Paving the Way toward Personalized Medicine: Current Advances and Challenges in Multi-OMICS Approach in Autism Spectrum Disorder for Biomarkers Discovery and Patient Stratification
<div><p>Autism spectrum disorder (ASD) is a multifactorial neurodevelopmental disorder characterized by impairments in two main areas: social/communication skills and repetitive behavioral patterns. The prevalence of ASD has increased in the past two decades, however, it is not known whe...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , |
| منشور في: |
2021
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| _version_ | 1864513516598198272 |
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| author | Areej G. Mesleh (18520065) |
| author2 | Sara A. Abdulla (13902015) Omar El-Agnaf (2134222) |
| author2_role | author author |
| author_facet | Areej G. Mesleh (18520065) Sara A. Abdulla (13902015) Omar El-Agnaf (2134222) |
| author_role | author |
| dc.creator.none.fl_str_mv | Areej G. Mesleh (18520065) Sara A. Abdulla (13902015) Omar El-Agnaf (2134222) |
| dc.date.none.fl_str_mv | 2021-01-13T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/jpm11010041 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Paving_the_Way_toward_Personalized_Medicine_Current_Advances_and_Challenges_in_Multi-OMICS_Approach_in_Autism_Spectrum_Disorder_for_Biomarkers_Discovery_and_Patient_Stratification/25771995 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Neurosciences autism spectrum disorder biomarker omics precision medicine proteomics transcriptomics epigenetics metabolomics patient stratification |
| dc.title.none.fl_str_mv | Paving the Way toward Personalized Medicine: Current Advances and Challenges in Multi-OMICS Approach in Autism Spectrum Disorder for Biomarkers Discovery and Patient Stratification |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <div><p>Autism spectrum disorder (ASD) is a multifactorial neurodevelopmental disorder characterized by impairments in two main areas: social/communication skills and repetitive behavioral patterns. The prevalence of ASD has increased in the past two decades, however, it is not known whether the evident rise in ASD prevalence is due to changes in diagnostic criteria or an actual increase in ASD cases. Due to the complexity and heterogeneity of ASD, symptoms vary in severity and may be accompanied by comorbidities such as epilepsy, attention deficit hyperactivity disorder (ADHD), and gastrointestinal (GI) disorders. Identifying biomarkers of ASD is not only crucial to understanding the biological characteristics of the disorder, but also as a detection tool for its early screening. Hence, this review gives an insight into the main areas of ASD biomarker research that show promising findings. Finally, it covers success stories that highlight the importance of precision medicine and the current challenges in ASD biomarker discovery studies.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Journal of Personalized Medicine<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/jpm11010041" target="_blank">https://dx.doi.org/10.3390/jpm11010041</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_132b0f65cd839e03cf7500da9b195ede |
| identifier_str_mv | 10.3390/jpm11010041 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25771995 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Paving the Way toward Personalized Medicine: Current Advances and Challenges in Multi-OMICS Approach in Autism Spectrum Disorder for Biomarkers Discovery and Patient StratificationAreej G. Mesleh (18520065)Sara A. Abdulla (13902015)Omar El-Agnaf (2134222)Biomedical and clinical sciencesNeurosciencesautism spectrum disorderbiomarkeromicsprecision medicineproteomicstranscriptomicsepigeneticsmetabolomicspatient stratification<div><p>Autism spectrum disorder (ASD) is a multifactorial neurodevelopmental disorder characterized by impairments in two main areas: social/communication skills and repetitive behavioral patterns. The prevalence of ASD has increased in the past two decades, however, it is not known whether the evident rise in ASD prevalence is due to changes in diagnostic criteria or an actual increase in ASD cases. Due to the complexity and heterogeneity of ASD, symptoms vary in severity and may be accompanied by comorbidities such as epilepsy, attention deficit hyperactivity disorder (ADHD), and gastrointestinal (GI) disorders. Identifying biomarkers of ASD is not only crucial to understanding the biological characteristics of the disorder, but also as a detection tool for its early screening. Hence, this review gives an insight into the main areas of ASD biomarker research that show promising findings. Finally, it covers success stories that highlight the importance of precision medicine and the current challenges in ASD biomarker discovery studies.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Journal of Personalized Medicine<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/jpm11010041" target="_blank">https://dx.doi.org/10.3390/jpm11010041</a></p>2021-01-13T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/jpm11010041https://figshare.com/articles/journal_contribution/Paving_the_Way_toward_Personalized_Medicine_Current_Advances_and_Challenges_in_Multi-OMICS_Approach_in_Autism_Spectrum_Disorder_for_Biomarkers_Discovery_and_Patient_Stratification/25771995CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/257719952021-01-13T03:00:00Z |
| spellingShingle | Paving the Way toward Personalized Medicine: Current Advances and Challenges in Multi-OMICS Approach in Autism Spectrum Disorder for Biomarkers Discovery and Patient Stratification Areej G. Mesleh (18520065) Biomedical and clinical sciences Neurosciences autism spectrum disorder biomarker omics precision medicine proteomics transcriptomics epigenetics metabolomics patient stratification |
| status_str | publishedVersion |
| title | Paving the Way toward Personalized Medicine: Current Advances and Challenges in Multi-OMICS Approach in Autism Spectrum Disorder for Biomarkers Discovery and Patient Stratification |
| title_full | Paving the Way toward Personalized Medicine: Current Advances and Challenges in Multi-OMICS Approach in Autism Spectrum Disorder for Biomarkers Discovery and Patient Stratification |
| title_fullStr | Paving the Way toward Personalized Medicine: Current Advances and Challenges in Multi-OMICS Approach in Autism Spectrum Disorder for Biomarkers Discovery and Patient Stratification |
| title_full_unstemmed | Paving the Way toward Personalized Medicine: Current Advances and Challenges in Multi-OMICS Approach in Autism Spectrum Disorder for Biomarkers Discovery and Patient Stratification |
| title_short | Paving the Way toward Personalized Medicine: Current Advances and Challenges in Multi-OMICS Approach in Autism Spectrum Disorder for Biomarkers Discovery and Patient Stratification |
| title_sort | Paving the Way toward Personalized Medicine: Current Advances and Challenges in Multi-OMICS Approach in Autism Spectrum Disorder for Biomarkers Discovery and Patient Stratification |
| topic | Biomedical and clinical sciences Neurosciences autism spectrum disorder biomarker omics precision medicine proteomics transcriptomics epigenetics metabolomics patient stratification |