Targeting HER2-positive breast cancer cells by a combination of dasatinib and BMS-202: Insight into the molecular pathways
<h3>Background</h3><p dir="ltr">Recent investigations have reported the benefits of using a tyrosine kinase inhibitor, dasatinib (DA), as well as programmed death-ligand 1 (PD-L1) inhibitors in the management of several solid tumors, including breast cancer. Nevertheless,...
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| مؤلفون آخرون: | , , , , , , |
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2024
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| _version_ | 1864513545095348224 |
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| author | Hadeel Kheraldine (14231609) |
| author2 | Ishita Gupta (9203073) Farhan Sachal Cyprian (21633524) Semir Vranic (3353012) Halema F. Al-Farsi (21259523) Maysaloun Merhi (4246147) Said Dermime (79420) Ala-Eddin Al Moustafa (14153205) |
| author2_role | author author author author author author author |
| author_facet | Hadeel Kheraldine (14231609) Ishita Gupta (9203073) Farhan Sachal Cyprian (21633524) Semir Vranic (3353012) Halema F. Al-Farsi (21259523) Maysaloun Merhi (4246147) Said Dermime (79420) Ala-Eddin Al Moustafa (14153205) |
| author_role | author |
| dc.creator.none.fl_str_mv | Hadeel Kheraldine (14231609) Ishita Gupta (9203073) Farhan Sachal Cyprian (21633524) Semir Vranic (3353012) Halema F. Al-Farsi (21259523) Maysaloun Merhi (4246147) Said Dermime (79420) Ala-Eddin Al Moustafa (14153205) |
| dc.date.none.fl_str_mv | 2024-03-02T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1186/s12935-023-03195-z |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Targeting_HER2-positive_breast_cancer_cells_by_a_combination_of_dasatinib_and_BMS-202_Insight_into_the_molecular_pathways/29446055 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Dasatinib PD-1/PD-L1 HER2-positive breast cancer EMT Invasion |
| dc.title.none.fl_str_mv | Targeting HER2-positive breast cancer cells by a combination of dasatinib and BMS-202: Insight into the molecular pathways |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">Recent investigations have reported the benefits of using a tyrosine kinase inhibitor, dasatinib (DA), as well as programmed death-ligand 1 (PD-L1) inhibitors in the management of several solid tumors, including breast cancer. Nevertheless, the outcome of the combination of these inhibitors on HER2-positive breast cancer is not explored yet.</p><h3>Methods</h3><p dir="ltr">Herein, we investigated the impact of DA and PD-L1 inhibitor (BMS-202) combination on HER2-positive breast cancer cell lines, SKBR3 and ZR75.</p><h3>Results</h3><p dir="ltr">Our data reveal that the combination significantly inhibits cell viability of both cancer cell lines as compared to monotreatment. Moreover, the combination inhibits epithelial-mesenchymal transition (EMT) progression and reduces cancer cell invasion by restoring E-cadherin and β-catenin expressions and loss of vimentin, major biomarkers of EMT. Additionally, the combination reduces the colony formation of both cell lines in comparison with their matched control. Also, the combination considerably inhibits the angiogenesis of the chorioallantoic membrane model compared with monotreatment. Molecular pathway analysis of treated cells shows that this combination blocks HER2, AKT, β-catenin, and JNK1/2/3 activities.</p><h3>Conclusion</h3><p dir="ltr">Our findings implicate that a combination of DA and BMS-202 could have a significant impact on the management of HER2-positive breast cancer.</p><h2>Other Information</h2><p dir="ltr">Published in: Cancer Cell International<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s12935-023-03195-z" target="_blank">https://dx.doi.org/10.1186/s12935-023-03195-z</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_002a05321d3080a4cd081b03f82484fd |
| identifier_str_mv | 10.1186/s12935-023-03195-z |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/29446055 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Targeting HER2-positive breast cancer cells by a combination of dasatinib and BMS-202: Insight into the molecular pathwaysHadeel Kheraldine (14231609)Ishita Gupta (9203073)Farhan Sachal Cyprian (21633524)Semir Vranic (3353012)Halema F. Al-Farsi (21259523)Maysaloun Merhi (4246147)Said Dermime (79420)Ala-Eddin Al Moustafa (14153205)Biomedical and clinical sciencesOncology and carcinogenesisPharmacology and pharmaceutical sciencesDasatinibPD-1/PD-L1HER2-positive breast cancerEMTInvasion<h3>Background</h3><p dir="ltr">Recent investigations have reported the benefits of using a tyrosine kinase inhibitor, dasatinib (DA), as well as programmed death-ligand 1 (PD-L1) inhibitors in the management of several solid tumors, including breast cancer. Nevertheless, the outcome of the combination of these inhibitors on HER2-positive breast cancer is not explored yet.</p><h3>Methods</h3><p dir="ltr">Herein, we investigated the impact of DA and PD-L1 inhibitor (BMS-202) combination on HER2-positive breast cancer cell lines, SKBR3 and ZR75.</p><h3>Results</h3><p dir="ltr">Our data reveal that the combination significantly inhibits cell viability of both cancer cell lines as compared to monotreatment. Moreover, the combination inhibits epithelial-mesenchymal transition (EMT) progression and reduces cancer cell invasion by restoring E-cadherin and β-catenin expressions and loss of vimentin, major biomarkers of EMT. Additionally, the combination reduces the colony formation of both cell lines in comparison with their matched control. Also, the combination considerably inhibits the angiogenesis of the chorioallantoic membrane model compared with monotreatment. Molecular pathway analysis of treated cells shows that this combination blocks HER2, AKT, β-catenin, and JNK1/2/3 activities.</p><h3>Conclusion</h3><p dir="ltr">Our findings implicate that a combination of DA and BMS-202 could have a significant impact on the management of HER2-positive breast cancer.</p><h2>Other Information</h2><p dir="ltr">Published in: Cancer Cell International<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s12935-023-03195-z" target="_blank">https://dx.doi.org/10.1186/s12935-023-03195-z</a></p>2024-03-02T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1186/s12935-023-03195-zhttps://figshare.com/articles/journal_contribution/Targeting_HER2-positive_breast_cancer_cells_by_a_combination_of_dasatinib_and_BMS-202_Insight_into_the_molecular_pathways/29446055CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/294460552024-03-02T03:00:00Z |
| spellingShingle | Targeting HER2-positive breast cancer cells by a combination of dasatinib and BMS-202: Insight into the molecular pathways Hadeel Kheraldine (14231609) Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Dasatinib PD-1/PD-L1 HER2-positive breast cancer EMT Invasion |
| status_str | publishedVersion |
| title | Targeting HER2-positive breast cancer cells by a combination of dasatinib and BMS-202: Insight into the molecular pathways |
| title_full | Targeting HER2-positive breast cancer cells by a combination of dasatinib and BMS-202: Insight into the molecular pathways |
| title_fullStr | Targeting HER2-positive breast cancer cells by a combination of dasatinib and BMS-202: Insight into the molecular pathways |
| title_full_unstemmed | Targeting HER2-positive breast cancer cells by a combination of dasatinib and BMS-202: Insight into the molecular pathways |
| title_short | Targeting HER2-positive breast cancer cells by a combination of dasatinib and BMS-202: Insight into the molecular pathways |
| title_sort | Targeting HER2-positive breast cancer cells by a combination of dasatinib and BMS-202: Insight into the molecular pathways |
| topic | Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Dasatinib PD-1/PD-L1 HER2-positive breast cancer EMT Invasion |