The demographics of Tolosa-Hunt syndrome in Qatar
<h3>Background</h3><p dir="ltr">Tolosa Hunt syndrome (THS) is a rare disease that manifests mainly as painful unilateral ophthalmoplegia. It is caused by an inflammatory process of unknown aetiology within the cavernous sinus with a rare intracranial extension. The Intern...
محفوظ في:
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| مؤلفون آخرون: | , , , , , , , |
| منشور في: |
2021
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| الموضوعات: | |
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إضافة وسم
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| _version_ | 1864513547050942464 |
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| author | Fateen Ata (12217764) |
| author2 | Zohaib Yousaf (9617058) Suresh Nalaka Menik Arachchige (17269264) Saman Rose (17269267) Awni Alshurafa (15468195) Bassam Muthanna (14777407) Ammara Bint I Bilal (17269270) Ahmed El Beltagi (17269273) Muhammad Zahid (4510696) |
| author2_role | author author author author author author author author |
| author_facet | Fateen Ata (12217764) Zohaib Yousaf (9617058) Suresh Nalaka Menik Arachchige (17269264) Saman Rose (17269267) Awni Alshurafa (15468195) Bassam Muthanna (14777407) Ammara Bint I Bilal (17269270) Ahmed El Beltagi (17269273) Muhammad Zahid (4510696) |
| author_role | author |
| dc.creator.none.fl_str_mv | Fateen Ata (12217764) Zohaib Yousaf (9617058) Suresh Nalaka Menik Arachchige (17269264) Saman Rose (17269267) Awni Alshurafa (15468195) Bassam Muthanna (14777407) Ammara Bint I Bilal (17269270) Ahmed El Beltagi (17269273) Muhammad Zahid (4510696) |
| dc.date.none.fl_str_mv | 2021-09-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.ensci.2021.100359 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/The_demographics_of_Tolosa-Hunt_syndrome_in_Qatar/24420553 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Neurosciences Tolosa Hunt syndrome THS Cavernous sinus Ophthalmoplegia Third nerve palsy |
| dc.title.none.fl_str_mv | The demographics of Tolosa-Hunt syndrome in Qatar |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">Tolosa Hunt syndrome (THS) is a rare disease that manifests mainly as painful unilateral ophthalmoplegia. It is caused by an inflammatory process of unknown aetiology within the cavernous sinus with a rare intracranial extension. The International Classification of Headache Disorders (ICHD)- 3 diagnostic criteria aids in its diagnosis. There is limited literature on its varied presentations, diagnosis, and management. Steroids are used in the treatment of THS with varied success.</p><h3>Methods</h3><p dir="ltr">We conducted a single-center-retrospective-study and included all patients admitted with a diagnosis of THS from January 2015 to December 2020. Descriptive and summary statistics were used to describe the study cohort's socio-demographic parameters.</p><h3>Results</h3><p dir="ltr">Among 31 THS patients (predominantly Asians (18) and Arabs (9)), visual disturbance was commonest presenting complaint. Third-nerve paralysis was seen in 70.9% cases. Magnetic-resonance-imaging (MRI) was abnormal in 64.5%. 93.5% patients received steroids, with a response-rate of 70.9% and a recurrence-rate of 9.7%. A previous history of THS and female gender were associated with recurrence (p-value 0.009 and 0.018). Recurrence was seen in 66.7% fully recovered and 33.3% partially recovered cases (p-value 0.04). Among the benign and inflammatory subtypes of THS, the ICHD-3 criteria were applicable in 85% of inflammatory THS.</p><h3>Conclusions</h3><p dir="ltr">THS is a rare disease with ethnic variation in presentation and response to treatment. In our cohort female gender and a previous history of THS were associated with recurrence. ICHD-3 diagnostic criteria had a higher validity in our patients compared to prior studies, especially among the inflammatory THS.</p><h2>Other Information</h2><p dir="ltr">Published in: eNeurologicalSci<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.ensci.2021.100359" target="_blank">https://dx.doi.org/10.1016/j.ensci.2021.100359</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_0afee0efd871e7eb935af9c5327f039a |
