Selective induction of apoptosis in T-cell acute lymphoblastic leukemia by pristimerin through dual PI3K/AKT pathway inhibition and ROS generation

<p>T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy characterized by the aberrant activation of survival pathways, particularly the PI3K/AKT axis. Pristimerin (Prist), a naturally occurring quinonemethide triterpenoid, has recently gained attention for its...

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Bibliographic Details
Main Author:	Shilpa Kuttikrishnan (3520079) (author)
Other Authors:	Zahwa Mariyam (22504034) (author), Fareed Ahmad (134672) (author), Mohammad Suleman (22927387) (author), Ummu Habeeba (22504037) (author), Anu J. Panicker (22927390) (author), Kirti S. Prabhu (4246144) (author), Maysaloun Merhi (4246147) (author), Said Dermime (79420) (author), Ammira S. Al Shabeeb Akil (22155844) (author), Ajaz A. Bhat (12984701) (author), Abdul W. Ansari (14557391) (author), Shahab Uddin (154400) (author)
Published:	2025
Subjects:	Biomedical and clinical sciences Immunology Oncology and carcinogenesis Pharmacology and pharmaceutical sciences PristimerinT-cell acute lymphoblastic leukemia PI3K/AKT signaling pathway Apoptosis Cell cycle arrest Molecular docking
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Selective induction of apoptosis in T-cell acute lymphoblastic leukemia by pristimerin through dual PI3K/AKT pathway inhibition and ROS generation

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