Does standalone phacoemulsification lower intraocular pressure in glaucomatous eyes? A systematic review and meta-analysis
<p dir="ltr">We evaluated the effect of phacoemulsification on intraocular pressure (IOP) and the reduction of glaucoma medications in patients with glaucoma. Our protocol was registered in PROSPERO (CRD42024533437). We conducted a systematic search in PubMed, Scopus, Cochrane Centra...
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2025
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| _version_ | 1864513531490074624 |
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| author | Osama Hussein (21301202) |
| author2 | Ayman Musleh (22927915) Yara Abukhaled (22927918) Abdullah Hammad (15221695) Radi Feras (22927921) Hashem Abu Serhan (16003271) |
| author2_role | author author author author author |
| author_facet | Osama Hussein (21301202) Ayman Musleh (22927915) Yara Abukhaled (22927918) Abdullah Hammad (15221695) Radi Feras (22927921) Hashem Abu Serhan (16003271) |
| author_role | author |
| dc.creator.none.fl_str_mv | Osama Hussein (21301202) Ayman Musleh (22927915) Yara Abukhaled (22927918) Abdullah Hammad (15221695) Radi Feras (22927921) Hashem Abu Serhan (16003271) |
| dc.date.none.fl_str_mv | 2025-07-24T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1038/s41433-025-03927-7 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Does_standalone_phacoemulsification_lower_intraocular_pressure_in_glaucomatous_eyes_A_systematic_review_and_meta-analysis/30971128 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Pharmacology and pharmaceutical sciences Phacoemulsification Open-Angle Glaucoma (OAG) Angle-Closure Glaucoma (ACG) Glaucoma Intraocular Pressure (IOP) |
| dc.title.none.fl_str_mv | Does standalone phacoemulsification lower intraocular pressure in glaucomatous eyes? A systematic review and meta-analysis |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">We evaluated the effect of phacoemulsification on intraocular pressure (IOP) and the reduction of glaucoma medications in patients with glaucoma. Our protocol was registered in PROSPERO (CRD42024533437). We conducted a systematic search in PubMed, Scopus, Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Science for randomized clinical trials (RCTs) with at least 10 eyes and a 12-month minimum follow-up. Risk of bias assessment was performed using the Cochrane risk-of-bias tool. A random-effects model meta-analysis was used, and heterogeneity was assessed using Cochran’s Q and I² statistics. We included 41 RCTs with a total of 2315 eyes in the phacoemulsification-alone group. In ACG patients, the pooled effect showed a percentage of IOP reduction (IOPR%) of 35.22% with a mean IOP reduction of −9.51 mmHg, <i>p</i>< 0.001 at 12 months, and an IOPR% of 27.47% with a mean reduction of −6.37 mmHg, <i>p</i> < 0.001 at 24 months. For OAG patients, the pooled effect showed an IOPR% of 18.94% with a significant absolute change of −4.35 mmHg, <i>p</i> < 0.001 at 12 months, and IOPR% of 16.95% with an absolute IOP change of −3.83 mmHg, <i>p</i> < 0.001 at 24 months. In ACG patients, medication use decreased by 67.13% at 12 months and 51.58% at 24 months (<i>p</i> < 0.001 for both), while in OAG patients, the reduction was 45.52% at 12 months and 50.19% at 24 months (<i>p</i> < 0.001). In conclusion, standalone phacoemulsification significantly lowers IOP and reduces the need for glaucoma medications in patients with glaucoma.</p><h2 dir="ltr">Other Information</h2><p dir="ltr">Published in: Eye<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1038/s41433-025-03927-7" target="_blank">https://dx.doi.org/10.1038/s41433-025-03927-7</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_0c7b9a67873220e71bac467e8589132b |
