A systematic review and meta-analysis on the impact of early vs. delayed pharmacological thromboprophylaxis in patients with traumatic brain injury
<h3>Background </h3><p dir="ltr">Traumatic brain injury (TBI) poses significant health challenges, often leading to complications such as venous thromboembolism (VTE) and increased mortality rates. The administration of early post-traumatic prophylaxis (PTP) is intended t...
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| مؤلفون آخرون: | , , , , , , , , , , , , , , |
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2024
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إضافة وسم
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| _version_ | 1864513552665018368 |
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| author | Muhammad Hamza Shuja (19748620) |
| author2 | Muhammad Moiz Nasir (19181168) Hasan Mushahid (20484248) Adam Bilal Khan (20484251) Javed Iqbal (2121922) Afia Jawaid (20484254) Syed Husain Farhan (20484257) Fakhar Latif (19760906) Muhammad Ayyan (16328986) Minaam Farooq (11740022) Jawad Ahmed (5873762) Huzaifa Ul Haq Ansari (20484260) Unzela Iqbal (20484263) Sobia Mansoor (20484266) Syed Ali Farhan (20484269) Muhammad Mubariz (19181165) |
| author2_role | author author author author author author author author author author author author author author author |
| author_facet | Muhammad Hamza Shuja (19748620) Muhammad Moiz Nasir (19181168) Hasan Mushahid (20484248) Adam Bilal Khan (20484251) Javed Iqbal (2121922) Afia Jawaid (20484254) Syed Husain Farhan (20484257) Fakhar Latif (19760906) Muhammad Ayyan (16328986) Minaam Farooq (11740022) Jawad Ahmed (5873762) Huzaifa Ul Haq Ansari (20484260) Unzela Iqbal (20484263) Sobia Mansoor (20484266) Syed Ali Farhan (20484269) Muhammad Mubariz (19181165) |
| author_role | author |
| dc.creator.none.fl_str_mv | Muhammad Hamza Shuja (19748620) Muhammad Moiz Nasir (19181168) Hasan Mushahid (20484248) Adam Bilal Khan (20484251) Javed Iqbal (2121922) Afia Jawaid (20484254) Syed Husain Farhan (20484257) Fakhar Latif (19760906) Muhammad Ayyan (16328986) Minaam Farooq (11740022) Jawad Ahmed (5873762) Huzaifa Ul Haq Ansari (20484260) Unzela Iqbal (20484263) Sobia Mansoor (20484266) Syed Ali Farhan (20484269) Muhammad Mubariz (19181165) |
| dc.date.none.fl_str_mv | 2024-12-10T18:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.jocn.2024.110936 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/A_systematic_review_and_meta-analysis_on_the_impact_of_early_vs_delayed_pharmacological_thromboprophylaxis_in_patients_with_traumatic_brain_injury/28107170 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Neurosciences Pharmacology and pharmaceutical sciences Traumatic brain injury Venous thromboembolism Pharmacologic thromboprophylaxis Deep vein thrombosis Pulmonary embolism Early prophylaxis Mortality |
| dc.title.none.fl_str_mv | A systematic review and meta-analysis on the impact of early vs. delayed pharmacological thromboprophylaxis in patients with traumatic brain injury |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background </h3><p dir="ltr">Traumatic brain injury (TBI) poses significant health challenges, often leading to complications such as venous thromboembolism (VTE) and increased mortality rates. The administration of early post-traumatic prophylaxis (PTP) is intended to mitigate these risks and enhance overall patient recovery. This study aims to perform a systematic review and <i>meta</i>-analysis assessing clinical outcomes associated with early versus late pharmacologic thromboprophylaxis in TBI patients. </p><h3>Methods </h3><p dir="ltr">We conducted a literature search across PubMed and Scopus databases from their inception to March 2024. Data from eligible studies were aggregated using the generic inverse variance method, with outcomes reported as odds ratios (OR). </p><h3>Results </h3><p dir="ltr">The review encompassed 20 studies involving 87,726 patients. Early PTP was categorized based on the timing of administration: 1) within 24 h, 2) within 48 h, and 3) within 72 h of hospital admission. Our findings indicated that early prophylaxis significantly reduced the incidence of VTE, deep vein thrombosis (DVT), pulmonary embolism (PE), and overall mortality when compared to late administration. Specifically, early PTP was associated with a markedly lower risk of VTE (OR: 0.38; 95 % CI: 0.30 to 0.48; P < 0.00001), DVT (OR: 0.32; 95 % CI: 0.25 to 0.41; P < 0.00001), and PE (OR: 0.39; 95 % CI: 0.31 to 0.49; P < 0.00001). Furthermore, the analysis revealed a significant reduction in all-cause mortality within the early PTP group (OR: 0.71; 95 % CI: 0.53 to 0.97; P = 0.03). However, while statistically significant improvements were observed in the <48-hour subgroup, neither the <24-hour nor <72-hour groups achieved statistical significance. </p><h3>Conclusion </h3><p dir="ltr">These robust findings highlight the potential of early pharmacologic thromboprophylaxis as a crucial intervention to enhance patient outcomes following traumatic brain injuries.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Clinical Neuroscience<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.jocn.2024.110936" target="_blank">https://dx.doi.org/10.1016/j.jocn.2024.110936</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_0fe56faa0ad77c236622dbfe9a892204 |
