Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss

Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss

<p dir="ltr">Age-related hearing loss (ARHL) is the most common sensory deficit in the elderly. The disease has a multifactorial etiology with both environmental and genetic factors involved being largely unknown. SLC7A8/SLC3A2 heterodimer is a neutral amino acid exchanger. Here, we...

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Bibliographic Details
Main Author: Meritxell Espino Guarch (18810097) (author)
Other Authors: Mariona Font-Llitjós (562770) (author), Silvia Murillo-Cuesta (519611) (author), Ekaitz Errasti- Murugarren (18810100) (author), Adelaida M Celaya (18810103) (author), Giorgia Girotto (149894) (author), Dragana Vuckovic (491541) (author), Massimo Mezzavilla (535235) (author), Clara Vilches (794255) (author), Susanna Bodoy (18810106) (author), Ignasi Sahún (18810109) (author), Laura González (4708861) (author), Esther Prat (794256) (author), Antonio Zorzano (35886) (author), Mara Dierssen (51655) (author), Isabel Varela-Nieto (186892) (author), Paolo Gasparini (139832) (author), Manuel Palacín (5649286) (author), Virginia Nunes (40884) (author)
Published: 2018
Subjects:
Biomedical and clinical sciences
Clinical sciences
Medical biochemistry and metabolomics
Chemical sciences
Medicinal and biomolecular chemistry
Age-related hearing loss
SLC7A8 protein
Genetics
Inner ear damage
Hearing impairment
Genetic mutations
Protein function
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