Review of the Efficacy and Safety of Dinoprostone “Insert”, “Gel”, and “Tablets” for Cervical Ripening and Induction of Labor
<h3>Introduction</h3><p dir="ltr">Cervical ripening and induction of labor are common obstetric interventions used to manage pregnancies that have reached or exceeded their due dates, have fetal or maternal complications, or for other medical reasons. Prostaglandins are c...
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2023
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| author | Yehia Elkhawly (17039088) |
| author2 | Gulsanga Afridi (17045431) Lolwa Alansari (14777833) Yasmeen Kayani (17039097) Rawan Al-Saleh (17045434) Rohini Puttegowda (17045436) Abdulbasit Almasalmeh (17045438) Naji Abdallah (17045440) Sara Rabaoui (17045456) Morounfolu Thompson (17045472) Eman Alhmoud (13955766) Rasha El Enany (13955781) Zeena Martis (17039087) Ghada Munir (17039094) Tamara Salama (17039093) Salwa Al Rawaili (17039091) |
| author2_role | author author author author author author author author author author author author author author author |
| author_facet | Yehia Elkhawly (17039088) Gulsanga Afridi (17045431) Lolwa Alansari (14777833) Yasmeen Kayani (17039097) Rawan Al-Saleh (17045434) Rohini Puttegowda (17045436) Abdulbasit Almasalmeh (17045438) Naji Abdallah (17045440) Sara Rabaoui (17045456) Morounfolu Thompson (17045472) Eman Alhmoud (13955766) Rasha El Enany (13955781) Zeena Martis (17039087) Ghada Munir (17039094) Tamara Salama (17039093) Salwa Al Rawaili (17039091) |
| author_role | author |
| dc.creator.none.fl_str_mv | Yehia Elkhawly (17039088) Gulsanga Afridi (17045431) Lolwa Alansari (14777833) Yasmeen Kayani (17039097) Rawan Al-Saleh (17045434) Rohini Puttegowda (17045436) Abdulbasit Almasalmeh (17045438) Naji Abdallah (17045440) Sara Rabaoui (17045456) Morounfolu Thompson (17045472) Eman Alhmoud (13955766) Rasha El Enany (13955781) Zeena Martis (17039087) Ghada Munir (17039094) Tamara Salama (17039093) Salwa Al Rawaili (17039091) |
| dc.date.none.fl_str_mv | 2023-10-12T06:51:10Z |
| dc.identifier.none.fl_str_mv | 10.57945/manara.24190953.v1 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/poster/Review_of_the_Efficacy_and_Safety_of_Dinoprostone_Insert_Gel_and_Tablets_for_Cervical_Ripening_and_Induction_of_Labor/24190953 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Pharmacology and pharmaceutical sciences Reproductive medicine Health sciences Nursing Dinoprostone Cervical Ripening |
| dc.title.none.fl_str_mv | Review of the Efficacy and Safety of Dinoprostone “Insert”, “Gel”, and “Tablets” for Cervical Ripening and Induction of Labor |
| dc.type.none.fl_str_mv | Image Poster info:eu-repo/semantics/publishedVersion image |
| description | <h3>Introduction</h3><p dir="ltr">Cervical ripening and induction of labor are common obstetric interventions used to manage pregnancies that have reached or exceeded their due dates, have fetal or maternal complications, or for other medical reasons. Prostaglandins are commonly used for cervical ripening and induction of labor due to their ability to soften and efface the cervix, promote contractions, and facilitate vaginal delivery. Dinoprostone is a synthetic prostaglandin E2 analogue that is available in various formulations, including insert, gel, and tablets. However, there is limited research comparing the efficacy and safety of these different formulations.</p><h3>Methods</h3><p dir="ltr">We conducted a retrospective analysis of 181 women who underwent cervical ripening and induction of labor with dinoprostone insert (n=62), gel (n=76), or tablets (n=43) at our hospital. We collected data on patient characteristics, including age, body mass index (BMI), parity, gestational age, initial Bishop score, and indication for induction.</p><p dir="ltr">Descriptive statistics, including means, standard deviations, and frequencies, were used to evaluate patient characteristics, change in Bishop score, complications, type of birth, time to vaginal delivery, and neonatal outcomes.</p><h3>Results</h3><p dir="ltr">The end bishop score was significantly higher in the insert group (8.32±2.24) compared to the gel (7.2±1.97) and tablet (6.72 ±1.25) groups. Fetal distress and maternal complications were low and similar among the three groups, except for tachysystole, which was more common in the insert group. The time to vaginal delivery was shortest in the tablet group (median=16 hours). Vaginal delivery was the most common mode of delivery in all three groups. Neonatal outcomes were similar among the three groups, except for a higher rate of NICU admission in the gel group.</p><h3>Conclusion</h3><p dir="ltr">The results of this study suggest that all three forms of dinoprostone are effective and safe for cervical ripening. However, the insert form showed a higher bishop score and a higher incidence of tachysystole, while the tablet form showed a shorter time to vaginal delivery. The gel form had a higher rate of NICU admission. These findings can help clinicians choose the most appropriate form of dinoprostone based on individual patient characteristics and preferences. Further prospective studies are needed to confirm these findings.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_12b53f96ebd869c4a993acc48d1c848f |
