Circulating miRNAs, Small but Promising Biomarkers for Autism Spectrum Disorder
<p dir="ltr">Autism spectrum disorder (ASD) refers to a heterogeneous group of complex neurodevelopmental disorders characterized by social skill and communication deficits, along with stereotyped repetitive behavior. miRNAs, small non-coding RNAs that have been recognized as critica...
محفوظ في:
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| مؤلفون آخرون: | , |
| منشور في: |
2019
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| _version_ | 1864513514052255744 |
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| author | Salam Salloum-Asfar (656363) |
| author2 | Noothan J. Satheesh (18615121) Sara A. Abdulla (13902015) |
| author2_role | author author |
| author_facet | Salam Salloum-Asfar (656363) Noothan J. Satheesh (18615121) Sara A. Abdulla (13902015) |
| author_role | author |
| dc.creator.none.fl_str_mv | Salam Salloum-Asfar (656363) Noothan J. Satheesh (18615121) Sara A. Abdulla (13902015) |
| dc.date.none.fl_str_mv | 2019-10-11T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3389/fnmol.2019.00253 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Circulating_miRNAs_Small_but_Promising_Biomarkers_for_Autism_Spectrum_Disorder/25904416 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Genetics Biomedical and clinical sciences Neurosciences neurodevelopmental disorders circulating miRNA biomarkers Autism Spectrum Disorder microRNA biofluid analysis |
| dc.title.none.fl_str_mv | Circulating miRNAs, Small but Promising Biomarkers for Autism Spectrum Disorder |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Autism spectrum disorder (ASD) refers to a heterogeneous group of complex neurodevelopmental disorders characterized by social skill and communication deficits, along with stereotyped repetitive behavior. miRNAs, small non-coding RNAs that have been recognized as critical regulators of gene expression, play a key role in the neurodevelopmental transcriptional networks of the human brain. Previous investigations have proven that circulating miRNAs open up new possibilities for the emerging roles of diagnostic and prognostic biomarkers in human disorders and diseases. Biomarker development has been progressively becoming more recognized as a cornerstone in medical diagnosis, paving the way to drug discoveries and limiting the progression of various diseases. Due to the complexity of ASD, considerable endeavors have either unsuccessfully identified biomarkers for the disorder or have not yet been established. Cell-free circulating miRNAs in biofluids are extraordinarily stable and considered to represent the next-generation of clinical, non-invasive, biomarkers for many pathologies including neurological and neurodevelopmental disorders. Here, we conducted a review of all peer-reviewed articles addressing the circulating profiles of miRNAs, mostly performed in serum and saliva samples in individuals with ASD.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Molecular Neuroscience<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fnmol.2019.00253" target="_blank">https://dx.doi.org/10.3389/fnmol.2019.00253</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_0e0f50d49d75320df7266bd0b26d4e3d |
| identifier_str_mv | 10.3389/fnmol.2019.00253 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25904416 |
| publishDate | 2019 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Circulating miRNAs, Small but Promising Biomarkers for Autism Spectrum DisorderSalam Salloum-Asfar (656363)Noothan J. Satheesh (18615121)Sara A. Abdulla (13902015)Biological sciencesGeneticsBiomedical and clinical sciencesNeurosciencesneurodevelopmental disorderscirculating miRNAbiomarkersAutism Spectrum DisordermicroRNAbiofluid analysis<p dir="ltr">Autism spectrum disorder (ASD) refers to a heterogeneous group of complex neurodevelopmental disorders characterized by social skill and communication deficits, along with stereotyped repetitive behavior. miRNAs, small non-coding RNAs that have been recognized as critical regulators of gene expression, play a key role in the neurodevelopmental transcriptional networks of the human brain. Previous investigations have proven that circulating miRNAs open up new possibilities for the emerging roles of diagnostic and prognostic biomarkers in human disorders and diseases. Biomarker development has been progressively becoming more recognized as a cornerstone in medical diagnosis, paving the way to drug discoveries and limiting the progression of various diseases. Due to the complexity of ASD, considerable endeavors have either unsuccessfully identified biomarkers for the disorder or have not yet been established. Cell-free circulating miRNAs in biofluids are extraordinarily stable and considered to represent the next-generation of clinical, non-invasive, biomarkers for many pathologies including neurological and neurodevelopmental disorders. Here, we conducted a review of all peer-reviewed articles addressing the circulating profiles of miRNAs, mostly performed in serum and saliva samples in individuals with ASD.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Molecular Neuroscience<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fnmol.2019.00253" target="_blank">https://dx.doi.org/10.3389/fnmol.2019.00253</a></p>2019-10-11T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3389/fnmol.2019.00253https://figshare.com/articles/journal_contribution/Circulating_miRNAs_Small_but_Promising_Biomarkers_for_Autism_Spectrum_Disorder/25904416CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/259044162019-10-11T03:00:00Z |
| spellingShingle | Circulating miRNAs, Small but Promising Biomarkers for Autism Spectrum Disorder Salam Salloum-Asfar (656363) Biological sciences Genetics Biomedical and clinical sciences Neurosciences neurodevelopmental disorders circulating miRNA biomarkers Autism Spectrum Disorder microRNA biofluid analysis |
| status_str | publishedVersion |
| title | Circulating miRNAs, Small but Promising Biomarkers for Autism Spectrum Disorder |
| title_full | Circulating miRNAs, Small but Promising Biomarkers for Autism Spectrum Disorder |
| title_fullStr | Circulating miRNAs, Small but Promising Biomarkers for Autism Spectrum Disorder |
| title_full_unstemmed | Circulating miRNAs, Small but Promising Biomarkers for Autism Spectrum Disorder |
| title_short | Circulating miRNAs, Small but Promising Biomarkers for Autism Spectrum Disorder |
| title_sort | Circulating miRNAs, Small but Promising Biomarkers for Autism Spectrum Disorder |
| topic | Biological sciences Genetics Biomedical and clinical sciences Neurosciences neurodevelopmental disorders circulating miRNA biomarkers Autism Spectrum Disorder microRNA biofluid analysis |