Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance
<p>Early-stage detection of leukemia is a critical determinant for successful treatment of the disease and can increase the survival rate of leukemia patients. The factors limiting the current screening approaches to leukemia include low sensitivity and specificity, high costs, and a low parti...
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2022
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| _version_ | 1864513566595350528 |
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| author | Ajaz A. Bhat (12984701) |
| author2 | Salma N. Younes (14153241) Syed Shadab Raza (5775911) Lubna Zarif (14152344) Sabah Nisar (12561961) Ikhlak Ahmed (150200) Rashid Mir (2616949) Sachin Kumar (356188) Surender K. Sharawat (12176110) Sheema Hashem (14150961) Imadeldin Elfaki (14153244) Michal Kulinski (3520070) Shilpa Kuttikrishnan (3520079) Kirti S. Prabhu (4246144) Abdul Q. Khan (14153247) Santosh K. Yadav (9364664) Wael El-Rifai (303374) Mohammad A. Zargar (14153250) Hatem Zayed (835448) Mohammad Haris (564809) Shahab Uddin (14150949) |
| author2_role | author author author author author author author author author author author author author author author author author author author author |
| author_facet | Ajaz A. Bhat (12984701) Salma N. Younes (14153241) Syed Shadab Raza (5775911) Lubna Zarif (14152344) Sabah Nisar (12561961) Ikhlak Ahmed (150200) Rashid Mir (2616949) Sachin Kumar (356188) Surender K. Sharawat (12176110) Sheema Hashem (14150961) Imadeldin Elfaki (14153244) Michal Kulinski (3520070) Shilpa Kuttikrishnan (3520079) Kirti S. Prabhu (4246144) Abdul Q. Khan (14153247) Santosh K. Yadav (9364664) Wael El-Rifai (303374) Mohammad A. Zargar (14153250) Hatem Zayed (835448) Mohammad Haris (564809) Shahab Uddin (14150949) |
| author_role | author |
| dc.creator.none.fl_str_mv | Ajaz A. Bhat (12984701) Salma N. Younes (14153241) Syed Shadab Raza (5775911) Lubna Zarif (14152344) Sabah Nisar (12561961) Ikhlak Ahmed (150200) Rashid Mir (2616949) Sachin Kumar (356188) Surender K. Sharawat (12176110) Sheema Hashem (14150961) Imadeldin Elfaki (14153244) Michal Kulinski (3520070) Shilpa Kuttikrishnan (3520079) Kirti S. Prabhu (4246144) Abdul Q. Khan (14153247) Santosh K. Yadav (9364664) Wael El-Rifai (303374) Mohammad A. Zargar (14153250) Hatem Zayed (835448) Mohammad Haris (564809) Shahab Uddin (14150949) |
| dc.date.none.fl_str_mv | 2022-11-22T21:18:01Z |
| dc.identifier.none.fl_str_mv | 10.1186/s12943-020-01175-9 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Role_of_non-coding_RNA_networks_in_leukemia_progression_metastasis_and_drug_resistance/21598428 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Genetics Biomedical and clinical sciences Oncology and carcinogenesis Cancer Circular RNAs Chromatin Drug resistance Epigenetics Gene regulation Long non-coding RNAs MicroRNAs Metastasis Signaling pathways |
| dc.title.none.fl_str_mv | Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p>Early-stage detection of leukemia is a critical determinant for successful treatment of the disease and can increase the survival rate of leukemia patients. The factors limiting the current screening approaches to leukemia include low sensitivity and specificity, high costs, and a low participation rate. An approach based on novel and innovative biomarkers with high accuracy from peripheral blood offers a comfortable and appealing alternative to patients, potentially leading to a higher participation rate.</p> <p>Recently, non-coding RNAs due to their involvement in vital oncogenic processes such as differentiation, proliferation, migration, angiogenesis and apoptosis have attracted much attention as potential diagnostic and prognostic biomarkers in leukemia. Emerging lines of evidence have shown that the mutational spectrum and dysregulated expression of non-coding RNA genes are closely associated with the development and progression of various cancers, including leukemia. In this review, we highlight the expression and functional roles of different types of non-coding RNAs in leukemia and discuss their potential clinical applications as diagnostic or prognostic biomarkers and therapeutic targets.</p><h2>Other Information</h2> <p> Published in: Molecular Cancer<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1186/s12943-020-01175-9" target="_blank">http://dx.doi.org/10.1186/s12943-020-01175-9</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_0febd6324240a42adb43f844bb5657eb |
