Generation of induced pluripotent stem cell lines from nonaffected parents and monozygotic triplets affected with autism spectrum disorder and epilepsy
<p dir="ltr">We have generated induced pluripotent stem cell (iPSC) lines from monozygotic triplets with a rare homozygous mutation in NAPB gene (c.354+2T>G). iPSC lines were also generated from their consanguineous parents who were both heterozygous for the inherited NAPB mutatio...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , |
| منشور في: |
2022
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| الموضوعات: | |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513538522873856 |
|---|---|
| author | Gowher Ali (14152593) |
| author2 | Wesal Habbab (17346961) Ghaneya Alkhadairi (17346964) Fouad A. Al-Shaban (15431077) Lawrence W. Stanton (6707191) |
| author2_role | author author author author |
| author_facet | Gowher Ali (14152593) Wesal Habbab (17346961) Ghaneya Alkhadairi (17346964) Fouad A. Al-Shaban (15431077) Lawrence W. Stanton (6707191) |
| author_role | author |
| dc.creator.none.fl_str_mv | Gowher Ali (14152593) Wesal Habbab (17346961) Ghaneya Alkhadairi (17346964) Fouad A. Al-Shaban (15431077) Lawrence W. Stanton (6707191) |
| dc.date.none.fl_str_mv | 2022-12-01T21:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.scr.2022.102943 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Generation_of_induced_pluripotent_stem_cell_lines_from_nonaffected_parents_and_monozygotic_triplets_affected_with_autism_spectrum_disorder_and_epilepsy/24516514 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Medical biotechnology Neurosciences Generation stem cell nonaffected parents monozygotic triplets |
| dc.title.none.fl_str_mv | Generation of induced pluripotent stem cell lines from nonaffected parents and monozygotic triplets affected with autism spectrum disorder and epilepsy |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">We have generated induced pluripotent stem cell (iPSC) lines from monozygotic triplets with a rare homozygous mutation in NAPB gene (c.354+2T>G). iPSC lines were also generated from their consanguineous parents who were both heterozygous for the inherited NAPB mutation. The iPSC lines were generated using non-integrating Sendai viral vectors. All iPSC lines showed prototypical stem cell morphology, expressed pluripotency markers and were able to differentiate to all three germ lineages. These iPSC lines will be useful to explore the molecular function of NAPB in neurophysiology and how its dysfunction potentially contributes to the progression of neurodevelopmental disorders associated with autism and epilepsy.</p><h2>Other Information</h2><p dir="ltr">Published in: Stem Cell Research<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.scr.2022.102943" target="_blank">https://dx.doi.org/10.1016/j.scr.2022.102943</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_03f9dceff2d9fbb2802c2a1695828fa0 |
| identifier_str_mv | 10.1016/j.scr.2022.102943 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24516514 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Generation of induced pluripotent stem cell lines from nonaffected parents and monozygotic triplets affected with autism spectrum disorder and epilepsyGowher Ali (14152593)Wesal Habbab (17346961)Ghaneya Alkhadairi (17346964)Fouad A. Al-Shaban (15431077)Lawrence W. Stanton (6707191)Biological sciencesBiochemistry and cell biologyBiomedical and clinical sciencesMedical biotechnologyNeurosciencesGenerationstem cellnonaffected parentsmonozygotic triplets<p dir="ltr">We have generated induced pluripotent stem cell (iPSC) lines from monozygotic triplets with a rare homozygous mutation in NAPB gene (c.354+2T>G). iPSC lines were also generated from their consanguineous parents who were both heterozygous for the inherited NAPB mutation. The iPSC lines were generated using non-integrating Sendai viral vectors. All iPSC lines showed prototypical stem cell morphology, expressed pluripotency markers and were able to differentiate to all three germ lineages. These iPSC lines will be useful to explore the molecular function of NAPB in neurophysiology and how its dysfunction potentially contributes to the progression of neurodevelopmental disorders associated with autism and epilepsy.</p><h2>Other Information</h2><p dir="ltr">Published in: Stem Cell Research<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.scr.2022.102943" target="_blank">https://dx.doi.org/10.1016/j.scr.2022.102943</a></p>2022-12-01T21:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.scr.2022.102943https://figshare.com/articles/journal_contribution/Generation_of_induced_pluripotent_stem_cell_lines_from_nonaffected_parents_and_monozygotic_triplets_affected_with_autism_spectrum_disorder_and_epilepsy/24516514CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/245165142022-12-01T21:00:00Z |
| spellingShingle | Generation of induced pluripotent stem cell lines from nonaffected parents and monozygotic triplets affected with autism spectrum disorder and epilepsy Gowher Ali (14152593) Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Medical biotechnology Neurosciences Generation stem cell nonaffected parents monozygotic triplets |
| status_str | publishedVersion |
| title | Generation of induced pluripotent stem cell lines from nonaffected parents and monozygotic triplets affected with autism spectrum disorder and epilepsy |
| title_full | Generation of induced pluripotent stem cell lines from nonaffected parents and monozygotic triplets affected with autism spectrum disorder and epilepsy |
| title_fullStr | Generation of induced pluripotent stem cell lines from nonaffected parents and monozygotic triplets affected with autism spectrum disorder and epilepsy |
| title_full_unstemmed | Generation of induced pluripotent stem cell lines from nonaffected parents and monozygotic triplets affected with autism spectrum disorder and epilepsy |
| title_short | Generation of induced pluripotent stem cell lines from nonaffected parents and monozygotic triplets affected with autism spectrum disorder and epilepsy |
| title_sort | Generation of induced pluripotent stem cell lines from nonaffected parents and monozygotic triplets affected with autism spectrum disorder and epilepsy |
| topic | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Medical biotechnology Neurosciences Generation stem cell nonaffected parents monozygotic triplets |