Treatment with a Combination of Metformin and 2-Deoxyglucose Upregulates Thrombospondin-1 in Microvascular Endothelial Cells: Implications in Anti-Angiogenic Cancer Therapy

Treatment with a Combination of Metformin and 2-Deoxyglucose Upregulates Thrombospondin-1 in Microvascular Endothelial Cells: Implications in Anti-Angiogenic Cancer Therapy

<p dir="ltr">Metformin, the most widely used anti-diabetic drug, also exhibits anti-cancer properties; however, the true potential of metformin as an anticancer drug remains largely unknown. In this study using mouse microvascular endothelial cells (MMECs), we investigated the effect...

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Bibliographic Details
Main Author: Samson Mathews Samuel (18808246) (author)
Other Authors: Noothan Jyothi Satheesh (18808249) (author), Suparna Ghosh (9698402) (author), Dietrich Büsselberg (11008857) (author), Yasser Majeed (9417974) (author), Hong Ding (135247) (author), Chris R. Triggle (4278688) (author)
Published: 2019
Subjects:
Biomedical and clinical sciences
Oncology and carcinogenesis
Pharmacology and pharmaceutical sciences
angiogenesis
cancer
combination therapy
metformin
organic cation transporter (OCT)
tumor endothelial cells
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