Vitamin D<sub>3</sub> metabolite ratio as an indicator of vitamin D status and its association with diabetes complications
<h3>Background</h3><p dir="ltr">Vitamin D deficiency is diagnosed by total serum 25-hydroxyvitamin D (25(OH)D) concentration and is associated with poor health and increased mortality; however, some populations have low 25(OH) D concentrations without manifestations of vi...
محفوظ في:
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| مؤلفون آخرون: | , , , , , |
| منشور في: |
2020
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| الوسوم: |
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| الملخص: | <h3>Background</h3><p dir="ltr">Vitamin D deficiency is diagnosed by total serum 25-hydroxyvitamin D (25(OH)D) concentration and is associated with poor health and increased mortality; however, some populations have low 25(OH) D concentrations without manifestations of vitamin D deficiency. The Vitamin D Metabolite Ratio (VMR) has been suggested as a superior indicator of vitamin D status. Therefore, VMR was determined in a population with type 2 diabetes at high risk for vitamin D deficiency and correlated with diabetic complications.</p><h3>Research design and methods</h3><p dir="ltr">Four hundred sisty patients with type 2 diabetes (T2D) were recruited, all were vitamin D3 supplement naive. Plasma concentration of 25-hydroxyvitamin D<sub>3</sub> (25(OH)D<sub>3</sub>) and its metabolites 1,25-dihydroxyvitamin D<sub>3</sub> (1,25(OH)<sub>2</sub>D<sub>3</sub>) and 24,25-dihydroxyvitamin D<sub>3</sub> (24,25(OH)<sub>2</sub>D<sub>3</sub>) and its epimer, 3-epi-25-hydroxyvitamin D<sub>3</sub> (3-epi-25(OH)D<sub>3</sub>), were measured by LC-MS/MS analysis. VMR-1 was calculated as a ratio of 24,25(OH)<sub>2</sub>D<sub>3</sub>:25(OH)D<sub>3</sub>; VMR-2 as a ratio of 1,25(OH)<sub>2</sub>D<sub>3</sub>:25(OH)D<sub>3</sub>; VMR-3 was calculated as a ratio of 3-epi-25(OH)D<sub>3</sub>: 25(OH)D<sub>3</sub>.</p><h3>Results</h3><p dir="ltr">An association means that there were significant differences between the ratios found for those with versus those without the various diabetic complications studied. VMR-<sub>1</sub> was associated with diabetic retinopathy (p = 0.001) and peripheral artery disease (p = 0.012); VMR-<sub>2</sub> associated with hypertension (p < 0.001), dyslipidemia (p < 0.001), diabetic retinopathy (p < 0.001), diabetic neuropathy (p < 0.001), coronary artery disease (p = 0.001) and stroke (p < 0.05). VMR-<sub>3</sub> associated with hypertension (p < 0.05), dyslipidemia (p < 0.001) and coronary artery disease (p < 0.05).</p><h3>Conclusions</h3><p dir="ltr">In this cross sectional study, whilst not causal, VMR-<sub>2</sub> was shown to be the superior predictor of diabetic and cardiovascular complications though not demonstrative of causality in this cross-sectional study population over VMR-<sub>1</sub>, VMR-<sub>3</sub> and the individual vitamin D concentration measurements; VMR-<sub>2</sub> associated with both microvascular and cardiovascular indices and therefore may have utility in predicting the development of diabetic complications.</p><h2>Other Information</h2><p dir="ltr">Published in: BMC Endocrine Disorders<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s12902-020-00641-1" target="_blank">https://dx.doi.org/10.1186/s12902-020-00641-1</a></p> |
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