Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson’s Disease
<p>Converging lines of evidence indicate that near-infrared light treatment, also known as photobiomodulation (PBM), may exert beneficial effects and protect against cellular toxicity and degeneration in several animal models of human pathologies, including neurodegenerative disorders. In the...
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| مؤلفون آخرون: | , , , , , |
| منشور في: |
2015
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| _version_ | 1864513505711882240 |
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| author | Abid Oueslati (816135) |
| author2 | Blaise Lovisa (482630) John Perrin (816136) Georges Wagnières (482631) Hubert van den Bergh (482632) Yanik Tardy (482634) Hilal A. Lashuel (261037) |
| author2_role | author author author author author author |
| author_facet | Abid Oueslati (816135) Blaise Lovisa (482630) John Perrin (816136) Georges Wagnières (482631) Hubert van den Bergh (482632) Yanik Tardy (482634) Hilal A. Lashuel (261037) |
| author_role | author |
| dc.creator.none.fl_str_mv | Abid Oueslati (816135) Blaise Lovisa (482630) John Perrin (816136) Georges Wagnières (482631) Hubert van den Bergh (482632) Yanik Tardy (482634) Hilal A. Lashuel (261037) |
| dc.date.none.fl_str_mv | 2015-10-20T06:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pone.0140880 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Photobiomodulation_Suppresses_Alpha-Synuclein-Induced_Toxicity_in_an_AAV-Based_Rat_Genetic_Model_of_Parkinson_s_Disease/26977186 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Medical biotechnology Neurosciences Dopaminergics Parkinson disease Near-infrared spectroscopy Neurons Light Substantia nigra Neostriatum Toxicity |
| dc.title.none.fl_str_mv | Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson’s Disease |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p>Converging lines of evidence indicate that near-infrared light treatment, also known as photobiomodulation (PBM), may exert beneficial effects and protect against cellular toxicity and degeneration in several animal models of human pathologies, including neurodegenerative disorders. In the present study, we report that chronic PMB treatment mitigates dopaminergic loss induced by unilateral overexpression of human α-synuclein (α-syn) in the substantia nigra of an AAV-based rat genetic model of Parkinson’s disease (PD). In this model, daily exposure of both sides of the rat’s head to 808-nm near-infrared light for 28 consecutive days alleviated α-syn-induced motor impairment, as assessed using the cylinder test. This treatment also significantly reduced dopaminergic neuronal loss in the injected substantia nigra and preserved dopaminergic fibers in the ipsilateral striatum. These beneficial effects were sustained for at least 6 weeks after discontinuing the treatment. Together, our data point to PBM as a possible therapeutic strategy for the treatment of PD and other related synucleinopathies.</p><h2>Other Information</h2> <p> Published in: PLOS ONE<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1371/journal.pone.0140880" target="_blank">https://dx.doi.org/10.1371/journal.pone.0140880</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_0ddbe9879afb37d799310d7c4a9516c0 |
| identifier_str_mv | 10.1371/journal.pone.0140880 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/26977186 |
| publishDate | 2015 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson’s DiseaseAbid Oueslati (816135)Blaise Lovisa (482630)John Perrin (816136)Georges Wagnières (482631)Hubert van den Bergh (482632)Yanik Tardy (482634)Hilal A. Lashuel (261037)Biomedical and clinical sciencesClinical sciencesMedical biotechnologyNeurosciencesDopaminergicsParkinson diseaseNear-infrared spectroscopyNeuronsLightSubstantia nigraNeostriatumToxicity<p>Converging lines of evidence indicate that near-infrared light treatment, also known as photobiomodulation (PBM), may exert beneficial effects and protect against cellular toxicity and degeneration in several animal models of human pathologies, including neurodegenerative disorders. In the present study, we report that chronic PMB treatment mitigates dopaminergic loss induced by unilateral overexpression of human α-synuclein (α-syn) in the substantia nigra of an AAV-based rat genetic model of Parkinson’s disease (PD). In this model, daily exposure of both sides of the rat’s head to 808-nm near-infrared light for 28 consecutive days alleviated α-syn-induced motor impairment, as assessed using the cylinder test. This treatment also significantly reduced dopaminergic neuronal loss in the injected substantia nigra and preserved dopaminergic fibers in the ipsilateral striatum. These beneficial effects were sustained for at least 6 weeks after discontinuing the treatment. Together, our data point to PBM as a possible therapeutic strategy for the treatment of PD and other related synucleinopathies.</p><h2>Other Information</h2> <p> Published in: PLOS ONE<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1371/journal.pone.0140880" target="_blank">https://dx.doi.org/10.1371/journal.pone.0140880</a></p>2015-10-20T06:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1371/journal.pone.0140880https://figshare.com/articles/journal_contribution/Photobiomodulation_Suppresses_Alpha-Synuclein-Induced_Toxicity_in_an_AAV-Based_Rat_Genetic_Model_of_Parkinson_s_Disease/26977186CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/269771862015-10-20T06:00:00Z |
| spellingShingle | Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson’s Disease Abid Oueslati (816135) Biomedical and clinical sciences Clinical sciences Medical biotechnology Neurosciences Dopaminergics Parkinson disease Near-infrared spectroscopy Neurons Light Substantia nigra Neostriatum Toxicity |
| status_str | publishedVersion |
| title | Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson’s Disease |
| title_full | Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson’s Disease |
| title_fullStr | Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson’s Disease |
| title_full_unstemmed | Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson’s Disease |
| title_short | Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson’s Disease |
| title_sort | Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson’s Disease |
| topic | Biomedical and clinical sciences Clinical sciences Medical biotechnology Neurosciences Dopaminergics Parkinson disease Near-infrared spectroscopy Neurons Light Substantia nigra Neostriatum Toxicity |