Characteristic MicroRNAs Linked to Dysregulated Metabolic Pathways in Qatari Adult Subjects With Obesity and Metabolic Syndrome
<h3>Background</h3><p dir="ltr">Obesity-associated dysglycemia is associated with metabolic disorders. MicroRNAs (miRNAs) are known regulators of metabolic homeostasis. We aimed to assess the relationship of circulating miRNAs with clinical features in obese Qatari indivi...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , , , , |
| منشور في: |
2022
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| الموضوعات: | |
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إضافة وسم
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| _version_ | 1864513518007484416 |
|---|---|
| author | Fayaz Ahmad Mir (11828354) |
| author2 | Raghvendra Mall (581171) Ahmad Iskandarani (3520067) Ehsan Ullah (2698921) Tareq A. Samra (9440765) Farhan Cyprian (12829466) Aijaz Parray (290256) Meis Alkasem (9440768) Ibrahem Abdalhakam (13134576) Faisal Farooq (13134579) Abdul-Badi Abou-Samra (3411167) |
| author2_role | author author author author author author author author author author |
| author_facet | Fayaz Ahmad Mir (11828354) Raghvendra Mall (581171) Ahmad Iskandarani (3520067) Ehsan Ullah (2698921) Tareq A. Samra (9440765) Farhan Cyprian (12829466) Aijaz Parray (290256) Meis Alkasem (9440768) Ibrahem Abdalhakam (13134576) Faisal Farooq (13134579) Abdul-Badi Abou-Samra (3411167) |
| author_role | author |
| dc.creator.none.fl_str_mv | Fayaz Ahmad Mir (11828354) Raghvendra Mall (581171) Ahmad Iskandarani (3520067) Ehsan Ullah (2698921) Tareq A. Samra (9440765) Farhan Cyprian (12829466) Aijaz Parray (290256) Meis Alkasem (9440768) Ibrahem Abdalhakam (13134576) Faisal Farooq (13134579) Abdul-Badi Abou-Samra (3411167) |
| dc.date.none.fl_str_mv | 2022-07-22T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3389/fendo.2022.937089 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Characteristic_MicroRNAs_Linked_to_Dysregulated_Metabolic_Pathways_in_Qatari_Adult_Subjects_With_Obesity_and_Metabolic_Syndrome/25679844 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Neurosciences miRNA metabolic disorder HbA1c obesity mirDIP network analysis |
| dc.title.none.fl_str_mv | Characteristic MicroRNAs Linked to Dysregulated Metabolic Pathways in Qatari Adult Subjects With Obesity and Metabolic Syndrome |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">Obesity-associated dysglycemia is associated with metabolic disorders. MicroRNAs (miRNAs) are known regulators of metabolic homeostasis. We aimed to assess the relationship of circulating miRNAs with clinical features in obese Qatari individuals.</p><h3>Methods</h3><p dir="ltr">We analyzed a dataset of 39 age-matched patients that includes 18 subjects with obesity only (OBO) and 21 subjects with obesity and metabolic syndrome (OBM). We measured 754 well-characterized human microRNAs (miRNAs) and identified differentially expressed miRNAs along with their significant associations with clinical markers in these patients.</p><h3>Results</h3><p dir="ltr">A total of 64 miRNAs were differentially expressed between metabolically healthy obese (OBO) versus metabolically unhealthy obese (OBM) patients. Thirteen out of 64 miRNAs significantly correlated with at least one clinical trait of the metabolic syndrome. Six out of the thirteen demonstrated significant association with HbA1c levels; miR-331-3p, miR-452-3p, and miR-485-5p were over-expressed, whereas miR-153-3p, miR-182-5p, and miR-433-3p were under-expressed in the OBM patients with elevated HbA1c levels. We also identified, miR-106b-3p, miR-652-3p, and miR-93-5p that showed a significant association with creatinine; miR-130b-5p, miR-363-3p, and miR-636 were significantly associated with cholesterol, whereas miR-130a-3p was significantly associated with LDL. Additionally, miR-652-3p’s differential expression correlated significantly with HDL and creatinine.</p><h3>Conclusions</h3><p dir="ltr">MicroRNAs associated with metabolic syndrome in obese subjects may have a pathophysiologic role and can serve as markers for obese individuals predisposed to various metabolic diseases like diabetes.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Endocrinology<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fendo.2022.937089" target="_blank">https://dx.doi.org/10.3389/fendo.2022.937089</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_0c371c54b51d7f153a28ac5c45698e0a |
