Skull base plasmacytoma in young patients aged below 40 years: Radiological perspectives and clinical outcomes
<h3>Background</h3><p dir="ltr">Plasmacytoma of the skull base is a rare manifestation of plasma cell neoplasm with only a few cases documented in literature involving young adults. Plasmacytoma can be an isolated solitary lesion or a secondary manifestation of multiple m...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , , , , |
| منشور في: |
2024
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| _version_ | 1864513542601834496 |
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| author | Hesham Elsabah (8984069) |
| author2 | Rola Ghasoub (16555851) Dina S. Soliman (14779333) Feryal Ibrahim (14150415) Mahmood B. Aldapt (11255863) Ruba Y. Taha (19206124) Safaa Al Azawi (21842084) Deena Mudawi (16441978) Abbas Moustafa (750768) Halima Elomri (21842087) Honar Cherif (17746722) |
| author2_role | author author author author author author author author author author |
| author_facet | Hesham Elsabah (8984069) Rola Ghasoub (16555851) Dina S. Soliman (14779333) Feryal Ibrahim (14150415) Mahmood B. Aldapt (11255863) Ruba Y. Taha (19206124) Safaa Al Azawi (21842084) Deena Mudawi (16441978) Abbas Moustafa (750768) Halima Elomri (21842087) Honar Cherif (17746722) |
| author_role | author |
| dc.creator.none.fl_str_mv | Hesham Elsabah (8984069) Rola Ghasoub (16555851) Dina S. Soliman (14779333) Feryal Ibrahim (14150415) Mahmood B. Aldapt (11255863) Ruba Y. Taha (19206124) Safaa Al Azawi (21842084) Deena Mudawi (16441978) Abbas Moustafa (750768) Halima Elomri (21842087) Honar Cherif (17746722) |
| dc.date.none.fl_str_mv | 2024-07-05T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1002/cnr2.2106 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Skull_base_plasmacytoma_in_young_patients_aged_below_40_years_Radiological_perspectives_and_clinical_outcomes/29715587 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Neurosciences Oncology and carcinogenesis autologous stem cell transplant clivus multiple myeloma plasmacytoma radiotherapy skull base |
| dc.title.none.fl_str_mv | Skull base plasmacytoma in young patients aged below 40 years: Radiological perspectives and clinical outcomes |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">Plasmacytoma of the skull base is a rare manifestation of plasma cell neoplasm with only a few cases documented in literature involving young adults. Plasmacytoma can be an isolated solitary lesion or a secondary manifestation of multiple myeloma (MM). In this study, we report the clinical and radiological characteristics, management, and outcomes of patients under the age of 40 who presented with skull base plasmacytoma and associated neurological manifestations. Additionally, we share our experience in treating a rare case of skull base plasmacytoma diagnosed during pregnancy, in which the patient exhibited a favorable response to myeloma treatment initiated after delivery.</p><h3>Case Series</h3><p dir="ltr">Four patients were identified, comprising one pregnant female and three male patients, with a median age of 36 years (range 33–37 years). The main presenting symptoms were headache, dizziness, and cranial nerve palsy. All patients received underwent systemic myeloma therapy and radiotherapy with three patients also underwent autologous stem cell transplantation (ASCT). Notably, all patients achieved complete remission.</p><h3>Conclusion</h3><p dir="ltr">Skull base plasmacytoma represents a rare manifestation of plasma cell neoplasms, underscoring the importance of considering it in the differential diagnosis of skull base lesions to ensure early intervention and avoid potential serious complications. Throughout our series, the cornerstone of therapy involved radiotherapy, systemic myeloma therapy, and ASCT, all of which elicited a favorable response in every case.</p><h2>Other Information</h2><p dir="ltr">Published in: Cancer Reports<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/cnr2.2106" target="_blank">https://dx.doi.org/10.1002/cnr2.2106</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_051551c34a2eb2f60697b366bab652c2 |
