Hypoxic Stress Induces Complement-Mediated Lysis of Mesenchymal Stem Cells by Downregulating Factor H and CD59

Hypoxic Stress Induces Complement-Mediated Lysis of Mesenchymal Stem Cells by Downregulating Factor H and CD59

<h3>Background</h3><p dir="ltr">Factor H and membrane inhibitor of reactive lysis (CD59) are key regulators of complement activation. Mesenchymal stem cells (MSCs) secrete Factor H and express CD59 to protect themselves from complement-mediated damage. Severe hypoxia foun...

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Bibliographic Details
Main Author: Ramada R. Khaswaneh (22224544) (author)
Other Authors: Ejlal Abu-El-Rub (5168183) (author), Ayman Alzu’bi (13162392) (author), Fatimah A. Almahasneh (22224547) (author), Rawan. A. Almazari (22224304) (author), Heba F. AI-jariri (22224550) (author), Raed M. Al-Zoubi (2037490) (author)
Published: 2024
Subjects:
Biomedical and clinical sciences
Clinical sciences
Immunology
MSCs
Hypoxia
Survival
Factor H
CD59
MAC complex
Apoptosis
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