Systemic Inflammation May Induce Cardiac Injury in COVID-19 Patients Including Children and Adolescents Without Underlying Cardiovascular Diseases: A Systematic Review
<p dir="ltr">Coronavirus disease 2019(COVID-19) is an ongoing global pandemic with a daily increasing number of affected individuals and a relatively high mortality rate. COVID-19 patients that develop cardiac injury are at increased risk of a worse clinical course with higher rates...
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2022
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| _version_ | 1864513545114222592 |
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| author | Arwa Saed Aldien (17302849) |
| author2 | Gowrii S. Ganesan (17302852) Farah Wahbeh (13192175) Noor Al-Nassr (17302855) Heba Altarawneh (17302858) Lolwa Al Theyab (17302861) Summia Saed Aldien (17302864) Sara Tomerak (14683597) Hiba Naveed (14683591) Mohamed B. Elshazly (14779456) Dalia Zakaria (14779459) |
| author2_role | author author author author author author author author author author |
| author_facet | Arwa Saed Aldien (17302849) Gowrii S. Ganesan (17302852) Farah Wahbeh (13192175) Noor Al-Nassr (17302855) Heba Altarawneh (17302858) Lolwa Al Theyab (17302861) Summia Saed Aldien (17302864) Sara Tomerak (14683597) Hiba Naveed (14683591) Mohamed B. Elshazly (14779456) Dalia Zakaria (14779459) |
| author_role | author |
| dc.creator.none.fl_str_mv | Arwa Saed Aldien (17302849) Gowrii S. Ganesan (17302852) Farah Wahbeh (13192175) Noor Al-Nassr (17302855) Heba Altarawneh (17302858) Lolwa Al Theyab (17302861) Summia Saed Aldien (17302864) Sara Tomerak (14683597) Hiba Naveed (14683591) Mohamed B. Elshazly (14779456) Dalia Zakaria (14779459) |
| dc.date.none.fl_str_mv | 2022-02-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.carrev.2021.04.007 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Systemic_Inflammation_May_Induce_Cardiac_Injury_in_COVID-19_Patients_Including_Children_and_Adolescents_Without_Underlying_Cardiovascular_Diseases_A_Systematic_Review/24459133 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Coronavirus COVID-19 Inflammation Cardiac injury Myocarditis |
| dc.title.none.fl_str_mv | Systemic Inflammation May Induce Cardiac Injury in COVID-19 Patients Including Children and Adolescents Without Underlying Cardiovascular Diseases: A Systematic Review |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Coronavirus disease 2019(COVID-19) is an ongoing global pandemic with a daily increasing number of affected individuals and a relatively high mortality rate. COVID-19 patients that develop cardiac injury are at increased risk of a worse clinical course with higher rates of mortality. Increasing amounts of evidence suggest that a system-wide inflammatory response and a cytokine storm mediated type syndrome plays a crucial role in disease progression. This systematic review investigates the possible role of hyperinflammation in inducing cardiac injury as one of the severe complications of COVID-19. A systematic literature search was performed using PubMed, Embase and Scopus databases to identify relevant clinical studies that investigated cardiovascular injury manifestations and reported inflammatory and cardiac biomarkers in COVID-19 patients. Only 29 studies met our inclusion criteria and the majority of these studies demonstrated significantly elevated inflammatory and cardiac blood markers. It was evident that underlying cardiovascular diseases may increase the risk of developing cardiac injury. However, many COVID-19 patients included in this review, developed different types of cardiac injury without having any underlying cardiovascular diseases. Furthermore, many of these patients were either children or adolescents. Therefore, age and comorbidities may not always be the two main risk factors that dictate the severity and outcome of COVID-19. Further investigations are required to understand the underlying mechanisms of pathogenicity as an urgent requirement to develop the appropriate treatment and prevention strategies. These strategies may specifically target hyperinflammation as a suspected driving factor for some of the severe complications of COVID-19.</p><h2>Other Information</h2><p dir="ltr">Published in: Cardiovascular Revascularization Medicine<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.carrev.2021.04.007" target="_blank">https://dx.doi.org/10.1016/j.carrev.2021.04.007</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_0b04819075b300068afbbd62c306eebb |
