Liraglutide for idiopathic intracranial hypertension: a real‐world propensity score‐matched study
<h3>Objective</h3><p dir="ltr">Idiopathic intracranial hypertension (IIH) is a neurological disorder predominantly affecting young women with obesity, characterized by elevated intracranial pressure. While current treatments include weight loss counseling, medical therapi...
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2025
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| _version_ | 1864513538009071616 |
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| author | Ahmed Y. Azzam (14267391) |
| author2 | Muhammed Amir Essibayi (13008835) Dhrumil Vaishnav (22330735) Mohammed A. Azab (12733142) Mahmoud M. Morsy (18560491) Osman Elamin (18560494) Adam Elswedy (18560497) Oday Atallah (18295720) Hana J. Abukhadijah (22045418) Adam A. Dmytriw (9386351) Amanda Baker (2008783) Deepak Khatri (19199878) Neil Haranhalli (22330729) David J. Altschul (9159074) |
| author2_role | author author author author author author author author author author author author author |
| author_facet | Ahmed Y. Azzam (14267391) Muhammed Amir Essibayi (13008835) Dhrumil Vaishnav (22330735) Mohammed A. Azab (12733142) Mahmoud M. Morsy (18560491) Osman Elamin (18560494) Adam Elswedy (18560497) Oday Atallah (18295720) Hana J. Abukhadijah (22045418) Adam A. Dmytriw (9386351) Amanda Baker (2008783) Deepak Khatri (19199878) Neil Haranhalli (22330729) David J. Altschul (9159074) |
| author_role | author |
| dc.creator.none.fl_str_mv | Ahmed Y. Azzam (14267391) Muhammed Amir Essibayi (13008835) Dhrumil Vaishnav (22330735) Mohammed A. Azab (12733142) Mahmoud M. Morsy (18560491) Osman Elamin (18560494) Adam Elswedy (18560497) Oday Atallah (18295720) Hana J. Abukhadijah (22045418) Adam A. Dmytriw (9386351) Amanda Baker (2008783) Deepak Khatri (19199878) Neil Haranhalli (22330729) David J. Altschul (9159074) |
| dc.date.none.fl_str_mv | 2025-02-13T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1002/acn3.52300 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Liraglutide_for_idiopathic_intracranial_hypertension_a_real_world_propensity_score_matched_study/30234376 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Neurosciences Pharmacology and pharmaceutical sciences Intracranial Hypertension Liraglutide Papilledema GLP-1 Receptor Agonist Obesity |
| dc.title.none.fl_str_mv | Liraglutide for idiopathic intracranial hypertension: a real‐world propensity score‐matched study |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Objective</h3><p dir="ltr">Idiopathic intracranial hypertension (IIH) is a neurological disorder predominantly affecting young women with obesity, characterized by elevated intracranial pressure. While current treatments include weight loss counseling, medical therapies, and surgical interventions, their limitations necessitate exploring novel therapeutic approaches. We investigated the efficacy of liraglutide as an adjunctive therapy in IIH management.</p><h3>Methods</h3><p dir="ltr">We conducted a retrospective cohort study, analyzing adult patients with IIH. Through propensity score matching, we compared patients receiving liraglutide alongside standard therapy (<i>n</i> = 204) with those receiving standard therapy alone (<i>n</i> = 204). Primary outcomes included papilledema, headache manifestations, and visual disturbances, assessed at 3, 6, 12, and 24 months posttreatment initiation.</p><h3>Results</h3><p dir="ltr">Our matched cohorts were predominantly female (95.1% vs. 97.1%) with comparable mean ages (37.6 vs. 37.3 years). Liraglutide treatment demonstrated significant reduction in papilledema risk at 3 months (RR 0.333, 95% CI 0.167–0.664, <i>p</i> = 0.001), with sustained benefits throughout 24 months (RR 0.524, 95% CI 0.325–0.845, <i>p</i> = 0.006). While improvements were observed in visual disturbances, headache symptoms, and refractory IIH cases, these did not reach statistical significance.</p><h3>Interpretation</h3><p dir="ltr">Our findings suggest that liraglutide as an adjunctive therapy significantly improves papilledema outcomes in IIH patients, with the greatest effect observed at 3 months and sustained benefits over 2 years. This study provides promising evidence for liraglutide's role in IIH management, particularly in addressing papilledema.</p><h2>Other Information</h2><p dir="ltr">Published in: Annals of Clinical and Translational Neurology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/acn3.52300" target="_blank">https://dx.doi.org/10.1002/acn3.52300</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_067026f27311c676219e577c02db1b1b |