| identifier_str_mv | 10.1002/cnr2.2106 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/29715587 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Skull base plasmacytoma in young patients aged below 40 years: Radiological perspectives and clinical outcomesHesham Elsabah (8984069)Rola Ghasoub (16555851)Dina S. Soliman (14779333)Feryal Ibrahim (14150415)Mahmood B. Aldapt (11255863)Ruba Y. Taha (19206124)Safaa Al Azawi (21842084)Deena Mudawi (16441978)Abbas Moustafa (750768)Halima Elomri (21842087)Honar Cherif (17746722)Biomedical and clinical sciencesCardiovascular medicine and haematologyNeurosciencesOncology and carcinogenesisautologous stem cell transplantclivusmultiple myelomaplasmacytomaradiotherapyskull base<h3>Background</h3><p dir="ltr">Plasmacytoma of the skull base is a rare manifestation of plasma cell neoplasm with only a few cases documented in literature involving young adults. Plasmacytoma can be an isolated solitary lesion or a secondary manifestation of multiple myeloma (MM). In this study, we report the clinical and radiological characteristics, management, and outcomes of patients under the age of 40 who presented with skull base plasmacytoma and associated neurological manifestations. Additionally, we share our experience in treating a rare case of skull base plasmacytoma diagnosed during pregnancy, in which the patient exhibited a favorable response to myeloma treatment initiated after delivery.</p><h3>Case Series</h3><p dir="ltr">Four patients were identified, comprising one pregnant female and three male patients, with a median age of 36 years (range 33–37 years). The main presenting symptoms were headache, dizziness, and cranial nerve palsy. All patients received underwent systemic myeloma therapy and radiotherapy with three patients also underwent autologous stem cell transplantation (ASCT). Notably, all patients achieved complete remission.</p><h3>Conclusion</h3><p dir="ltr">Skull base plasmacytoma represents a rare manifestation of plasma cell neoplasms, underscoring the importance of considering it in the differential diagnosis of skull base lesions to ensure early intervention and avoid potential serious complications. Throughout our series, the cornerstone of therapy involved radiotherapy, systemic myeloma therapy, and ASCT, all of which elicited a favorable response in every case.</p><h2>Other Information</h2><p dir="ltr">Published in: Cancer Reports<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/cnr2.2106" target="_blank">https://dx.doi.org/10.1002/cnr2.2106</a></p>2024-07-05T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1002/cnr2.2106https://figshare.com/articles/journal_contribution/Skull_base_plasmacytoma_in_young_patients_aged_below_40_years_Radiological_perspectives_and_clinical_outcomes/29715587CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/297155872024-07-05T03:00:00Z |
| spellingShingle | Skull base plasmacytoma in young patients aged below 40 years: Radiological perspectives and clinical outcomes Hesham Elsabah (8984069) Biomedical and clinical sciences Cardiovascular medicine and haematology Neurosciences Oncology and carcinogenesis autologous stem cell transplant clivus multiple myeloma plasmacytoma radiotherapy skull base |
| status_str | publishedVersion |
| title | Skull base plasmacytoma in young patients aged below 40 years: Radiological perspectives and clinical outcomes |
| title_full | Skull base plasmacytoma in young patients aged below 40 years: Radiological perspectives and clinical outcomes |
| title_fullStr | Skull base plasmacytoma in young patients aged below 40 years: Radiological perspectives and clinical outcomes |
| title_full_unstemmed | Skull base plasmacytoma in young patients aged below 40 years: Radiological perspectives and clinical outcomes |
| title_short | Skull base plasmacytoma in young patients aged below 40 years: Radiological perspectives and clinical outcomes |
| title_sort | Skull base plasmacytoma in young patients aged below 40 years: Radiological perspectives and clinical outcomes |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Neurosciences Oncology and carcinogenesis autologous stem cell transplant clivus multiple myeloma plasmacytoma radiotherapy skull base |