Tau deletion promotes brain insulin resistance

Tau deletion promotes brain insulin resistance

<p dir="ltr">The molecular pathways underlying tau pathology–induced synaptic/cognitive deficits and neurodegeneration are poorly understood. One prevalent hypothesis is that hyperphosphorylation, misfolding, and fibrillization of tau impair synaptic plasticity and cause degeneration...

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Main Author: Elodie Marciniak (18892114) (author)
Other Authors: Antoine Leboucher (7454165) (author), Emilie Caron (11899199) (author), Tariq Ahmed (5768081) (author), Anne Tailleux (330488) (author), Julie Dumont (224385) (author), Tarik Issad (149334) (author), Ellen Gerhardt (185546) (author), Patrick Pagesy (149321) (author), Margaux Vileno (18892117) (author), Clément Bournonville (18892120) (author), Malika Hamdane (373776) (author), Kadiombo Bantubungi (330472) (author), Steve Lancel (146004) (author), Dominique Demeyer (75873) (author), Sabiha Eddarkaoui (1618621) (author), Emmanuelle Vallez (4006400) (author), Didier Vieau (122216) (author), Sandrine Humez (18892123) (author), Emilie Faivre (5507582) (author), Benjamin Grenier-Boley (577027) (author), Tiago F. Outeiro (191379) (author), Bart Staels (15303) (author), Philippe Amouyel (161598) (author), Detlef Balschun (8096618) (author), Luc Buee (16270421) (author), David Blum (344593) (author)
Published: 2017
Subjects:
Biomedical and clinical sciences
Neurosciences
Tau pathology
Synaptic plasticity
Hyperphosphorylation
Insulin signaling
Cognitive deficits
Neurodegeneration
Alzheimer's disease
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