Osteopontin: A Promising Therapeutic Target in Cardiac Fibrosis
<div><p>Osteopontin (OPN) is recognized for its significant roles in both physiological and pathological processes. Initially, OPN was recognized as a cytokine with pro-inflammatory actions. More recently, OPN has emerged as a matricellular protein of the extracellular matrix (ECM). OPN...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | , , , |
| Published: |
2019
|
| Subjects: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1864513525395750912 |
|---|---|
| author | Iman Abdelaziz Mohamed (18102700) |
| author2 | Alain-Pierre Gadeau (490299) Anwarul Hasan (1332066) Nabeel Abdulrahman (725914) Fatima Mraiche (715733) |
| author2_role | author author author author |
| author_facet | Iman Abdelaziz Mohamed (18102700) Alain-Pierre Gadeau (490299) Anwarul Hasan (1332066) Nabeel Abdulrahman (725914) Fatima Mraiche (715733) |
| author_role | author |
| dc.creator.none.fl_str_mv | Iman Abdelaziz Mohamed (18102700) Alain-Pierre Gadeau (490299) Anwarul Hasan (1332066) Nabeel Abdulrahman (725914) Fatima Mraiche (715733) |
| dc.date.none.fl_str_mv | 2019-12-03T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/cells8121558 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Osteopontin_A_Promising_Therapeutic_Target_in_Cardiac_Fibrosis/25340392 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology osteopontin inflammation cardiac fibrosis potential therapeutic target biomarker |
| dc.title.none.fl_str_mv | Osteopontin: A Promising Therapeutic Target in Cardiac Fibrosis |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <div><p>Osteopontin (OPN) is recognized for its significant roles in both physiological and pathological processes. Initially, OPN was recognized as a cytokine with pro-inflammatory actions. More recently, OPN has emerged as a matricellular protein of the extracellular matrix (ECM). OPN is also known to be a substrate for proteolytic cleavage by several proteases that form an integral part of the ECM. In the adult heart under physiological conditions, basal levels of OPN are expressed. Increased expression of OPN has been correlated with the progression of cardiac remodeling and fibrosis to heart failure and the severity of the condition. The intricate process by which OPN mediates its effects include the coordination of intracellular signals necessary for the differentiation of fibroblasts into myofibroblasts, promoting angiogenesis, wound healing, and tissue regeneration. In this review, we discuss the role of OPN in contributing to the development of cardiac fibrosis and its suitability as a therapeutic target.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Cells<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/cells8121558" target="_blank">https://dx.doi.org/10.3390/cells8121558</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_1000be8e4adea5f8be90f8622df9ccc1 |
| identifier_str_mv | 10.3390/cells8121558 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25340392 |
| publishDate | 2019 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Osteopontin: A Promising Therapeutic Target in Cardiac FibrosisIman Abdelaziz Mohamed (18102700)Alain-Pierre Gadeau (490299)Anwarul Hasan (1332066)Nabeel Abdulrahman (725914)Fatima Mraiche (715733)Biomedical and clinical sciencesCardiovascular medicine and haematologyosteopontininflammationcardiac fibrosispotential therapeutic targetbiomarker<div><p>Osteopontin (OPN) is recognized for its significant roles in both physiological and pathological processes. Initially, OPN was recognized as a cytokine with pro-inflammatory actions. More recently, OPN has emerged as a matricellular protein of the extracellular matrix (ECM). OPN is also known to be a substrate for proteolytic cleavage by several proteases that form an integral part of the ECM. In the adult heart under physiological conditions, basal levels of OPN are expressed. Increased expression of OPN has been correlated with the progression of cardiac remodeling and fibrosis to heart failure and the severity of the condition. The intricate process by which OPN mediates its effects include the coordination of intracellular signals necessary for the differentiation of fibroblasts into myofibroblasts, promoting angiogenesis, wound healing, and tissue regeneration. In this review, we discuss the role of OPN in contributing to the development of cardiac fibrosis and its suitability as a therapeutic target.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Cells<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/cells8121558" target="_blank">https://dx.doi.org/10.3390/cells8121558</a></p>2019-12-03T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/cells8121558https://figshare.com/articles/journal_contribution/Osteopontin_A_Promising_Therapeutic_Target_in_Cardiac_Fibrosis/25340392CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/253403922019-12-03T03:00:00Z |
| spellingShingle | Osteopontin: A Promising Therapeutic Target in Cardiac Fibrosis Iman Abdelaziz Mohamed (18102700) Biomedical and clinical sciences Cardiovascular medicine and haematology osteopontin inflammation cardiac fibrosis potential therapeutic target biomarker |
| status_str | publishedVersion |
| title | Osteopontin: A Promising Therapeutic Target in Cardiac Fibrosis |
| title_full | Osteopontin: A Promising Therapeutic Target in Cardiac Fibrosis |
| title_fullStr | Osteopontin: A Promising Therapeutic Target in Cardiac Fibrosis |
| title_full_unstemmed | Osteopontin: A Promising Therapeutic Target in Cardiac Fibrosis |
| title_short | Osteopontin: A Promising Therapeutic Target in Cardiac Fibrosis |
| title_sort | Osteopontin: A Promising Therapeutic Target in Cardiac Fibrosis |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology osteopontin inflammation cardiac fibrosis potential therapeutic target biomarker |