Expanding the store-operated Ca<sup>2+</sup> entry microdomain through Ca<sup>2+</sup> tunneling
<p dir="ltr">Ca<sup>2+</sup> is unique among second messenger in terms of its spatial and temporal breadth. On the spatial level Ca<sup>2+</sup> signals extend from nm to cm scales (seven orders of magnitude), and in the temporal dimension it signals in the ra...
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2020
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| Summary: | <p dir="ltr">Ca<sup>2+</sup> is unique among second messenger in terms of its spatial and temporal breadth. On the spatial level Ca<sup>2+</sup> signals extend from nm to cm scales (seven orders of magnitude), and in the temporal dimension it signals in the range of μsec to hours (nine orders of magnitude). Furthermore, Ca<sup>2+</sup> activates with exquisite specificity diverse, often opposing, cellular events. How Ca<sup>2+</sup> achieves such a broad spatial and temporal coverage while maintaining signaling specificity is an area of active research with cell type specific nuances. Here, we discuss one modality of Ca<sup>2+</sup> signaling that operates downstream of store-operated Ca<sup>2+</sup> entry (SOCE), known as Ca<sup>2+</sup> tunneling, that expands SOCE signaling while maintaining specificity. We focus on recent findings that argue that Ca<sup>2+</sup> tunneling has been adapted for cortical signaling.</p><h2>Other Information</h2><p dir="ltr">Published in: Current Opinion in Physiology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.cophys.2020.08.015" target="_blank">https://dx.doi.org/10.1016/j.cophys.2020.08.015</a></p> |
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