AgCuB nanoparticle eradicates intracellular<i> S. aureus</i> infection in bone cells: in vitro
<p dir="ltr"><i>Staphylococcus aureus</i> is the leading cause of internalized bone infection. Internalized bacteria are shielded from the immune system and antibiotics causing complications of conventional antibiotic treatment. In this study, we investigate silver-copper...
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2019
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| _version_ | 1864513552219373568 |
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| author | Shahnaz Qadri (2610634) |
| author2 | Tahir Abdulrehman (8697696) Jamil Azzi (613106) Said Mansour (8697699) Yousef Haik (2610628) |
| author2_role | author author author author |
| author_facet | Shahnaz Qadri (2610634) Tahir Abdulrehman (8697696) Jamil Azzi (613106) Said Mansour (8697699) Yousef Haik (2610628) |
| author_role | author |
| dc.creator.none.fl_str_mv | Shahnaz Qadri (2610634) Tahir Abdulrehman (8697696) Jamil Azzi (613106) Said Mansour (8697699) Yousef Haik (2610628) |
| dc.date.none.fl_str_mv | 2019-07-24T21:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1007/s42247-019-00035-7 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/AgCuB_nanoparticle_eradicates_intracellular_S_aureus_infection_in_bone_cells_in_vitro/21597888 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Microbiology Engineering Nanotechnology Staphylococcus aureus Internalized bone infection Osteomyelitis Silver-copper-boron (AgCuB) nanoparticles Antimicrobial properties |
| dc.title.none.fl_str_mv | AgCuB nanoparticle eradicates intracellular<i> S. aureus</i> infection in bone cells: in vitro |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr"><i>Staphylococcus aureus</i> is the leading cause of internalized bone infection. Internalized bacteria are shielded from the immune system and antibiotics causing complications of conventional antibiotic treatment. In this study, we investigate silver-copper-boron (AgCuB) nanoparticles (NPs) as a potential alternative to eradicate internalized bacterial infection without causing a harming effect on the host cells. The antimicrobial property, as well as the toxicity of the AgCuB NP’s, is reported as dose-dependent between 0 and 20 μg/ml. Our results showed that 1–5 μg/ml of AgCuB NPs significantly reduced internalized infection in osteoblast cells with a single dose of treatment. The host cell toxicity observed at 20 μg/ml is ten times higher than the effective antimicrobial dose.</p><h2>Other Information</h2><p dir="ltr">Published in: Emergent Materials<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1007/s42247-019-00035-7" target="_blank">http://dx.doi.org/10.1007/s42247-019-00035-7</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_0f401d524bffd75a07ce5110fec5542f |
| identifier_str_mv | 10.1007/s42247-019-00035-7 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/21597888 |
| publishDate | 2019 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | AgCuB nanoparticle eradicates intracellular<i> S. aureus</i> infection in bone cells: in vitroShahnaz Qadri (2610634)Tahir Abdulrehman (8697696)Jamil Azzi (613106)Said Mansour (8697699)Yousef Haik (2610628)Biological sciencesMicrobiologyEngineeringNanotechnologyStaphylococcus aureusInternalized bone infectionOsteomyelitisSilver-copper-boron (AgCuB) nanoparticlesAntimicrobial properties<p dir="ltr"><i>Staphylococcus aureus</i> is the leading cause of internalized bone infection. Internalized bacteria are shielded from the immune system and antibiotics causing complications of conventional antibiotic treatment. In this study, we investigate silver-copper-boron (AgCuB) nanoparticles (NPs) as a potential alternative to eradicate internalized bacterial infection without causing a harming effect on the host cells. The antimicrobial property, as well as the toxicity of the AgCuB NP’s, is reported as dose-dependent between 0 and 20 μg/ml. Our results showed that 1–5 μg/ml of AgCuB NPs significantly reduced internalized infection in osteoblast cells with a single dose of treatment. The host cell toxicity observed at 20 μg/ml is ten times higher than the effective antimicrobial dose.</p><h2>Other Information</h2><p dir="ltr">Published in: Emergent Materials<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1007/s42247-019-00035-7" target="_blank">http://dx.doi.org/10.1007/s42247-019-00035-7</a></p>2019-07-24T21:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1007/s42247-019-00035-7https://figshare.com/articles/journal_contribution/AgCuB_nanoparticle_eradicates_intracellular_S_aureus_infection_in_bone_cells_in_vitro/21597888CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/215978882019-07-24T21:00:00Z |
| spellingShingle | AgCuB nanoparticle eradicates intracellular<i> S. aureus</i> infection in bone cells: in vitro Shahnaz Qadri (2610634) Biological sciences Microbiology Engineering Nanotechnology Staphylococcus aureus Internalized bone infection Osteomyelitis Silver-copper-boron (AgCuB) nanoparticles Antimicrobial properties |
| status_str | publishedVersion |
| title | AgCuB nanoparticle eradicates intracellular<i> S. aureus</i> infection in bone cells: in vitro |
| title_full | AgCuB nanoparticle eradicates intracellular<i> S. aureus</i> infection in bone cells: in vitro |
| title_fullStr | AgCuB nanoparticle eradicates intracellular<i> S. aureus</i> infection in bone cells: in vitro |
| title_full_unstemmed | AgCuB nanoparticle eradicates intracellular<i> S. aureus</i> infection in bone cells: in vitro |
| title_short | AgCuB nanoparticle eradicates intracellular<i> S. aureus</i> infection in bone cells: in vitro |
| title_sort | AgCuB nanoparticle eradicates intracellular<i> S. aureus</i> infection in bone cells: in vitro |
| topic | Biological sciences Microbiology Engineering Nanotechnology Staphylococcus aureus Internalized bone infection Osteomyelitis Silver-copper-boron (AgCuB) nanoparticles Antimicrobial properties |