| identifier_str_mv | 10.3389/fendo.2022.937089 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25679844 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Characteristic MicroRNAs Linked to Dysregulated Metabolic Pathways in Qatari Adult Subjects With Obesity and Metabolic SyndromeFayaz Ahmad Mir (11828354)Raghvendra Mall (581171)Ahmad Iskandarani (3520067)Ehsan Ullah (2698921)Tareq A. Samra (9440765)Farhan Cyprian (12829466)Aijaz Parray (290256)Meis Alkasem (9440768)Ibrahem Abdalhakam (13134576)Faisal Farooq (13134579)Abdul-Badi Abou-Samra (3411167)Biomedical and clinical sciencesNeurosciencesmiRNAmetabolic disorderHbA1cobesitymirDIPnetwork analysis<h3>Background</h3><p dir="ltr">Obesity-associated dysglycemia is associated with metabolic disorders. MicroRNAs (miRNAs) are known regulators of metabolic homeostasis. We aimed to assess the relationship of circulating miRNAs with clinical features in obese Qatari individuals.</p><h3>Methods</h3><p dir="ltr">We analyzed a dataset of 39 age-matched patients that includes 18 subjects with obesity only (OBO) and 21 subjects with obesity and metabolic syndrome (OBM). We measured 754 well-characterized human microRNAs (miRNAs) and identified differentially expressed miRNAs along with their significant associations with clinical markers in these patients.</p><h3>Results</h3><p dir="ltr">A total of 64 miRNAs were differentially expressed between metabolically healthy obese (OBO) versus metabolically unhealthy obese (OBM) patients. Thirteen out of 64 miRNAs significantly correlated with at least one clinical trait of the metabolic syndrome. Six out of the thirteen demonstrated significant association with HbA1c levels; miR-331-3p, miR-452-3p, and miR-485-5p were over-expressed, whereas miR-153-3p, miR-182-5p, and miR-433-3p were under-expressed in the OBM patients with elevated HbA1c levels. We also identified, miR-106b-3p, miR-652-3p, and miR-93-5p that showed a significant association with creatinine; miR-130b-5p, miR-363-3p, and miR-636 were significantly associated with cholesterol, whereas miR-130a-3p was significantly associated with LDL. Additionally, miR-652-3p’s differential expression correlated significantly with HDL and creatinine.</p><h3>Conclusions</h3><p dir="ltr">MicroRNAs associated with metabolic syndrome in obese subjects may have a pathophysiologic role and can serve as markers for obese individuals predisposed to various metabolic diseases like diabetes.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Endocrinology<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fendo.2022.937089" target="_blank">https://dx.doi.org/10.3389/fendo.2022.937089</a></p>2022-07-22T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3389/fendo.2022.937089https://figshare.com/articles/journal_contribution/Characteristic_MicroRNAs_Linked_to_Dysregulated_Metabolic_Pathways_in_Qatari_Adult_Subjects_With_Obesity_and_Metabolic_Syndrome/25679844CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/256798442022-07-22T03:00:00Z |
| spellingShingle | Characteristic MicroRNAs Linked to Dysregulated Metabolic Pathways in Qatari Adult Subjects With Obesity and Metabolic Syndrome Fayaz Ahmad Mir (11828354) Biomedical and clinical sciences Neurosciences miRNA metabolic disorder HbA1c obesity mirDIP network analysis |
| status_str | publishedVersion |
| title | Characteristic MicroRNAs Linked to Dysregulated Metabolic Pathways in Qatari Adult Subjects With Obesity and Metabolic Syndrome |
| title_full | Characteristic MicroRNAs Linked to Dysregulated Metabolic Pathways in Qatari Adult Subjects With Obesity and Metabolic Syndrome |
| title_fullStr | Characteristic MicroRNAs Linked to Dysregulated Metabolic Pathways in Qatari Adult Subjects With Obesity and Metabolic Syndrome |
| title_full_unstemmed | Characteristic MicroRNAs Linked to Dysregulated Metabolic Pathways in Qatari Adult Subjects With Obesity and Metabolic Syndrome |
| title_short | Characteristic MicroRNAs Linked to Dysregulated Metabolic Pathways in Qatari Adult Subjects With Obesity and Metabolic Syndrome |
| title_sort | Characteristic MicroRNAs Linked to Dysregulated Metabolic Pathways in Qatari Adult Subjects With Obesity and Metabolic Syndrome |
| topic | Biomedical and clinical sciences Neurosciences miRNA metabolic disorder HbA1c obesity mirDIP network analysis |