| identifier_str_mv | 10.1016/j.ensci.2021.100359 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24420553 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | The demographics of Tolosa-Hunt syndrome in QatarFateen Ata (12217764)Zohaib Yousaf (9617058)Suresh Nalaka Menik Arachchige (17269264)Saman Rose (17269267)Awni Alshurafa (15468195)Bassam Muthanna (14777407)Ammara Bint I Bilal (17269270)Ahmed El Beltagi (17269273)Muhammad Zahid (4510696)Biomedical and clinical sciencesNeurosciencesTolosa Hunt syndromeTHSCavernous sinusOphthalmoplegiaThird nerve palsy<h3>Background</h3><p dir="ltr">Tolosa Hunt syndrome (THS) is a rare disease that manifests mainly as painful unilateral ophthalmoplegia. It is caused by an inflammatory process of unknown aetiology within the cavernous sinus with a rare intracranial extension. The International Classification of Headache Disorders (ICHD)- 3 diagnostic criteria aids in its diagnosis. There is limited literature on its varied presentations, diagnosis, and management. Steroids are used in the treatment of THS with varied success.</p><h3>Methods</h3><p dir="ltr">We conducted a single-center-retrospective-study and included all patients admitted with a diagnosis of THS from January 2015 to December 2020. Descriptive and summary statistics were used to describe the study cohort's socio-demographic parameters.</p><h3>Results</h3><p dir="ltr">Among 31 THS patients (predominantly Asians (18) and Arabs (9)), visual disturbance was commonest presenting complaint. Third-nerve paralysis was seen in 70.9% cases. Magnetic-resonance-imaging (MRI) was abnormal in 64.5%. 93.5% patients received steroids, with a response-rate of 70.9% and a recurrence-rate of 9.7%. A previous history of THS and female gender were associated with recurrence (p-value 0.009 and 0.018). Recurrence was seen in 66.7% fully recovered and 33.3% partially recovered cases (p-value 0.04). Among the benign and inflammatory subtypes of THS, the ICHD-3 criteria were applicable in 85% of inflammatory THS.</p><h3>Conclusions</h3><p dir="ltr">THS is a rare disease with ethnic variation in presentation and response to treatment. In our cohort female gender and a previous history of THS were associated with recurrence. ICHD-3 diagnostic criteria had a higher validity in our patients compared to prior studies, especially among the inflammatory THS.</p><h2>Other Information</h2><p dir="ltr">Published in: eNeurologicalSci<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.ensci.2021.100359" target="_blank">https://dx.doi.org/10.1016/j.ensci.2021.100359</a></p>2021-09-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.ensci.2021.100359https://figshare.com/articles/journal_contribution/The_demographics_of_Tolosa-Hunt_syndrome_in_Qatar/24420553CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/244205532021-09-01T00:00:00Z |
| spellingShingle | The demographics of Tolosa-Hunt syndrome in Qatar Fateen Ata (12217764) Biomedical and clinical sciences Neurosciences Tolosa Hunt syndrome THS Cavernous sinus Ophthalmoplegia Third nerve palsy |
| status_str | publishedVersion |
| title | The demographics of Tolosa-Hunt syndrome in Qatar |
| title_full | The demographics of Tolosa-Hunt syndrome in Qatar |
| title_fullStr | The demographics of Tolosa-Hunt syndrome in Qatar |
| title_full_unstemmed | The demographics of Tolosa-Hunt syndrome in Qatar |
| title_short | The demographics of Tolosa-Hunt syndrome in Qatar |
| title_sort | The demographics of Tolosa-Hunt syndrome in Qatar |
| topic | Biomedical and clinical sciences Neurosciences Tolosa Hunt syndrome THS Cavernous sinus Ophthalmoplegia Third nerve palsy |