| identifier_str_mv | 10.1002/acn3.52300 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/30234376 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Liraglutide for idiopathic intracranial hypertension: a real‐world propensity score‐matched studyAhmed Y. Azzam (14267391)Muhammed Amir Essibayi (13008835)Dhrumil Vaishnav (22330735)Mohammed A. Azab (12733142)Mahmoud M. Morsy (18560491)Osman Elamin (18560494)Adam Elswedy (18560497)Oday Atallah (18295720)Hana J. Abukhadijah (22045418)Adam A. Dmytriw (9386351)Amanda Baker (2008783)Deepak Khatri (19199878)Neil Haranhalli (22330729)David J. Altschul (9159074)Biomedical and clinical sciencesCardiovascular medicine and haematologyNeurosciencesPharmacology and pharmaceutical sciencesIntracranial HypertensionLiraglutidePapilledemaGLP-1 Receptor AgonistObesity<h3>Objective</h3><p dir="ltr">Idiopathic intracranial hypertension (IIH) is a neurological disorder predominantly affecting young women with obesity, characterized by elevated intracranial pressure. While current treatments include weight loss counseling, medical therapies, and surgical interventions, their limitations necessitate exploring novel therapeutic approaches. We investigated the efficacy of liraglutide as an adjunctive therapy in IIH management.</p><h3>Methods</h3><p dir="ltr">We conducted a retrospective cohort study, analyzing adult patients with IIH. Through propensity score matching, we compared patients receiving liraglutide alongside standard therapy (<i>n</i> = 204) with those receiving standard therapy alone (<i>n</i> = 204). Primary outcomes included papilledema, headache manifestations, and visual disturbances, assessed at 3, 6, 12, and 24 months posttreatment initiation.</p><h3>Results</h3><p dir="ltr">Our matched cohorts were predominantly female (95.1% vs. 97.1%) with comparable mean ages (37.6 vs. 37.3 years). Liraglutide treatment demonstrated significant reduction in papilledema risk at 3 months (RR 0.333, 95% CI 0.167–0.664, <i>p</i> = 0.001), with sustained benefits throughout 24 months (RR 0.524, 95% CI 0.325–0.845, <i>p</i> = 0.006). While improvements were observed in visual disturbances, headache symptoms, and refractory IIH cases, these did not reach statistical significance.</p><h3>Interpretation</h3><p dir="ltr">Our findings suggest that liraglutide as an adjunctive therapy significantly improves papilledema outcomes in IIH patients, with the greatest effect observed at 3 months and sustained benefits over 2 years. This study provides promising evidence for liraglutide's role in IIH management, particularly in addressing papilledema.</p><h2>Other Information</h2><p dir="ltr">Published in: Annals of Clinical and Translational Neurology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/acn3.52300" target="_blank">https://dx.doi.org/10.1002/acn3.52300</a></p>2025-02-13T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1002/acn3.52300https://figshare.com/articles/journal_contribution/Liraglutide_for_idiopathic_intracranial_hypertension_a_real_world_propensity_score_matched_study/30234376CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/302343762025-02-13T09:00:00Z |
| spellingShingle | Liraglutide for idiopathic intracranial hypertension: a real‐world propensity score‐matched study Ahmed Y. Azzam (14267391) Biomedical and clinical sciences Cardiovascular medicine and haematology Neurosciences Pharmacology and pharmaceutical sciences Intracranial Hypertension Liraglutide Papilledema GLP-1 Receptor Agonist Obesity |
| status_str | publishedVersion |
| title | Liraglutide for idiopathic intracranial hypertension: a real‐world propensity score‐matched study |
| title_full | Liraglutide for idiopathic intracranial hypertension: a real‐world propensity score‐matched study |
| title_fullStr | Liraglutide for idiopathic intracranial hypertension: a real‐world propensity score‐matched study |
| title_full_unstemmed | Liraglutide for idiopathic intracranial hypertension: a real‐world propensity score‐matched study |
| title_short | Liraglutide for idiopathic intracranial hypertension: a real‐world propensity score‐matched study |
| title_sort | Liraglutide for idiopathic intracranial hypertension: a real‐world propensity score‐matched study |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Neurosciences Pharmacology and pharmaceutical sciences Intracranial Hypertension Liraglutide Papilledema GLP-1 Receptor Agonist Obesity |