Cellular uptake and retention of nanoparticles: Insights on particle properties and interaction with cellular components
<p dir="ltr">The utilization of nanomaterials in the biological and medical field is quickly progressing, particularly in areas where traditional diagnostics and treatment approaches have limited success. The success of nanomaterials in medical products such as biomedical implants, w...
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2020
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| _version_ | 1864513558937600000 |
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| author | Robin Augustine (3976964) |
| author2 | Anwarul Hasan (1332066) Rosita Primavera (2886566) Rudilyn Joyce Wilson (17093014) Avnesh S. Thakor (9411204) Bhavesh D. Kevadiya (11667941) |
| author2_role | author author author author author |
| author_facet | Robin Augustine (3976964) Anwarul Hasan (1332066) Rosita Primavera (2886566) Rudilyn Joyce Wilson (17093014) Avnesh S. Thakor (9411204) Bhavesh D. Kevadiya (11667941) |
| author_role | author |
| dc.creator.none.fl_str_mv | Robin Augustine (3976964) Anwarul Hasan (1332066) Rosita Primavera (2886566) Rudilyn Joyce Wilson (17093014) Avnesh S. Thakor (9411204) Bhavesh D. Kevadiya (11667941) |
| dc.date.none.fl_str_mv | 2020-12-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.mtcomm.2020.101692 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Cellular_uptake_and_retention_of_nanoparticles_Insights_on_particle_properties_and_interaction_with_cellular_components/24242581 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Engineering Materials engineering Nanotechnology Cell-nanoparticle interaction nanomaterials mammalian cells size shape charge functional groups |
| dc.title.none.fl_str_mv | Cellular uptake and retention of nanoparticles: Insights on particle properties and interaction with cellular components |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">The utilization of nanomaterials in the biological and medical field is quickly progressing, particularly in areas where traditional diagnostics and treatment approaches have limited success. The success of nanomaterials in medical products such as biomedical implants, wound dressings and drug delivery systems rely upon their effective interaction between the extracellular matrix, cells, and intracellular components. Upon contact with mammalian cells, nanoparticles (NPs) begin to interact with the extracellular matrix, cell membrane, cytoplasmic proteins, nucleus, and other cellular organelles, which result in nanoparticle internalization and subsequent cellular responses. Such responses elicited by the mammalian cells as a result of the cell-nanomaterials interactions, both at the cellular and molecular level, are mainly determined by the morphological, chemical, and surface characteristics of the nanomaterials themselves. This review provides an overview of how such different attributes, such as chemical nature, size, shape, surface charge, topography, stiffness, and functional features of nanomaterials, influence the cell-nanomaterials interactions.</p><h2>Other Information</h2><p dir="ltr">Published in: Materials Today Communications<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.mtcomm.2020.101692" target="_blank">https://dx.doi.org/10.1016/j.mtcomm.2020.101692</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_0521ed65b43525ccbf1af4fd07ad371d |
| identifier_str_mv | 10.1016/j.mtcomm.2020.101692 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24242581 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Cellular uptake and retention of nanoparticles: Insights on particle properties and interaction with cellular componentsRobin Augustine (3976964)Anwarul Hasan (1332066)Rosita Primavera (2886566)Rudilyn Joyce Wilson (17093014)Avnesh S. Thakor (9411204)Bhavesh D. Kevadiya (11667941)EngineeringMaterials engineeringNanotechnologyCell-nanoparticle interactionnanomaterialsmammalian cellssizeshapechargefunctional groups<p dir="ltr">The utilization of nanomaterials in the biological and medical field is quickly progressing, particularly in areas where traditional diagnostics and treatment approaches have limited success. The success of nanomaterials in medical products such as biomedical implants, wound dressings and drug delivery systems rely upon their effective interaction between the extracellular matrix, cells, and intracellular components. Upon contact with mammalian cells, nanoparticles (NPs) begin to interact with the extracellular matrix, cell membrane, cytoplasmic proteins, nucleus, and other cellular organelles, which result in nanoparticle internalization and subsequent cellular responses. Such responses elicited by the mammalian cells as a result of the cell-nanomaterials interactions, both at the cellular and molecular level, are mainly determined by the morphological, chemical, and surface characteristics of the nanomaterials themselves. This review provides an overview of how such different attributes, such as chemical nature, size, shape, surface charge, topography, stiffness, and functional features of nanomaterials, influence the cell-nanomaterials interactions.</p><h2>Other Information</h2><p dir="ltr">Published in: Materials Today Communications<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.mtcomm.2020.101692" target="_blank">https://dx.doi.org/10.1016/j.mtcomm.2020.101692</a></p>2020-12-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.mtcomm.2020.101692https://figshare.com/articles/journal_contribution/Cellular_uptake_and_retention_of_nanoparticles_Insights_on_particle_properties_and_interaction_with_cellular_components/24242581CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/242425812020-12-01T00:00:00Z |
| spellingShingle | Cellular uptake and retention of nanoparticles: Insights on particle properties and interaction with cellular components Robin Augustine (3976964) Engineering Materials engineering Nanotechnology Cell-nanoparticle interaction nanomaterials mammalian cells size shape charge functional groups |
| status_str | publishedVersion |
| title | Cellular uptake and retention of nanoparticles: Insights on particle properties and interaction with cellular components |
| title_full | Cellular uptake and retention of nanoparticles: Insights on particle properties and interaction with cellular components |
| title_fullStr | Cellular uptake and retention of nanoparticles: Insights on particle properties and interaction with cellular components |
| title_full_unstemmed | Cellular uptake and retention of nanoparticles: Insights on particle properties and interaction with cellular components |
| title_short | Cellular uptake and retention of nanoparticles: Insights on particle properties and interaction with cellular components |
| title_sort | Cellular uptake and retention of nanoparticles: Insights on particle properties and interaction with cellular components |
| topic | Engineering Materials engineering Nanotechnology Cell-nanoparticle interaction nanomaterials mammalian cells size shape charge functional groups |