Cardioprotective effect of Sanguisorba minor against isoprenaline-induced myocardial infarction in rats
<h3>Introduction</h3><p dir="ltr">Oxidative stress is a major instigator of various cardiovascular diseases, including myocardial infarction (MI). Despite available drugs, there is still an increased need to look for alternative therapies or identify new bioactive compoun...
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2023
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| _version_ | 1864513529447448576 |
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| author | Azar Hosseini (33501) |
| author2 | Atieh Ghorbani (17823386) Mohaddeseh Sadat Alavi (17823389) Nima Forouhi (17823392) Arezoo Rajabian (17823395) Samaneh Boroumand-Noughabi (17823398) Amirhossein Sahebkar (1452028) Ali H. Eid (5461829) |
| author2_role | author author author author author author author |
| author_facet | Azar Hosseini (33501) Atieh Ghorbani (17823386) Mohaddeseh Sadat Alavi (17823389) Nima Forouhi (17823392) Arezoo Rajabian (17823395) Samaneh Boroumand-Noughabi (17823398) Amirhossein Sahebkar (1452028) Ali H. Eid (5461829) |
| author_role | author |
| dc.creator.none.fl_str_mv | Azar Hosseini (33501) Atieh Ghorbani (17823386) Mohaddeseh Sadat Alavi (17823389) Nima Forouhi (17823392) Arezoo Rajabian (17823395) Samaneh Boroumand-Noughabi (17823398) Amirhossein Sahebkar (1452028) Ali H. Eid (5461829) |
| dc.date.none.fl_str_mv | 2023-12-21T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3389/fphar.2023.1305816 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Cardioprotective_effect_of_Sanguisorba_minor_against_isoprenaline-induced_myocardial_infarction_in_rats/25038263 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Pharmacology and pharmaceutical sciences myocardial infarction isoprenaline oxidative stress cardiotoxicity herbal medicine superoxide dismutase |
| dc.title.none.fl_str_mv | Cardioprotective effect of Sanguisorba minor against isoprenaline-induced myocardial infarction in rats |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Introduction</h3><p dir="ltr">Oxidative stress is a major instigator of various cardiovascular diseases, including myocardial infarction (MI). Despite available drugs, there is still an increased need to look for alternative therapies or identify new bioactive compounds. Sanguisorba minor (S. minor) is a native herb characterized by its potent antioxidant activity. This study was designed to evaluate the effect of S. minor against isoprenaline-induced MI.</p><h3>Methods</h3><p dir="ltr">Rats were treated with the hydro-ethanolic extract of the aerial parts of S. minor at doses of 100 or 300 mg/kg orally for 9 days. Isoprenaline was injected subcutaneously at the dose of 85 mg/kg on days 8 and 9. Then, the activities of various cardiac injury markers including cardiac troponin (cTnT), lactate dehydrogenase (LDH), creatinine kinase muscle brain (CK-MB), creatinine phosphokinase (CPK), and antioxidant enzymes in serum were determined. Malondialdehyde (MDA) and thiol content were measured in cardiac tissue, and histopathological analysis was conducted.</p><h3>Results</h3><p dir="ltr">Our results show that isoprenaline increased the serum levels of cTnT, LDH, CK-MB, and CPK (p < 0.001) and elevated MDA levels (p < 0.001) in cardiac tissue. Isoprenaline also reduced superoxide dismutase (SOD), catalase, and thiol content (p < 0.001). Importantly, the extract abolished isoprenaline-induced MI by elevating SOD and catalase (p < 0.001), reducing levels of MDA, and diminishing levels of cTnT, LDH, CK-MB, and CPK cardiac markers (p < 0.001). Histopathological studies of the cardiac tissue showed isoprenaline-induced injury that was significantly attenuated by the extract.</p><h3>Conclusion</h3><p dir="ltr">Our results suggest that S. minor could abrogate isoprenaline-induced cardiac toxicity due to its ability to mitigate oxidative stress.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Pharmacology<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fphar.2023.1305816" target="_blank">https://dx.doi.org/10.3389/fphar.2023.1305816</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_063e1dbc3caa2f14eead307aa430a0aa |
