Lack of Middle East Respiratory Syndrome Coronavirus Transmission in Rabbits
<p dir="ltr">Middle East respiratory syndrome coronavirus (MERS-CoV) transmission from dromedaries to humans has resulted in major outbreaks in the Middle East. Although some other livestock animal species have been shown to be susceptible to MERS-CoV, it is not fully understood why...
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2019
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| _version_ | 1864513525989244928 |
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| author | W. Widagdo (18068932) |
| author2 | Nisreen M. A. Okba (7849805) Mathilde Richard (168469) Dennis de Meulder (14774383) Theo M. Bestebroer (7538081) Pascal Lexmond (74807) Elmoubasher A. B. A. Farag (18068935) Mohammed Al-Hajri (18068938) Koert J. Stittelaar (9287795) Leon de Waal (144348) Geert van Amerongen (81939) Judith M. A. van den Brand (7538069) Bart L. Haagmans (7849811) Sander Herfst (327462) |
| author2_role | author author author author author author author author author author author author author |
| author_facet | W. Widagdo (18068932) Nisreen M. A. Okba (7849805) Mathilde Richard (168469) Dennis de Meulder (14774383) Theo M. Bestebroer (7538081) Pascal Lexmond (74807) Elmoubasher A. B. A. Farag (18068935) Mohammed Al-Hajri (18068938) Koert J. Stittelaar (9287795) Leon de Waal (144348) Geert van Amerongen (81939) Judith M. A. van den Brand (7538069) Bart L. Haagmans (7849811) Sander Herfst (327462) |
| author_role | author |
| dc.creator.none.fl_str_mv | W. Widagdo (18068932) Nisreen M. A. Okba (7849805) Mathilde Richard (168469) Dennis de Meulder (14774383) Theo M. Bestebroer (7538081) Pascal Lexmond (74807) Elmoubasher A. B. A. Farag (18068935) Mohammed Al-Hajri (18068938) Koert J. Stittelaar (9287795) Leon de Waal (144348) Geert van Amerongen (81939) Judith M. A. van den Brand (7538069) Bart L. Haagmans (7849811) Sander Herfst (327462) |
| dc.date.none.fl_str_mv | 2019-04-24T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/v11040381 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Lack_of_Middle_East_Respiratory_Syndrome_Coronavirus_Transmission_in_Rabbits/25303786 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Microbiology Biomedical and clinical sciences Cardiovascular medicine and haematology Medical microbiology Health sciences Epidemiology MERS-coronavirus transmission rabbits |
| dc.title.none.fl_str_mv | Lack of Middle East Respiratory Syndrome Coronavirus Transmission in Rabbits |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Middle East respiratory syndrome coronavirus (MERS-CoV) transmission from dromedaries to humans has resulted in major outbreaks in the Middle East. Although some other livestock animal species have been shown to be susceptible to MERS-CoV, it is not fully understood why the spread of the virus in these animal species has not been observed in the field. In this study, we used rabbits to further characterize the transmission potential of MERS-CoV. In line with the presence of MERS-CoV receptor in the rabbit nasal epithelium, high levels of viral RNA were shed from the nose following virus inoculation. However, unlike MERS-CoV-infected dromedaries, these rabbits did not develop clinical manifestations including nasal discharge and did shed only limited amounts of infectious virus from the nose. Consistently, no transmission by contact or airborne routes was observed in rabbits. Our data indicate that despite relatively high viral RNA levels produced, low levels of infectious virus are excreted in the upper respiratory tract of rabbits as compared to dromedary camels, thus resulting in a lack of viral transmission.</p><h2>Other Information</h2><p dir="ltr">Published in: Viruses<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/v11040381" target="_blank">https://dx.doi.org/10.3390/v11040381</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_03f320261f114db80394f5fc69829a35 |
| identifier_str_mv | 10.3390/v11040381 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25303786 |
| publishDate | 2019 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Lack of Middle East Respiratory Syndrome Coronavirus Transmission in RabbitsW. Widagdo (18068932)Nisreen M. A. Okba (7849805)Mathilde Richard (168469)Dennis de Meulder (14774383)Theo M. Bestebroer (7538081)Pascal Lexmond (74807)Elmoubasher A. B. A. Farag (18068935)Mohammed Al-Hajri (18068938)Koert J. Stittelaar (9287795)Leon de Waal (144348)Geert van Amerongen (81939)Judith M. A. van den Brand (7538069)Bart L. Haagmans (7849811)Sander Herfst (327462)Biological sciencesMicrobiologyBiomedical and clinical sciencesCardiovascular medicine and haematologyMedical microbiologyHealth sciencesEpidemiologyMERS-coronavirustransmissionrabbits<p dir="ltr">Middle East respiratory syndrome coronavirus (MERS-CoV) transmission from dromedaries to humans has resulted in major outbreaks in the Middle East. Although some other livestock animal species have been shown to be susceptible to MERS-CoV, it is not fully understood why the spread of the virus in these animal species has not been observed in the field. In this study, we used rabbits to further characterize the transmission potential of MERS-CoV. In line with the presence of MERS-CoV receptor in the rabbit nasal epithelium, high levels of viral RNA were shed from the nose following virus inoculation. However, unlike MERS-CoV-infected dromedaries, these rabbits did not develop clinical manifestations including nasal discharge and did shed only limited amounts of infectious virus from the nose. Consistently, no transmission by contact or airborne routes was observed in rabbits. Our data indicate that despite relatively high viral RNA levels produced, low levels of infectious virus are excreted in the upper respiratory tract of rabbits as compared to dromedary camels, thus resulting in a lack of viral transmission.</p><h2>Other Information</h2><p dir="ltr">Published in: Viruses<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/v11040381" target="_blank">https://dx.doi.org/10.3390/v11040381</a></p>2019-04-24T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/v11040381https://figshare.com/articles/journal_contribution/Lack_of_Middle_East_Respiratory_Syndrome_Coronavirus_Transmission_in_Rabbits/25303786CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/253037862019-04-24T03:00:00Z |
| spellingShingle | Lack of Middle East Respiratory Syndrome Coronavirus Transmission in Rabbits W. Widagdo (18068932) Biological sciences Microbiology Biomedical and clinical sciences Cardiovascular medicine and haematology Medical microbiology Health sciences Epidemiology MERS-coronavirus transmission rabbits |
| status_str | publishedVersion |
| title | Lack of Middle East Respiratory Syndrome Coronavirus Transmission in Rabbits |
| title_full | Lack of Middle East Respiratory Syndrome Coronavirus Transmission in Rabbits |
| title_fullStr | Lack of Middle East Respiratory Syndrome Coronavirus Transmission in Rabbits |
| title_full_unstemmed | Lack of Middle East Respiratory Syndrome Coronavirus Transmission in Rabbits |
| title_short | Lack of Middle East Respiratory Syndrome Coronavirus Transmission in Rabbits |
| title_sort | Lack of Middle East Respiratory Syndrome Coronavirus Transmission in Rabbits |
| topic | Biological sciences Microbiology Biomedical and clinical sciences Cardiovascular medicine and haematology Medical microbiology Health sciences Epidemiology MERS-coronavirus transmission rabbits |