The apoptotic and anti‐proliferative effects of Neosetophomone B in T‐cell acute lymphoblastic leukaemia via PI3K/AKT/mTOR pathway inhibition

The apoptotic and anti‐proliferative effects of Neosetophomone B in T‐cell acute lymphoblastic leukaemia via PI3K/AKT/mTOR pathway inhibition

<p dir="ltr">The phosphatidylinositol 3‐kinase/Protein Kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) signalling pathway is pivotal in various cancers, including T‐cell acute lymphoblastic leukaemia (T‐ALL), a particularly aggressive type of leukaemia. This study investigates...

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Main Author: Shilpa Kuttikrishnan (3520079) (author)
Other Authors: Abdul W. Ansari (14557391) (author), Muhammad Suleman (3829027) (author), Fareed Ahmad (134672) (author), Kirti S. Prabhu (4246144) (author), Tamam El‐Elimat (17714580) (author), Feras Q. Alali (2691907) (author), Ammira S. Al Shabeeb Akil (22155844) (author), Ajaz A. Bhat (12984701) (author), Maysaloun Merhi (4246147) (author), Said Dermime (79420) (author), Martin Steinhoff (5340194) (author), Shahab Uddin (154400) (author)
Published: 2024
Subjects:
Biomedical and clinical sciences
Oncology and carcinogenesis
Pharmacology and pharmaceutical sciences
Molecular docking
Selective cytotoxicity
Natural product
Targeted therapy
CD3+ T cells
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