Synthesis, Bioapplications, and Toxicity Evaluation of Chitosan-Based Nanoparticles
<div><p>The development of advanced nanomaterials and technologies is essential in biomedical engineering to improve the quality of life. Chitosan-based nanomaterials are on the forefront and attract wide interest due to their versatile physicochemical characteristics such as biodegradab...
محفوظ في:
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| مؤلفون آخرون: | , , |
| منشور في: |
2019
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| _version_ | 1864513525411479552 |
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| author | Balsam R. Rizeq (18095371) |
| author2 | Nadin N. Younes (10977237) Kashif Rasool (2542492) Gheyath K. Nasrallah (9200525) |
| author2_role | author author author |
| author_facet | Balsam R. Rizeq (18095371) Nadin N. Younes (10977237) Kashif Rasool (2542492) Gheyath K. Nasrallah (9200525) |
| author_role | author |
| dc.creator.none.fl_str_mv | Balsam R. Rizeq (18095371) Nadin N. Younes (10977237) Kashif Rasool (2542492) Gheyath K. Nasrallah (9200525) |
| dc.date.none.fl_str_mv | 2019-11-16T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/ijms20225776 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Synthesis_Bioapplications_and_Toxicity_Evaluation_of_Chitosan-Based_Nanoparticles/25334539 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Chemical sciences Inorganic chemistry Organic chemistry Physical chemistry Theoretical and computational chemistry Chitosan nanoparticles biomedical pharmaceuticals toxicity |
| dc.title.none.fl_str_mv | Synthesis, Bioapplications, and Toxicity Evaluation of Chitosan-Based Nanoparticles |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <div><p>The development of advanced nanomaterials and technologies is essential in biomedical engineering to improve the quality of life. Chitosan-based nanomaterials are on the forefront and attract wide interest due to their versatile physicochemical characteristics such as biodegradability, biocompatibility, and non-toxicity, which play a promising role in biological applications. Chitosan and its derivatives are employed in several applications including pharmaceuticals and biomedical engineering. This article presents a comprehensive overview of recent advances in chitosan derivatives and nanoparticle synthesis, as well as emerging applications in medicine, tissue engineering, drug delivery, gene therapy, and cancer therapy. In addition to the applications, we critically review the main concerns and mitigation strategies related to chitosan bactericidal properties, toxicity/safety using tissue cultures and animal models, and also their potential environmental impact. At the end of this review, we also provide some of future directions and conclusions that are important for expanding the field of biomedical applications of the chitosan nanoparticles.</p><p> </p></div><h2>Other Information</h2> <p> Published in: International Journal of Molecular Sciences<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/ijms20225776" target="_blank">https://dx.doi.org/10.3390/ijms20225776</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_07e016fd52753dd7b3ec5fe27617146f |
| identifier_str_mv | 10.3390/ijms20225776 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25334539 |
| publishDate | 2019 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Synthesis, Bioapplications, and Toxicity Evaluation of Chitosan-Based NanoparticlesBalsam R. Rizeq (18095371)Nadin N. Younes (10977237)Kashif Rasool (2542492)Gheyath K. Nasrallah (9200525)Chemical sciencesInorganic chemistryOrganic chemistryPhysical chemistryTheoretical and computational chemistryChitosannanoparticlesbiomedicalpharmaceuticalstoxicity<div><p>The development of advanced nanomaterials and technologies is essential in biomedical engineering to improve the quality of life. Chitosan-based nanomaterials are on the forefront and attract wide interest due to their versatile physicochemical characteristics such as biodegradability, biocompatibility, and non-toxicity, which play a promising role in biological applications. Chitosan and its derivatives are employed in several applications including pharmaceuticals and biomedical engineering. This article presents a comprehensive overview of recent advances in chitosan derivatives and nanoparticle synthesis, as well as emerging applications in medicine, tissue engineering, drug delivery, gene therapy, and cancer therapy. In addition to the applications, we critically review the main concerns and mitigation strategies related to chitosan bactericidal properties, toxicity/safety using tissue cultures and animal models, and also their potential environmental impact. At the end of this review, we also provide some of future directions and conclusions that are important for expanding the field of biomedical applications of the chitosan nanoparticles.</p><p> </p></div><h2>Other Information</h2> <p> Published in: International Journal of Molecular Sciences<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/ijms20225776" target="_blank">https://dx.doi.org/10.3390/ijms20225776</a></p>2019-11-16T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/ijms20225776https://figshare.com/articles/journal_contribution/Synthesis_Bioapplications_and_Toxicity_Evaluation_of_Chitosan-Based_Nanoparticles/25334539CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/253345392019-11-16T03:00:00Z |
| spellingShingle | Synthesis, Bioapplications, and Toxicity Evaluation of Chitosan-Based Nanoparticles Balsam R. Rizeq (18095371) Chemical sciences Inorganic chemistry Organic chemistry Physical chemistry Theoretical and computational chemistry Chitosan nanoparticles biomedical pharmaceuticals toxicity |
| status_str | publishedVersion |
| title | Synthesis, Bioapplications, and Toxicity Evaluation of Chitosan-Based Nanoparticles |
| title_full | Synthesis, Bioapplications, and Toxicity Evaluation of Chitosan-Based Nanoparticles |
| title_fullStr | Synthesis, Bioapplications, and Toxicity Evaluation of Chitosan-Based Nanoparticles |
| title_full_unstemmed | Synthesis, Bioapplications, and Toxicity Evaluation of Chitosan-Based Nanoparticles |
| title_short | Synthesis, Bioapplications, and Toxicity Evaluation of Chitosan-Based Nanoparticles |
| title_sort | Synthesis, Bioapplications, and Toxicity Evaluation of Chitosan-Based Nanoparticles |
| topic | Chemical sciences Inorganic chemistry Organic chemistry Physical chemistry Theoretical and computational chemistry Chitosan nanoparticles biomedical pharmaceuticals toxicity |