| identifier_str_mv | 10.1186/s12943-020-01175-9 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/21598428 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Role of non-coding RNA networks in leukemia progression, metastasis and drug resistanceAjaz A. Bhat (12984701)Salma N. Younes (14153241)Syed Shadab Raza (5775911)Lubna Zarif (14152344)Sabah Nisar (12561961)Ikhlak Ahmed (150200)Rashid Mir (2616949)Sachin Kumar (356188)Surender K. Sharawat (12176110)Sheema Hashem (14150961)Imadeldin Elfaki (14153244)Michal Kulinski (3520070)Shilpa Kuttikrishnan (3520079)Kirti S. Prabhu (4246144)Abdul Q. Khan (14153247)Santosh K. Yadav (9364664)Wael El-Rifai (303374)Mohammad A. Zargar (14153250)Hatem Zayed (835448)Mohammad Haris (564809)Shahab Uddin (14150949)Biological sciencesGeneticsBiomedical and clinical sciencesOncology and carcinogenesisCancerCircular RNAsChromatinDrug resistanceEpigeneticsGene regulationLong non-codingRNAsMicroRNAsMetastasisSignaling pathways<p>Early-stage detection of leukemia is a critical determinant for successful treatment of the disease and can increase the survival rate of leukemia patients. The factors limiting the current screening approaches to leukemia include low sensitivity and specificity, high costs, and a low participation rate. An approach based on novel and innovative biomarkers with high accuracy from peripheral blood offers a comfortable and appealing alternative to patients, potentially leading to a higher participation rate.</p> <p>Recently, non-coding RNAs due to their involvement in vital oncogenic processes such as differentiation, proliferation, migration, angiogenesis and apoptosis have attracted much attention as potential diagnostic and prognostic biomarkers in leukemia. Emerging lines of evidence have shown that the mutational spectrum and dysregulated expression of non-coding RNA genes are closely associated with the development and progression of various cancers, including leukemia. In this review, we highlight the expression and functional roles of different types of non-coding RNAs in leukemia and discuss their potential clinical applications as diagnostic or prognostic biomarkers and therapeutic targets.</p><h2>Other Information</h2> <p> Published in: Molecular Cancer<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1186/s12943-020-01175-9" target="_blank">http://dx.doi.org/10.1186/s12943-020-01175-9</a></p>2022-11-22T21:18:01ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1186/s12943-020-01175-9https://figshare.com/articles/journal_contribution/Role_of_non-coding_RNA_networks_in_leukemia_progression_metastasis_and_drug_resistance/21598428CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/215984282022-11-22T21:18:01Z |
| spellingShingle | Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance Ajaz A. Bhat (12984701) Biological sciences Genetics Biomedical and clinical sciences Oncology and carcinogenesis Cancer Circular RNAs Chromatin Drug resistance Epigenetics Gene regulation Long non-coding RNAs MicroRNAs Metastasis Signaling pathways |
| status_str | publishedVersion |
| title | Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance |
| title_full | Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance |
| title_fullStr | Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance |
| title_full_unstemmed | Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance |
| title_short | Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance |
| title_sort | Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance |
| topic | Biological sciences Genetics Biomedical and clinical sciences Oncology and carcinogenesis Cancer Circular RNAs Chromatin Drug resistance Epigenetics Gene regulation Long non-coding RNAs MicroRNAs Metastasis Signaling pathways |