Genetics of glutamate and its receptors in autism spectrum disorder
<p>Autism spectrum disorder (ASD) is a neurodevelopmental impairment characterized by deficits in social interaction skills, impaired communication, and repetitive and restricted behaviors that are thought to be due to altered neurotransmission processes. The amino acid glutamate is an essenti...
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2022
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| author | Sabah Nisar (12561961) |
| author2 | Ajaz A. Bhat (12984701) Tariq Masoodi (8117702) Sheema Hashem (14150961) Sabah Akhtar (5809925) Tayyiba Akbar Ali (14152572) Sara Amjad (14152575) Sanjeev Chawla (771773) Puneet Bagga (4055866) Michael P. Frenneaux (9538623) Ravinder Reddy (564813) Khalid Fakhro (3441305) Mohammad Haris (564809) |
| author2_role | author author author author author author author author author author author author |
| author_facet | Sabah Nisar (12561961) Ajaz A. Bhat (12984701) Tariq Masoodi (8117702) Sheema Hashem (14150961) Sabah Akhtar (5809925) Tayyiba Akbar Ali (14152572) Sara Amjad (14152575) Sanjeev Chawla (771773) Puneet Bagga (4055866) Michael P. Frenneaux (9538623) Ravinder Reddy (564813) Khalid Fakhro (3441305) Mohammad Haris (564809) |
| author_role | author |
| dc.creator.none.fl_str_mv | Sabah Nisar (12561961) Ajaz A. Bhat (12984701) Tariq Masoodi (8117702) Sheema Hashem (14150961) Sabah Akhtar (5809925) Tayyiba Akbar Ali (14152572) Sara Amjad (14152575) Sanjeev Chawla (771773) Puneet Bagga (4055866) Michael P. Frenneaux (9538623) Ravinder Reddy (564813) Khalid Fakhro (3441305) Mohammad Haris (564809) |
| dc.date.none.fl_str_mv | 2022-11-22T21:16:36Z |
| dc.identifier.none.fl_str_mv | 10.1038/s41380-022-01506-w |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Genetics_of_glutamate_and_its_receptors_in_autism_spectrum_disorder/21598038 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Clinical sciences Neurosciences Cellular and Molecular Neuroscience Psychiatry and Mental health Molecular Biology |
| dc.title.none.fl_str_mv | Genetics of glutamate and its receptors in autism spectrum disorder |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p>Autism spectrum disorder (ASD) is a neurodevelopmental impairment characterized by deficits in social interaction skills, impaired communication, and repetitive and restricted behaviors that are thought to be due to altered neurotransmission processes. The amino acid glutamate is an essential excitatory neurotransmitter in the human brain that regulates cognitive functions such as learning and memory, which are usually impaired in ASD. Over the last several years, increasing evidence from genetics, neuroimaging, protein expression, and animal model studies supporting the notion of altered glutamate metabolism has heightened the interest in evaluating glutamatergic dysfunction in ASD. Numerous pharmacological, behavioral, and imaging studies have demonstrated the imbalance in excitatory and inhibitory neurotransmitters, thus revealing the involvement of the glutamatergic system in ASD pathology. Here, we review the effects of genetic alterations on glutamate and its receptors in ASD and the role of non-invasive imaging modalities in detecting these changes. We also highlight the potential therapeutic targets associated with impaired glutamatergic pathways.</p><h2>Other Information</h2> <p> Published in: Molecular Psychiatry<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1038/s41380-022-01506-w" target="_blank">http://dx.doi.org/10.1038/s41380-022-01506-w</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_00ea9f4d893ffb43c8b8c780743f801d |
| identifier_str_mv | 10.1038/s41380-022-01506-w |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/21598038 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Genetics of glutamate and its receptors in autism spectrum disorderSabah Nisar (12561961)Ajaz A. Bhat (12984701)Tariq Masoodi (8117702)Sheema Hashem (14150961)Sabah Akhtar (5809925)Tayyiba Akbar Ali (14152572)Sara Amjad (14152575)Sanjeev Chawla (771773)Puneet Bagga (4055866)Michael P. Frenneaux (9538623)Ravinder Reddy (564813)Khalid Fakhro (3441305)Mohammad Haris (564809)Clinical sciencesNeurosciencesCellular and Molecular NeurosciencePsychiatry and Mental healthMolecular Biology<p>Autism spectrum disorder (ASD) is a neurodevelopmental impairment characterized by deficits in social interaction skills, impaired communication, and repetitive and restricted behaviors that are thought to be due to altered neurotransmission processes. The amino acid glutamate is an essential excitatory neurotransmitter in the human brain that regulates cognitive functions such as learning and memory, which are usually impaired in ASD. Over the last several years, increasing evidence from genetics, neuroimaging, protein expression, and animal model studies supporting the notion of altered glutamate metabolism has heightened the interest in evaluating glutamatergic dysfunction in ASD. Numerous pharmacological, behavioral, and imaging studies have demonstrated the imbalance in excitatory and inhibitory neurotransmitters, thus revealing the involvement of the glutamatergic system in ASD pathology. Here, we review the effects of genetic alterations on glutamate and its receptors in ASD and the role of non-invasive imaging modalities in detecting these changes. We also highlight the potential therapeutic targets associated with impaired glutamatergic pathways.</p><h2>Other Information</h2> <p> Published in: Molecular Psychiatry<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1038/s41380-022-01506-w" target="_blank">http://dx.doi.org/10.1038/s41380-022-01506-w</a></p>2022-11-22T21:16:36ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1038/s41380-022-01506-whttps://figshare.com/articles/journal_contribution/Genetics_of_glutamate_and_its_receptors_in_autism_spectrum_disorder/21598038CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/215980382022-11-22T21:16:36Z |
| spellingShingle | Genetics of glutamate and its receptors in autism spectrum disorder Sabah Nisar (12561961) Clinical sciences Neurosciences Cellular and Molecular Neuroscience Psychiatry and Mental health Molecular Biology |
| status_str | publishedVersion |
| title | Genetics of glutamate and its receptors in autism spectrum disorder |
| title_full | Genetics of glutamate and its receptors in autism spectrum disorder |
| title_fullStr | Genetics of glutamate and its receptors in autism spectrum disorder |
| title_full_unstemmed | Genetics of glutamate and its receptors in autism spectrum disorder |
| title_short | Genetics of glutamate and its receptors in autism spectrum disorder |
| title_sort | Genetics of glutamate and its receptors in autism spectrum disorder |
| topic | Clinical sciences Neurosciences Cellular and Molecular Neuroscience Psychiatry and Mental health Molecular Biology |