| identifier_str_mv | 10.1016/j.jocn.2024.110936 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/28107170 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | A systematic review and meta-analysis on the impact of early vs. delayed pharmacological thromboprophylaxis in patients with traumatic brain injuryMuhammad Hamza Shuja (19748620)Muhammad Moiz Nasir (19181168)Hasan Mushahid (20484248)Adam Bilal Khan (20484251)Javed Iqbal (2121922)Afia Jawaid (20484254)Syed Husain Farhan (20484257)Fakhar Latif (19760906)Muhammad Ayyan (16328986)Minaam Farooq (11740022)Jawad Ahmed (5873762)Huzaifa Ul Haq Ansari (20484260)Unzela Iqbal (20484263)Sobia Mansoor (20484266)Syed Ali Farhan (20484269)Muhammad Mubariz (19181165)Biomedical and clinical sciencesCardiovascular medicine and haematologyNeurosciencesPharmacology and pharmaceutical sciencesTraumatic brain injuryVenous thromboembolismPharmacologic thromboprophylaxisDeep vein thrombosisPulmonary embolismEarly prophylaxisMortality<h3>Background </h3><p dir="ltr">Traumatic brain injury (TBI) poses significant health challenges, often leading to complications such as venous thromboembolism (VTE) and increased mortality rates. The administration of early post-traumatic prophylaxis (PTP) is intended to mitigate these risks and enhance overall patient recovery. This study aims to perform a systematic review and <i>meta</i>-analysis assessing clinical outcomes associated with early versus late pharmacologic thromboprophylaxis in TBI patients. </p><h3>Methods </h3><p dir="ltr">We conducted a literature search across PubMed and Scopus databases from their inception to March 2024. Data from eligible studies were aggregated using the generic inverse variance method, with outcomes reported as odds ratios (OR). </p><h3>Results </h3><p dir="ltr">The review encompassed 20 studies involving 87,726 patients. Early PTP was categorized based on the timing of administration: 1) within 24 h, 2) within 48 h, and 3) within 72 h of hospital admission. Our findings indicated that early prophylaxis significantly reduced the incidence of VTE, deep vein thrombosis (DVT), pulmonary embolism (PE), and overall mortality when compared to late administration. Specifically, early PTP was associated with a markedly lower risk of VTE (OR: 0.38; 95 % CI: 0.30 to 0.48; P < 0.00001), DVT (OR: 0.32; 95 % CI: 0.25 to 0.41; P < 0.00001), and PE (OR: 0.39; 95 % CI: 0.31 to 0.49; P < 0.00001). Furthermore, the analysis revealed a significant reduction in all-cause mortality within the early PTP group (OR: 0.71; 95 % CI: 0.53 to 0.97; P = 0.03). However, while statistically significant improvements were observed in the <48-hour subgroup, neither the <24-hour nor <72-hour groups achieved statistical significance. </p><h3>Conclusion </h3><p dir="ltr">These robust findings highlight the potential of early pharmacologic thromboprophylaxis as a crucial intervention to enhance patient outcomes following traumatic brain injuries.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Clinical Neuroscience<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.jocn.2024.110936" target="_blank">https://dx.doi.org/10.1016/j.jocn.2024.110936</a></p>2024-12-10T18:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.jocn.2024.110936https://figshare.com/articles/journal_contribution/A_systematic_review_and_meta-analysis_on_the_impact_of_early_vs_delayed_pharmacological_thromboprophylaxis_in_patients_with_traumatic_brain_injury/28107170CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/281071702024-12-10T18:00:00Z |
| spellingShingle | A systematic review and meta-analysis on the impact of early vs. delayed pharmacological thromboprophylaxis in patients with traumatic brain injury Muhammad Hamza Shuja (19748620) Biomedical and clinical sciences Cardiovascular medicine and haematology Neurosciences Pharmacology and pharmaceutical sciences Traumatic brain injury Venous thromboembolism Pharmacologic thromboprophylaxis Deep vein thrombosis Pulmonary embolism Early prophylaxis Mortality |
| status_str | publishedVersion |
| title | A systematic review and meta-analysis on the impact of early vs. delayed pharmacological thromboprophylaxis in patients with traumatic brain injury |
| title_full | A systematic review and meta-analysis on the impact of early vs. delayed pharmacological thromboprophylaxis in patients with traumatic brain injury |
| title_fullStr | A systematic review and meta-analysis on the impact of early vs. delayed pharmacological thromboprophylaxis in patients with traumatic brain injury |
| title_full_unstemmed | A systematic review and meta-analysis on the impact of early vs. delayed pharmacological thromboprophylaxis in patients with traumatic brain injury |
| title_short | A systematic review and meta-analysis on the impact of early vs. delayed pharmacological thromboprophylaxis in patients with traumatic brain injury |
| title_sort | A systematic review and meta-analysis on the impact of early vs. delayed pharmacological thromboprophylaxis in patients with traumatic brain injury |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Neurosciences Pharmacology and pharmaceutical sciences Traumatic brain injury Venous thromboembolism Pharmacologic thromboprophylaxis Deep vein thrombosis Pulmonary embolism Early prophylaxis Mortality |