| identifier_str_mv | 10.57945/manara.24190953.v1 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24190953 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Review of the Efficacy and Safety of Dinoprostone “Insert”, “Gel”, and “Tablets” for Cervical Ripening and Induction of LaborYehia Elkhawly (17039088)Gulsanga Afridi (17045431)Lolwa Alansari (14777833)Yasmeen Kayani (17039097)Rawan Al-Saleh (17045434)Rohini Puttegowda (17045436)Abdulbasit Almasalmeh (17045438)Naji Abdallah (17045440)Sara Rabaoui (17045456)Morounfolu Thompson (17045472)Eman Alhmoud (13955766)Rasha El Enany (13955781)Zeena Martis (17039087)Ghada Munir (17039094)Tamara Salama (17039093)Salwa Al Rawaili (17039091)Biomedical and clinical sciencesPharmacology and pharmaceutical sciencesReproductive medicineHealth sciencesNursingDinoprostoneCervical Ripening<h3>Introduction</h3><p dir="ltr">Cervical ripening and induction of labor are common obstetric interventions used to manage pregnancies that have reached or exceeded their due dates, have fetal or maternal complications, or for other medical reasons. Prostaglandins are commonly used for cervical ripening and induction of labor due to their ability to soften and efface the cervix, promote contractions, and facilitate vaginal delivery. Dinoprostone is a synthetic prostaglandin E2 analogue that is available in various formulations, including insert, gel, and tablets. However, there is limited research comparing the efficacy and safety of these different formulations.</p><h3>Methods</h3><p dir="ltr">We conducted a retrospective analysis of 181 women who underwent cervical ripening and induction of labor with dinoprostone insert (n=62), gel (n=76), or tablets (n=43) at our hospital. We collected data on patient characteristics, including age, body mass index (BMI), parity, gestational age, initial Bishop score, and indication for induction.</p><p dir="ltr">Descriptive statistics, including means, standard deviations, and frequencies, were used to evaluate patient characteristics, change in Bishop score, complications, type of birth, time to vaginal delivery, and neonatal outcomes.</p><h3>Results</h3><p dir="ltr">The end bishop score was significantly higher in the insert group (8.32±2.24) compared to the gel (7.2±1.97) and tablet (6.72 ±1.25) groups. Fetal distress and maternal complications were low and similar among the three groups, except for tachysystole, which was more common in the insert group. The time to vaginal delivery was shortest in the tablet group (median=16 hours). Vaginal delivery was the most common mode of delivery in all three groups. Neonatal outcomes were similar among the three groups, except for a higher rate of NICU admission in the gel group.</p><h3>Conclusion</h3><p dir="ltr">The results of this study suggest that all three forms of dinoprostone are effective and safe for cervical ripening. However, the insert form showed a higher bishop score and a higher incidence of tachysystole, while the tablet form showed a shorter time to vaginal delivery. The gel form had a higher rate of NICU admission. These findings can help clinicians choose the most appropriate form of dinoprostone based on individual patient characteristics and preferences. Further prospective studies are needed to confirm these findings.</p>2023-10-12T06:51:10ZImagePosterinfo:eu-repo/semantics/publishedVersionimage10.57945/manara.24190953.v1https://figshare.com/articles/poster/Review_of_the_Efficacy_and_Safety_of_Dinoprostone_Insert_Gel_and_Tablets_for_Cervical_Ripening_and_Induction_of_Labor/24190953CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/241909532023-10-12T06:51:10Z |
| spellingShingle | Review of the Efficacy and Safety of Dinoprostone “Insert”, “Gel”, and “Tablets” for Cervical Ripening and Induction of Labor Yehia Elkhawly (17039088) Biomedical and clinical sciences Pharmacology and pharmaceutical sciences Reproductive medicine Health sciences Nursing Dinoprostone Cervical Ripening |
| status_str | publishedVersion |
| title | Review of the Efficacy and Safety of Dinoprostone “Insert”, “Gel”, and “Tablets” for Cervical Ripening and Induction of Labor |
| title_full | Review of the Efficacy and Safety of Dinoprostone “Insert”, “Gel”, and “Tablets” for Cervical Ripening and Induction of Labor |
| title_fullStr | Review of the Efficacy and Safety of Dinoprostone “Insert”, “Gel”, and “Tablets” for Cervical Ripening and Induction of Labor |
| title_full_unstemmed | Review of the Efficacy and Safety of Dinoprostone “Insert”, “Gel”, and “Tablets” for Cervical Ripening and Induction of Labor |
| title_short | Review of the Efficacy and Safety of Dinoprostone “Insert”, “Gel”, and “Tablets” for Cervical Ripening and Induction of Labor |
| title_sort | Review of the Efficacy and Safety of Dinoprostone “Insert”, “Gel”, and “Tablets” for Cervical Ripening and Induction of Labor |
| topic | Biomedical and clinical sciences Pharmacology and pharmaceutical sciences Reproductive medicine Health sciences Nursing Dinoprostone Cervical Ripening |