AgCuB nanoparticle eradicates intracellular<i> S. aureus</i> infection in bone cells: in vitro
<p dir="ltr"><i>Staphylococcus aureus</i> is the leading cause of internalized bone infection. Internalized bacteria are shielded from the immune system and antibiotics causing complications of conventional antibiotic treatment. In this study, we investigate silver-copper...
محفوظ في:
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| مؤلفون آخرون: | , , , |
| منشور في: |
2019
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| الملخص: | <p dir="ltr"><i>Staphylococcus aureus</i> is the leading cause of internalized bone infection. Internalized bacteria are shielded from the immune system and antibiotics causing complications of conventional antibiotic treatment. In this study, we investigate silver-copper-boron (AgCuB) nanoparticles (NPs) as a potential alternative to eradicate internalized bacterial infection without causing a harming effect on the host cells. The antimicrobial property, as well as the toxicity of the AgCuB NP’s, is reported as dose-dependent between 0 and 20 μg/ml. Our results showed that 1–5 μg/ml of AgCuB NPs significantly reduced internalized infection in osteoblast cells with a single dose of treatment. The host cell toxicity observed at 20 μg/ml is ten times higher than the effective antimicrobial dose.</p><h2>Other Information</h2><p dir="ltr">Published in: Emergent Materials<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1007/s42247-019-00035-7" target="_blank">http://dx.doi.org/10.1007/s42247-019-00035-7</a></p> |
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