| identifier_str_mv | 10.3389/fphar.2023.1305816 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25038263 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Cardioprotective effect of Sanguisorba minor against isoprenaline-induced myocardial infarction in ratsAzar Hosseini (33501)Atieh Ghorbani (17823386)Mohaddeseh Sadat Alavi (17823389)Nima Forouhi (17823392)Arezoo Rajabian (17823395)Samaneh Boroumand-Noughabi (17823398)Amirhossein Sahebkar (1452028)Ali H. Eid (5461829)Biomedical and clinical sciencesCardiovascular medicine and haematologyPharmacology and pharmaceutical sciencesmyocardial infarctionisoprenalineoxidative stresscardiotoxicityherbal medicinesuperoxide dismutase<h3>Introduction</h3><p dir="ltr">Oxidative stress is a major instigator of various cardiovascular diseases, including myocardial infarction (MI). Despite available drugs, there is still an increased need to look for alternative therapies or identify new bioactive compounds. Sanguisorba minor (S. minor) is a native herb characterized by its potent antioxidant activity. This study was designed to evaluate the effect of S. minor against isoprenaline-induced MI.</p><h3>Methods</h3><p dir="ltr">Rats were treated with the hydro-ethanolic extract of the aerial parts of S. minor at doses of 100 or 300 mg/kg orally for 9 days. Isoprenaline was injected subcutaneously at the dose of 85 mg/kg on days 8 and 9. Then, the activities of various cardiac injury markers including cardiac troponin (cTnT), lactate dehydrogenase (LDH), creatinine kinase muscle brain (CK-MB), creatinine phosphokinase (CPK), and antioxidant enzymes in serum were determined. Malondialdehyde (MDA) and thiol content were measured in cardiac tissue, and histopathological analysis was conducted.</p><h3>Results</h3><p dir="ltr">Our results show that isoprenaline increased the serum levels of cTnT, LDH, CK-MB, and CPK (p < 0.001) and elevated MDA levels (p < 0.001) in cardiac tissue. Isoprenaline also reduced superoxide dismutase (SOD), catalase, and thiol content (p < 0.001). Importantly, the extract abolished isoprenaline-induced MI by elevating SOD and catalase (p < 0.001), reducing levels of MDA, and diminishing levels of cTnT, LDH, CK-MB, and CPK cardiac markers (p < 0.001). Histopathological studies of the cardiac tissue showed isoprenaline-induced injury that was significantly attenuated by the extract.</p><h3>Conclusion</h3><p dir="ltr">Our results suggest that S. minor could abrogate isoprenaline-induced cardiac toxicity due to its ability to mitigate oxidative stress.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Pharmacology<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fphar.2023.1305816" target="_blank">https://dx.doi.org/10.3389/fphar.2023.1305816</a></p>2023-12-21T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3389/fphar.2023.1305816https://figshare.com/articles/journal_contribution/Cardioprotective_effect_of_Sanguisorba_minor_against_isoprenaline-induced_myocardial_infarction_in_rats/25038263CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/250382632023-12-21T03:00:00Z |
| spellingShingle | Cardioprotective effect of Sanguisorba minor against isoprenaline-induced myocardial infarction in rats Azar Hosseini (33501) Biomedical and clinical sciences Cardiovascular medicine and haematology Pharmacology and pharmaceutical sciences myocardial infarction isoprenaline oxidative stress cardiotoxicity herbal medicine superoxide dismutase |
| status_str | publishedVersion |
| title | Cardioprotective effect of Sanguisorba minor against isoprenaline-induced myocardial infarction in rats |
| title_full | Cardioprotective effect of Sanguisorba minor against isoprenaline-induced myocardial infarction in rats |
| title_fullStr | Cardioprotective effect of Sanguisorba minor against isoprenaline-induced myocardial infarction in rats |
| title_full_unstemmed | Cardioprotective effect of Sanguisorba minor against isoprenaline-induced myocardial infarction in rats |
| title_short | Cardioprotective effect of Sanguisorba minor against isoprenaline-induced myocardial infarction in rats |
| title_sort | Cardioprotective effect of Sanguisorba minor against isoprenaline-induced myocardial infarction in rats |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Pharmacology and pharmaceutical sciences myocardial infarction isoprenaline oxidative stress cardiotoxicity herbal medicine superoxide dismutase |