SLFN11 captures cancer-immunity interactions associated with platinum sensitivity in high-grade serous ovarian cancer

SLFN11 captures cancer-immunity interactions associated with platinum sensitivity in high-grade serous ovarian cancer

<p dir="ltr">Large independent analyses on cancer cell lines followed by functional studies have identified Schlafen 11 (SLFN11), a putative helicase, as the strongest predictor of sensitivity to DNA-damaging agents (DDAs), including platinum. However, its role as a prognostic biomar...

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Bibliographic Details
Main Author: Claudia Winkler (436853) (author)
Other Authors: Matthew King (782718) (author), Julie Berthe (18595747) (author), Domenico Ferraioli (15006216) (author), Anna Garuti (212195) (author), Federica Grillo (5306969) (author), Jaime Rodriguez-Canales (436827) (author), Lorenzo Ferrando (6648539) (author), Nicolas Chopin (6114131) (author), Isabelle Ray-Coquard (346757) (author), Oona Delpuech (423602) (author), Davide Bedognetti (2632474) (author), Alberto Ballestrero (212236) (author), Elisabetta Leo (16336) (author), Gabriele Zoppoli (201733) (author)
Published: 2021
Subjects:
Biomedical and clinical sciences
Immunology
Oncology and carcinogenesis
Platinum-based chemotherapy
Prognostic biomarker
Human cancer samples
High-grade serous ovarian carcinoma (HGSOC)
Neoplastic components
Microenvironment
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