Integrative Ligand-Based Pharmacophore Modeling, Virtual Screening, and Molecular Docking Simulation Approaches Identified Potential Lead Compounds against Pancreatic Cancer by Targeting FAK1

Integrative Ligand-Based Pharmacophore Modeling, Virtual Screening, and Molecular Docking Simulation Approaches Identified Potential Lead Compounds against Pancreatic Cancer by Targeting FAK1

<p dir="ltr">Pancreatic cancer is a very deadly disease with a 5-year survival rate, making it one of the leading causes of cancer-related deaths globally. Focal adhesion kinase 1 (FAK1) is a ubiquitously expressed protein in pancreatic cancer. FAK, a tyrosine kinase that is overexpr...

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Bibliographic Details
Main Author: Mohammad Molla (19467889) (author)
Other Authors: Mohammed Aljahdali (19467892) (author), Md Sumon (19467895) (author), Amer Asseri (19467898) (author), Hisham Altayb (16299020) (author), Md. Islam (3413852) (author), Ahad Alsaiari (19467901) (author), F. Opo (19467904) (author), Nushrat Jahan (19467907) (author), Foysal Ahammad (9286524) (author), Farhan Mohammad (256409) (author)
Published: 2023
Subjects:
Biomedical and clinical sciences
Clinical sciences
Oncology and carcinogenesis
Pharmacology and pharmaceutical sciences
pancreatic cancer
FAK1 protein
ligand-based pharmacophore drug design
purchasable compounds
molecular docking
ADMET
MD simulation
MM-GBSA
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