Metabolic signature of obesity-associated insulin resistance and type 2 diabetes
<h3>Background</h3><p dir="ltr">Obesity is associated with an increased risk of insulin resistance and type 2 diabetes mellitus (T2DM). However, some obese individuals maintain their insulin sensitivity and exhibit a lower risk of associated comorbidities. The underlying...
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| مؤلفون آخرون: | , , , , , , |
| منشور في: |
2019
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| _version_ | 1864513515125997568 |
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| author | Haya Al-Sulaiti (5449256) |
| author2 | Ilhame Diboun (3522413) Maha V. Agha (7956170) Fatima F. S. Mohamed (18602959) Stephen Atkin (5169707) Alex S. Dömling (7956176) Mohamed A. Elrayess (7956179) Nayef A. Mazloum (7355087) |
| author2_role | author author author author author author author |
| author_facet | Haya Al-Sulaiti (5449256) Ilhame Diboun (3522413) Maha V. Agha (7956170) Fatima F. S. Mohamed (18602959) Stephen Atkin (5169707) Alex S. Dömling (7956176) Mohamed A. Elrayess (7956179) Nayef A. Mazloum (7355087) |
| author_role | author |
| dc.creator.none.fl_str_mv | Haya Al-Sulaiti (5449256) Ilhame Diboun (3522413) Maha V. Agha (7956170) Fatima F. S. Mohamed (18602959) Stephen Atkin (5169707) Alex S. Dömling (7956176) Mohamed A. Elrayess (7956179) Nayef A. Mazloum (7355087) |
| dc.date.none.fl_str_mv | 2019-10-22T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1186/s12967-019-2096-8 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Metabolic_signature_of_obesity-associated_insulin_resistance_and_type_2_diabetes/25886941 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Medical biochemistry and metabolomics Metabolomics Blood metabolites Insulin sensitivity Insulin resistance Type 2 diabetes mellitus |
| dc.title.none.fl_str_mv | Metabolic signature of obesity-associated insulin resistance and type 2 diabetes |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">Obesity is associated with an increased risk of insulin resistance and type 2 diabetes mellitus (T2DM). However, some obese individuals maintain their insulin sensitivity and exhibit a lower risk of associated comorbidities. The underlying metabolic pathways differentiating obese insulin sensitive (OIS) and obese insulin resistant (OIR) individuals remain unclear.</p><h3>Methods</h3><p dir="ltr">In this study, 107 subjects underwent untargeted metabolomics of serum samples using the Metabolon platform. Thirty-two subjects were lean controls whilst 75 subjects were obese including 20 OIS, 41 OIR, and 14 T2DM individuals.</p><h3>Results</h3><p dir="ltr">Our results showed that phospholipid metabolites including choline, glycerophosphoethanolamine and glycerophosphorylcholine were significantly altered from OIS when compared with OIR and T2DM individuals. Furthermore, our data confirmed changes in metabolic markers of liver disease, vascular disease and T2DM, such as 3-hydroxymyristate, dimethylarginine and 1,5-anhydroglucitol, respectively.</p><h3>Conclusion</h3><p dir="ltr">This pilot data has identified phospholipid metabolites as potential novel biomarkers of obesity-associated insulin sensitivity and confirmed the association of known metabolites with increased risk of obesity-associated insulin resistance, with possible diagnostic and therapeutic applications. Further studies are warranted to confirm these associations in prospective cohorts and to investigate their functionality.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Translational Medicine<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s12967-019-2096-8" target="_blank">https://dx.doi.org/10.1186/s12967-019-2096-8</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_099e9e81cc239ec4092234dbe7d039d1 |
| identifier_str_mv | 10.1186/s12967-019-2096-8 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25886941 |
| publishDate | 2019 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Metabolic signature of obesity-associated insulin resistance and type 2 diabetesHaya Al-Sulaiti (5449256)Ilhame Diboun (3522413)Maha V. Agha (7956170)Fatima F. S. Mohamed (18602959)Stephen Atkin (5169707)Alex S. Dömling (7956176)Mohamed A. Elrayess (7956179)Nayef A. Mazloum (7355087)Biomedical and clinical sciencesMedical biochemistry and metabolomicsMetabolomicsBlood metabolitesInsulin sensitivityInsulin resistanceType 2 diabetes mellitus<h3>Background</h3><p dir="ltr">Obesity is associated with an increased risk of insulin resistance and type 2 diabetes mellitus (T2DM). However, some obese individuals maintain their insulin sensitivity and exhibit a lower risk of associated comorbidities. The underlying metabolic pathways differentiating obese insulin sensitive (OIS) and obese insulin resistant (OIR) individuals remain unclear.</p><h3>Methods</h3><p dir="ltr">In this study, 107 subjects underwent untargeted metabolomics of serum samples using the Metabolon platform. Thirty-two subjects were lean controls whilst 75 subjects were obese including 20 OIS, 41 OIR, and 14 T2DM individuals.</p><h3>Results</h3><p dir="ltr">Our results showed that phospholipid metabolites including choline, glycerophosphoethanolamine and glycerophosphorylcholine were significantly altered from OIS when compared with OIR and T2DM individuals. Furthermore, our data confirmed changes in metabolic markers of liver disease, vascular disease and T2DM, such as 3-hydroxymyristate, dimethylarginine and 1,5-anhydroglucitol, respectively.</p><h3>Conclusion</h3><p dir="ltr">This pilot data has identified phospholipid metabolites as potential novel biomarkers of obesity-associated insulin sensitivity and confirmed the association of known metabolites with increased risk of obesity-associated insulin resistance, with possible diagnostic and therapeutic applications. Further studies are warranted to confirm these associations in prospective cohorts and to investigate their functionality.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Translational Medicine<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s12967-019-2096-8" target="_blank">https://dx.doi.org/10.1186/s12967-019-2096-8</a></p>2019-10-22T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1186/s12967-019-2096-8https://figshare.com/articles/journal_contribution/Metabolic_signature_of_obesity-associated_insulin_resistance_and_type_2_diabetes/25886941CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/258869412019-10-22T03:00:00Z |
| spellingShingle | Metabolic signature of obesity-associated insulin resistance and type 2 diabetes Haya Al-Sulaiti (5449256) Biomedical and clinical sciences Medical biochemistry and metabolomics Metabolomics Blood metabolites Insulin sensitivity Insulin resistance Type 2 diabetes mellitus |
| status_str | publishedVersion |
| title | Metabolic signature of obesity-associated insulin resistance and type 2 diabetes |
| title_full | Metabolic signature of obesity-associated insulin resistance and type 2 diabetes |
| title_fullStr | Metabolic signature of obesity-associated insulin resistance and type 2 diabetes |
| title_full_unstemmed | Metabolic signature of obesity-associated insulin resistance and type 2 diabetes |
| title_short | Metabolic signature of obesity-associated insulin resistance and type 2 diabetes |
| title_sort | Metabolic signature of obesity-associated insulin resistance and type 2 diabetes |
| topic | Biomedical and clinical sciences Medical biochemistry and metabolomics Metabolomics Blood metabolites Insulin sensitivity Insulin resistance Type 2 diabetes mellitus |