenesis and lipogenesis of rats fed high fructose diet with varied phosphate content Mattar, Lama E. |
| status_str | publishedVersion |
| title | Stimulation of postprandial in vivo glycogenesis and lipogenesis of rats fed high fructose diet with varied phosphate content |
| title_full | Stimulation of postprandial in vivo glycogenesis and lipogenesis of rats fed high fructose diet with varied phosphate content |
| title_fullStr | Stimulation of postprandial in vivo glycogenesis and lipogenesis of rats fed high fructose diet with varied phosphate content |
| title_full_unstemmed | Stimulation of postprandial in vivo glycogenesis and lipogenesis of rats fed high fructose diet with varied phosphate content |
| title_short | Stimulation of postprandial in vivo glycogenesis and lipogenesis of rats fed high fructose diet with varied phosphate content |
| title_sort | Stimulation of postprandial in vivo glycogenesis and lipogenesis of rats fed high fructose diet with varied phosphate content |
| url | http://hdl.handle.net/10725/6228 https://doi.org/10.1016/j.nutres.2009.12.004 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.sciencedirect.com/science/article/pii/S0271531709002541 |