| identifier_str_mv | 10.1016/j.carrev.2021.04.007 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24459133 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Systemic Inflammation May Induce Cardiac Injury in COVID-19 Patients Including Children and Adolescents Without Underlying Cardiovascular Diseases: A Systematic ReviewArwa Saed Aldien (17302849)Gowrii S. Ganesan (17302852)Farah Wahbeh (13192175)Noor Al-Nassr (17302855)Heba Altarawneh (17302858)Lolwa Al Theyab (17302861)Summia Saed Aldien (17302864)Sara Tomerak (14683597)Hiba Naveed (14683591)Mohamed B. Elshazly (14779456)Dalia Zakaria (14779459)Biomedical and clinical sciencesCardiovascular medicine and haematologyCoronavirusCOVID-19InflammationCardiac injuryMyocarditis<p dir="ltr">Coronavirus disease 2019(COVID-19) is an ongoing global pandemic with a daily increasing number of affected individuals and a relatively high mortality rate. COVID-19 patients that develop cardiac injury are at increased risk of a worse clinical course with higher rates of mortality. Increasing amounts of evidence suggest that a system-wide inflammatory response and a cytokine storm mediated type syndrome plays a crucial role in disease progression. This systematic review investigates the possible role of hyperinflammation in inducing cardiac injury as one of the severe complications of COVID-19. A systematic literature search was performed using PubMed, Embase and Scopus databases to identify relevant clinical studies that investigated cardiovascular injury manifestations and reported inflammatory and cardiac biomarkers in COVID-19 patients. Only 29 studies met our inclusion criteria and the majority of these studies demonstrated significantly elevated inflammatory and cardiac blood markers. It was evident that underlying cardiovascular diseases may increase the risk of developing cardiac injury. However, many COVID-19 patients included in this review, developed different types of cardiac injury without having any underlying cardiovascular diseases. Furthermore, many of these patients were either children or adolescents. Therefore, age and comorbidities may not always be the two main risk factors that dictate the severity and outcome of COVID-19. Further investigations are required to understand the underlying mechanisms of pathogenicity as an urgent requirement to develop the appropriate treatment and prevention strategies. These strategies may specifically target hyperinflammation as a suspected driving factor for some of the severe complications of COVID-19.</p><h2>Other Information</h2><p dir="ltr">Published in: Cardiovascular Revascularization Medicine<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.carrev.2021.04.007" target="_blank">https://dx.doi.org/10.1016/j.carrev.2021.04.007</a></p>2022-02-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.carrev.2021.04.007https://figshare.com/articles/journal_contribution/Systemic_Inflammation_May_Induce_Cardiac_Injury_in_COVID-19_Patients_Including_Children_and_Adolescents_Without_Underlying_Cardiovascular_Diseases_A_Systematic_Review/24459133CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/244591332022-02-01T00:00:00Z |
| spellingShingle | Systemic Inflammation May Induce Cardiac Injury in COVID-19 Patients Including Children and Adolescents Without Underlying Cardiovascular Diseases: A Systematic Review Arwa Saed Aldien (17302849) Biomedical and clinical sciences Cardiovascular medicine and haematology Coronavirus COVID-19 Inflammation Cardiac injury Myocarditis |
| status_str | publishedVersion |
| title | Systemic Inflammation May Induce Cardiac Injury in COVID-19 Patients Including Children and Adolescents Without Underlying Cardiovascular Diseases: A Systematic Review |
| title_full | Systemic Inflammation May Induce Cardiac Injury in COVID-19 Patients Including Children and Adolescents Without Underlying Cardiovascular Diseases: A Systematic Review |
| title_fullStr | Systemic Inflammation May Induce Cardiac Injury in COVID-19 Patients Including Children and Adolescents Without Underlying Cardiovascular Diseases: A Systematic Review |
| title_full_unstemmed | Systemic Inflammation May Induce Cardiac Injury in COVID-19 Patients Including Children and Adolescents Without Underlying Cardiovascular Diseases: A Systematic Review |
| title_short | Systemic Inflammation May Induce Cardiac Injury in COVID-19 Patients Including Children and Adolescents Without Underlying Cardiovascular Diseases: A Systematic Review |
| title_sort | Systemic Inflammation May Induce Cardiac Injury in COVID-19 Patients Including Children and Adolescents Without Underlying Cardiovascular Diseases: A Systematic Review |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Coronavirus COVID-19 Inflammation Cardiac injury Myocarditis |