Metabolic reprogramming of T regulatory cells in the hypoxic tumor microenvironment
<p dir="ltr">Metabolic dysregulation in the hypoxic tumor microenvironment (TME) is considered as a hallmark of solid tumors, leading to changes in biosynthetic pathways favoring onset, survival and proliferation of malignant cells. Within the TME, hypoxic milieu favors metabolic rep...
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| مؤلفون آخرون: | , , , |
| منشور في: |
2021
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| _version_ | 1864513516838322176 |
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| author | Varun Sasidharan Nair (5396393) |
| author2 | Reem Saleh (3513056) Salman M. Toor (8854751) Farhan S. Cyprian (11924492) Eyad Elkord (5396390) |
| author2_role | author author author author |
| author_facet | Varun Sasidharan Nair (5396393) Reem Saleh (3513056) Salman M. Toor (8854751) Farhan S. Cyprian (11924492) Eyad Elkord (5396390) |
| author_role | author |
| dc.creator.none.fl_str_mv | Varun Sasidharan Nair (5396393) Reem Saleh (3513056) Salman M. Toor (8854751) Farhan S. Cyprian (11924492) Eyad Elkord (5396390) |
| dc.date.none.fl_str_mv | 2021-02-03T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1007/s00262-020-02842-y |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Metabolic_reprogramming_of_T_regulatory_cells_in_the_hypoxic_tumor_microenvironment/25709139 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Oncology and carcinogenesis T regulatory cells Hypoxia Tumor microenvironment Metabolism Glycolysis Fatty acid metabolism |
| dc.title.none.fl_str_mv | Metabolic reprogramming of T regulatory cells in the hypoxic tumor microenvironment |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Metabolic dysregulation in the hypoxic tumor microenvironment (TME) is considered as a hallmark of solid tumors, leading to changes in biosynthetic pathways favoring onset, survival and proliferation of malignant cells. Within the TME, hypoxic milieu favors metabolic reprogramming of tumor cells, which subsequently affects biological properties of tumor-infiltrating immune cells. T regulatory cells (Tregs), including both circulating and tissue-resident cells, are particularly susceptible to hypoxic metabolic signaling that can reprogram their biological and physicochemical properties. Furthermore, metabolic reprogramming modifies Tregs to utilize alternative substrates and undergo a plethora of metabolic events to meet their energy demands. Major impact of this metabolic reprogramming can result in differentiation, survival, excessive secretion of immunosuppressive cytokines and proliferation of Tregs within the TME, which in turn dampen anti-tumor immune responses. Studies on fine-tuning of Treg metabolism are challenging due to heterogenicity of tissue-resident Tregs and their dynamic functions. In this review, we highlight tumor intrinsic and extrinsic factors, which can influence Treg metabolism in the hypoxic TME. Moreover, we focus on metabolic reprogramming of Tregs that could unveil potential regulatory networks favoring tumorigenesis/progression, and provide novel insights, including inhibitors against acetyl-coA carboxylase 1 and transforming growth factor beta into targeting Treg metabolism for therapeutic benefits.</p><p dir="ltr">Correction: Metabolic reprogramming of T regulatory cells in the hypoxic tumor microenvironment. <a href="https://dx.doi.org/10.1007/s00262-021-02999-0" target="_blank">https://dx.doi.org/10.1007/s00262-021-02999-0</a>, published online 07 July 2021.</p><h2>Other Information</h2><p dir="ltr">Published in: Cancer Immunology, Immunotherapy<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s00262-020-02842-y" target="_blank">https://dx.doi.org/10.1007/s00262-020-02842-y</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_0f2995c103c61747b177f7651e551fae |
| identifier_str_mv | 10.1007/s00262-020-02842-y |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25709139 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Metabolic reprogramming of T regulatory cells in the hypoxic tumor microenvironmentVarun Sasidharan Nair (5396393)Reem Saleh (3513056)Salman M. Toor (8854751)Farhan S. Cyprian (11924492)Eyad Elkord (5396390)Biomedical and clinical sciencesOncology and carcinogenesisT regulatory cellsHypoxiaTumor microenvironmentMetabolismGlycolysisFatty acid metabolism<p dir="ltr">Metabolic dysregulation in the hypoxic tumor microenvironment (TME) is considered as a hallmark of solid tumors, leading to changes in biosynthetic pathways favoring onset, survival and proliferation of malignant cells. Within the TME, hypoxic milieu favors metabolic reprogramming of tumor cells, which subsequently affects biological properties of tumor-infiltrating immune cells. T regulatory cells (Tregs), including both circulating and tissue-resident cells, are particularly susceptible to hypoxic metabolic signaling that can reprogram their biological and physicochemical properties. Furthermore, metabolic reprogramming modifies Tregs to utilize alternative substrates and undergo a plethora of metabolic events to meet their energy demands. Major impact of this metabolic reprogramming can result in differentiation, survival, excessive secretion of immunosuppressive cytokines and proliferation of Tregs within the TME, which in turn dampen anti-tumor immune responses. Studies on fine-tuning of Treg metabolism are challenging due to heterogenicity of tissue-resident Tregs and their dynamic functions. In this review, we highlight tumor intrinsic and extrinsic factors, which can influence Treg metabolism in the hypoxic TME. Moreover, we focus on metabolic reprogramming of Tregs that could unveil potential regulatory networks favoring tumorigenesis/progression, and provide novel insights, including inhibitors against acetyl-coA carboxylase 1 and transforming growth factor beta into targeting Treg metabolism for therapeutic benefits.</p><p dir="ltr">Correction: Metabolic reprogramming of T regulatory cells in the hypoxic tumor microenvironment. <a href="https://dx.doi.org/10.1007/s00262-021-02999-0" target="_blank">https://dx.doi.org/10.1007/s00262-021-02999-0</a>, published online 07 July 2021.</p><h2>Other Information</h2><p dir="ltr">Published in: Cancer Immunology, Immunotherapy<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s00262-020-02842-y" target="_blank">https://dx.doi.org/10.1007/s00262-020-02842-y</a></p>2021-02-03T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1007/s00262-020-02842-yhttps://figshare.com/articles/journal_contribution/Metabolic_reprogramming_of_T_regulatory_cells_in_the_hypoxic_tumor_microenvironment/25709139CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/257091392021-02-03T03:00:00Z |
| spellingShingle | Metabolic reprogramming of T regulatory cells in the hypoxic tumor microenvironment Varun Sasidharan Nair (5396393) Biomedical and clinical sciences Oncology and carcinogenesis T regulatory cells Hypoxia Tumor microenvironment Metabolism Glycolysis Fatty acid metabolism |
| status_str | publishedVersion |
| title | Metabolic reprogramming of T regulatory cells in the hypoxic tumor microenvironment |
| title_full | Metabolic reprogramming of T regulatory cells in the hypoxic tumor microenvironment |
| title_fullStr | Metabolic reprogramming of T regulatory cells in the hypoxic tumor microenvironment |
| title_full_unstemmed | Metabolic reprogramming of T regulatory cells in the hypoxic tumor microenvironment |
| title_short | Metabolic reprogramming of T regulatory cells in the hypoxic tumor microenvironment |
| title_sort | Metabolic reprogramming of T regulatory cells in the hypoxic tumor microenvironment |
| topic | Biomedical and clinical sciences Oncology and carcinogenesis T regulatory cells Hypoxia Tumor microenvironment Metabolism Glycolysis Fatty acid metabolism |