Coevolving residues distant from the ligand binding site are involved in GAF domain function

Coevolving residues distant from the ligand binding site are involved in GAF domain function

<p dir="ltr">Ligand binding to GAF domains regulates the activity of associated catalytic domains in various proteins, such as the cGMP-hydrolyzing catalytic domain of phosphodiesterase 5 (PDE5) activated by cGMP binding to GAFa domain. However, the specific residues involved and the...

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Bibliographic Details
Main Author: Wesam S. Ahmed (10170053) (author)
Other Authors: Anupriya M. Geethakumari (17052375) (author), Asfia Sultana (19170880) (author), Anmol Tiwari (22393294) (author), Tausif Altamash (3846304) (author), Najla Arshad (19438042) (author), Sandhya S. Visweswariah (10736916) (author), Kabir H. Biswas (5705864) (author)
Published: 2025
Subjects:
Biological sciences
Plant biology
Biomedical and clinical sciences
Pharmacology and pharmaceutical sciences
GAF domain
Allostery
Phosphodiesterase 5 (PDE5)
cGMP binding
Coevolving residues
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