| identifier_str_mv | 10.1038/s41433-025-03927-7 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/30971128 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Does standalone phacoemulsification lower intraocular pressure in glaucomatous eyes? A systematic review and meta-analysisOsama Hussein (21301202)Ayman Musleh (22927915)Yara Abukhaled (22927918)Abdullah Hammad (15221695)Radi Feras (22927921)Hashem Abu Serhan (16003271)Biomedical and clinical sciencesClinical sciencesPharmacology and pharmaceutical sciencesPhacoemulsificationOpen-Angle Glaucoma (OAG)Angle-Closure Glaucoma (ACG)GlaucomaIntraocular Pressure (IOP)<p dir="ltr">We evaluated the effect of phacoemulsification on intraocular pressure (IOP) and the reduction of glaucoma medications in patients with glaucoma. Our protocol was registered in PROSPERO (CRD42024533437). We conducted a systematic search in PubMed, Scopus, Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Science for randomized clinical trials (RCTs) with at least 10 eyes and a 12-month minimum follow-up. Risk of bias assessment was performed using the Cochrane risk-of-bias tool. A random-effects model meta-analysis was used, and heterogeneity was assessed using Cochran’s Q and I² statistics. We included 41 RCTs with a total of 2315 eyes in the phacoemulsification-alone group. In ACG patients, the pooled effect showed a percentage of IOP reduction (IOPR%) of 35.22% with a mean IOP reduction of −9.51 mmHg, <i>p</i>< 0.001 at 12 months, and an IOPR% of 27.47% with a mean reduction of −6.37 mmHg, <i>p</i> < 0.001 at 24 months. For OAG patients, the pooled effect showed an IOPR% of 18.94% with a significant absolute change of −4.35 mmHg, <i>p</i> < 0.001 at 12 months, and IOPR% of 16.95% with an absolute IOP change of −3.83 mmHg, <i>p</i> < 0.001 at 24 months. In ACG patients, medication use decreased by 67.13% at 12 months and 51.58% at 24 months (<i>p</i> < 0.001 for both), while in OAG patients, the reduction was 45.52% at 12 months and 50.19% at 24 months (<i>p</i> < 0.001). In conclusion, standalone phacoemulsification significantly lowers IOP and reduces the need for glaucoma medications in patients with glaucoma.</p><h2 dir="ltr">Other Information</h2><p dir="ltr">Published in: Eye<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1038/s41433-025-03927-7" target="_blank">https://dx.doi.org/10.1038/s41433-025-03927-7</a></p>2025-07-24T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1038/s41433-025-03927-7https://figshare.com/articles/journal_contribution/Does_standalone_phacoemulsification_lower_intraocular_pressure_in_glaucomatous_eyes_A_systematic_review_and_meta-analysis/30971128CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/309711282025-07-24T09:00:00Z |
| spellingShingle | Does standalone phacoemulsification lower intraocular pressure in glaucomatous eyes? A systematic review and meta-analysis Osama Hussein (21301202) Biomedical and clinical sciences Clinical sciences Pharmacology and pharmaceutical sciences Phacoemulsification Open-Angle Glaucoma (OAG) Angle-Closure Glaucoma (ACG) Glaucoma Intraocular Pressure (IOP) |
| status_str | publishedVersion |
| title | Does standalone phacoemulsification lower intraocular pressure in glaucomatous eyes? A systematic review and meta-analysis |
| title_full | Does standalone phacoemulsification lower intraocular pressure in glaucomatous eyes? A systematic review and meta-analysis |
| title_fullStr | Does standalone phacoemulsification lower intraocular pressure in glaucomatous eyes? A systematic review and meta-analysis |
| title_full_unstemmed | Does standalone phacoemulsification lower intraocular pressure in glaucomatous eyes? A systematic review and meta-analysis |
| title_short | Does standalone phacoemulsification lower intraocular pressure in glaucomatous eyes? A systematic review and meta-analysis |
| title_sort | Does standalone phacoemulsification lower intraocular pressure in glaucomatous eyes? A systematic review and meta-analysis |
| topic | Biomedical and clinical sciences Clinical sciences Pharmacology and pharmaceutical sciences Phacoemulsification Open-Angle Glaucoma (OAG) Angle-Closure Glaucoma (ACG) Glaucoma Intraocular Pressure (IOP) |